Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Pharmacokinetic Modeling

Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_297


Pharmacokinetics is the discipline that describes and models in vivo the fate of drugs in a whole living organism, or at a lower level in a tissue, in a population of cells, or in a cell. In vitro in a dedicated medium designed to experimentally identify molecular mechanisms, but also in vivo in a cell, it describes this fate by a sequence of events that rely physiologically on molecular chemical reactions involving by their concentrations the drug, its targets, and the molecules that are involved in its activation, degradation, and possible active expulsion (efflux) through an external membrane, cellular or artificial, whereas classical pharmacokinetics may use only experimental curves to describe the fate of drugs, pharmacokinetic modeling is this part of pharmacokinetics that uses equations, ODEs (q.v.), or PDEs (q.v.) to represent the evolution of drug concentrations in the considered medium, for example, the whole body divided into compartments, or some intracellular or...

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© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Equipe-Projet BANGINRIA Paris-Rocquencourt BP 105Le Chesnay, ParisFrance