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Inspired by gene ontology, edge ontology provides a hierarchical vocabulary of terms for describing interactions between biological molecules. Different types of relationships between pathway components can be represented by edge ontology. Lu et al. (2007) provide a prototype of an edge ontology that divides edge into four levels: direction, type, subtype, and specification. Edge ontology is quite a novel concept still far from being completed.
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Lu LJ, Sboner A, Huang YJ, Lu HX, Gianoulis TA, Yip KY, Kim PM, Montelione GT, Gerstein MB. Comparing classical pathways and modern networks: towards the development of an edge ontology. Trends Biochem Sci. 2007;32(7):320–331.
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Wang, J. (2013). Edge Ontology. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_493
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DOI: https://doi.org/10.1007/978-1-4419-9863-7_493
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4419-9862-0
Online ISBN: 978-1-4419-9863-7
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