Network Motifs of Gene Regulatory Networks
In the gene regulatory network of Escherichia coli and yeast, network motifs refer to those regulatory interacting patterns that occur in original networks at numbers that are significantly higher than those in randomized networks (Milo et al. 2002; Shen-Orr et al. 2002; Alon 2007). These network motifs are responsible for diverse functions and behaviors of E. coli and yeast. They comprise feed forward loop (FFL), single-input module motif, SIM, and dense overlapping regulons (DOR).
Network Motif Structure
A network motif of a regulatory network is composed of nodes and regulations that connect the nodes. It defines the interacting patterns that are preferred by the gene regulatory network. Many genes in the regulatory network are organized by the preferred regulatory patterns. For example, a network motif may be\(\; A \to B \to C \)