Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Pathway

Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_467

Definition

Pathway refers to a functional path in the biological networks. It is characterized by its connectivity, orientation, functionality, and dynamics. Thus, not all paths are pathways in biological networks.

In metabolic networks, it is often called metabolic pathways as a whole (Horton et al. 2005). In protein-protein interaction networks, it is often the same as the signaling pathways (Lewin 2003). In gene regulatory networks, it often means the mechanism under which expression quantitative trait loci regulate the expression of their target transcripts. In KEGG (Ogata et al. 1999), the pathway concept is also extended to cell communication, organismal systems, diseases, and drug responses.

Cross-References

References

  1. Horton R, Moran AL, Scrimgeour G, Perry M, Rawn D (2005) Principles of biochemistry, 4th edn. Pearson Education, Upper Saddle River, New JerseyGoogle Scholar
  2. Lewin B (2003) Genes VIII, 1st edn. Pearson Education, Upper Saddle River, New JerseyGoogle Scholar
  3. Ogata H, Goto S, Sato K, Fujibuchi W, Bono H, Kanehisa M (1999) KEGG: Kyoto encyclopedia of genes and genomes. Nucl Acids Res 27(1):29–34PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Key Laboratory of Systems Biology of Pathogens, Ministry of HealthInstitute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina