Mammalian HDAC

Synonyms

Mammalian histone deacetylase

Definition

In mammals, HDAC1 and HDAC2, both of which are class I HDACs, form various multi-protein complexes, e.g., Sin3, NuRD, and CoREST (Yang and Seto 2008; Hayakawa and Nakayama 2011). The Sin3 complex contains HDAC1, HDAC2, RbAp46, RbAp48, SAP18, SAP30, MRG15, Pf1, EMSY, and RBP2 in addition to either form of Sin3, i.e., mSin3A or mSin3B. During embryonic development, mSin3A- and mSin3B-containing complexes implement distinct functions: mSin3A is required at the preimplantation stage, whereas mSin3B is required later in gestation. mSin3A/B, MRG15, and Pf1 are similar to yeast Sin3p, Eaf3p, and Rco1p, respectively. Therefore, the Sin3 complex is structurally homologous to yeast Rpd3S. However, it is still unclear whether the mSin3 complex exhibits an Rpd3S-like activity that prevents cryptic transcription from the coding regions of target genes.

The NuRD complex shares four subunits (i.e., HDAC1, HDAC2, RbAp46, and RbAp48) with the mSin3...