Skip to main content

Single Cell Experiments

  • Reference work entry
Encyclopedia of Systems Biology
  • 80 Accesses

Definition

The stem cell is an unspecialized cell that can self-renew and give rise to specialized cell lineages, such as a blood cell. Stem cells are found in all multicellular organisms. Stem cells can now be grown and can differentiate into specialized cell types with characteristics consistent with cells of various tissues such as blood, muscles, or nerves in in vitro cultures. Up-to-now, highly plastic adult stem cells are broadly used in clinical therapies. Highly purified and characterized stem cells from mice have opened up exceedingly rich fields of basic research with a variety of clinical potential. Many of the techniques used in the study of stem cell biology have become more standardized nowadays. In this entry, we provide information on up-to-date tools for studying stem cells. We wish the information in this entry will help accelerate studies in the stem cell field.

Single Stem Cell Studies

A stem cell is characterized by its ability to self-renew, high proliferative...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 899.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 549.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Broxmeyer HE, Smith FO (2009) Cord blood hematopoietic cell transplantation. In: Appelbaum FR, Forman SJ, Negrin RS, Blume KG (eds) Thomas’ hematopoietic cell transplantation, 4th edn. Wiley-Blackwell, West Sussex

    Google Scholar 

  • Burt RK, Loh Y, Pearce W et al (2008) Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases. J Am Med Assoc 299:925–936

    Article  CAS  Google Scholar 

  • Cairo MS, Wagner JE (1997) Placental and/or umbilical cord blood: an alternative source of hematopoietic stem cells for transplantation. Blood 90:4665–4678

    PubMed  CAS  Google Scholar 

  • McCulloch EA, Till JE (1960) The radiation sensitivity of normal mouse bone marrow cells, determined by quantitative marrow transplantation into irradiated mice. Radiat Res 13:115–125

    Article  PubMed  CAS  Google Scholar 

  • Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663–676

    Article  PubMed  CAS  Google Scholar 

  • Tyndall A, Fassas A, Passweg J et al (1999) Autologous haematopoietic stem cell transplants for autoimmune disease – feasibility and transplant-related mortality. Autoimmune disease and lymphoma working parties of the European group for blood and marrow transplantation, the European league against rheumatism and the international stem cell project for autoimmune disease. Bone Marrow Transplant 24:729–734

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Feng-Chun Yang .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media, LLC

About this entry

Cite this entry

Yang, FC. (2013). Single Cell Experiments. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_185

Download citation

Publish with us

Policies and ethics