Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Pharmaceutical Toxicology, Application of Biosimulation

  • David CookEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_1487



Pharmaceutical Toxicology and the Assessment of Pharmaceutical Safety

Pharmaceutical toxicology is a discipline concerned with the assessment of the adverse toxicological effects associated with the chemical, pharmaceutical, and biological properties of agents produced to treat human disease (Mulder and Dencker 2006). Pharmaceutical toxicology is multidisciplinary and encompasses a range of scientific, clinical, and regulatory approaches aimed at the prediction, understanding, and management of the hazards and risks that may be associated with pharmaceutical agents in patients. These risks need to be balanced against the anticipated clinical benefit that the pharmaceutical agents may afford. The level of benefit/risk considered acceptable for an individual agent is not absolute and is heavily dependent on the therapeutic context. In general, treatments of acute life-threatening diseases (e.g., cancer,...

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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.AstraZenecaTranslational Patient Safety and Enabling ScienceMacclesfield, ChesterUK