Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Pathway Crosstalk

  • Yu-Qing QiuEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_470



Pathway crosstalk is the phenomenon of pathway interaction or cooperation. The signal-inducing conditions such as environmental stimulations can activate different pathways by inducing shared signal components of them. This mechanism explains cell’s multiple responses to the inducing signal, where one specific pathway accounts for one biological process. For example, several studies have demonstrated that TGFβ and Wnt pathways can cooperate to regulate differentiation and cell fate determination by controlling gene expression patterns (Attisano and Labbe 2004). Crosstalk between metabolism pathways is also observed. In plants, the metabolic crosstalk between cytosolic and plastidial pathways plays an important role in isoprenoid biosynthesis (Bick and Lange 2003).

Genetic screenings where synthetic lethality of two mutations often indicates interaction between two pathways where those two mutations...

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  1. Attisano L, Labbe E (2004) TGFβ and Wnt pathway cross-talk. Cancer Metastasis Rev 23:53–61PubMedGoogle Scholar
  2. Bick JA, Lange BM (2003) Metabolic cross talk between cytosolic and plastidial pathways of isoprenoid biosynthesis: unidirectional transport of intermediates across the chloroplast envelope membrane. Arch Biochem Biophys 415(2):146–154PubMedGoogle Scholar
  3. Li Y, Agarwal P, Rajagopalan D (2008) A global pathway crosstalk network. Bioinformatics 24(12):1442–1447PubMedGoogle Scholar

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© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Department of Chemical PathologyThe Chinese University of Hong KongHong KongChina