Definition
Eukaryotic cell cycle is the sequence of cellular and molecular events ensuring the coordinated growth, DNA replication, and division necessary for a stable proliferation of the cell population. Cell cycle must be (and is) regulated in such a way that the individual cell as well as the population can react to not only changes in the environment such as changes of nutrient availability, temperature, pH value, osmolarity, but also presence of chemicals, hormones, or pheromones. This will be explained here for baker’s yeast (Saccharomyces cerevisiae) as model organism. Especially the presence or absence of nutrients and the respective availability of energy have strong impact on the cell cycle: Yeast cells growing on ethanol medium have a longer cell cycle period, but grow slower and divide at smaller sizes than cells grown on glucose medium.
The molecular backbone of cell cycle regulation consists mainly of three types of components: cyclins, cyclin-dependent kinases (CDK),...
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Klipp, E. (2013). Modeling Approaches of Cell Cycle Regulation by Signaling Pathways for External Stress. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_43
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DOI: https://doi.org/10.1007/978-1-4419-9863-7_43
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