Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Post-Transcriptional Gene Networks

  • Luiz O. F. Penalva
  • Dat T. Vo
  • Daniel R. Boutz
  • Andrew D. Smith
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_312



Post-transcriptional gene regulatory networks are defined by a specific gene subset sharing commonalities in biological functions, ontology, or pathway that are co-regulated by either a specific  RNA binding protein (RBP) or miRNA. MiRNAs and RBPs can regulate simultaneously the expression of hundreds of genes by recognizing specific sequence motifs located in  untranslated regions (UTRs) in mRNA and in  exons and  introns in pre-mRNAs.


RBPs and their Role in Post-Transcriptional Regulation

Eukaryotes must coordinate the expression of multiple genes to accomplish diverse biological functions that are necessary for processes that include cell division, growth, and differentiation, among others. A major part of this coordinated expression occurs at the post-transcriptional level and is mainly controlled by RBPs. Among processes controlled...

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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  • Luiz O. F. Penalva
    • 1
  • Dat T. Vo
    • 1
  • Daniel R. Boutz
    • 2
  • Andrew D. Smith
    • 3
  1. 1.Department of Cellular and Structural Biology, Greehey Children’s Cancer Research InstituteUniversity of Texas Health Science CenterSan AntonioUSA
  2. 2.Institute for Cellular and Molecular BiologyUniversity of TexasAustinUSA
  3. 3.Molecular and Computational Biology Section, Division of Biological SciencesUniversity of Southern CaliforniaLos AngelesUSA