Reference Work Entry

Encyclopedia of Systems Biology

pp 593-594

Disease-oriented Causal Networks

  • Sanjeev KumarAffiliated withBioCOS Life Sciences Private Limited Email author 
  • , Shipra AgrawalAffiliated withBioCOS Life Sciences Pvt. Limited, Institute of Bioinformatics and Applied Biotechnology


DOCN represents the relationship across disease, candidate genes, regulatory genes and their functions to define the causal relationship through a gene or protein network. The connectivity across the network is established through directed graphs where the nodes or genes are variables, which are connected through edges. The graph indicates interaction between and across the genes (nodes) to ultimately describe the causal mechanism of a disease. In the DOCN, the graph shows how the change of the state of one variable affects the certainty of the state of another variable hence these causal networks are graphical representations of causal relationships between the variables of the graph. For example, obesity is one of the factors for developing insulin resistance, which in turn is the cause for type 2 diabetes.


Usage of the Disease-Oriented Causal Networks

Disease mechanisms can be explained using causal networks. These networks are used to ...

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