Post-Transcriptional Gene Networks
Post-transcriptional gene regulatory networks are defined by a specific gene subset sharing commonalities in biological functions, ontology, or pathway that are co-regulated by either a specific RNA binding protein (RBP) or miRNA. MiRNAs and RBPs can regulate simultaneously the expression of hundreds of genes by recognizing specific sequence motifs located in untranslated regions (UTRs) in mRNA and in exons and introns in pre-mRNAs.
RBPs and their Role in Post-Transcriptional Regulation
Eukaryotes must coordinate the expression of multiple genes to accomplish diverse biological functions that are necessary for processes that include cell division, growth, and differentiation, among others. A major part of this coordinated expression occurs at the post-transcriptional level and is mainly controlled by RBPs. Among processes controlled...
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