Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Positive Autoregulation

Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_551


Positive autoregulation (PAR) occurs when a transcription factor enhances its own rate of production. As effects of PAR, response times are slowed and variation is usually enhanced. In the case of a strong PAR the motif may lead to bimodal distribution of protein levels in cell populations (Alon 2006, 2007).


  1. Alon U (2006) Introduction to systems biology: design principles of biological circuits. CRC, Boca RatonGoogle Scholar
  2. Alon U (2007) Network motifs: theory and experimental approaches. Nat Rev Genet 8:450–461PubMedGoogle Scholar

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© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Zhou Pei-Yuan Center for Applied Mathematics, Tsinghua University of BeijingBeijingChina