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The input of a system is the set of experimental conditions stimulating or perturbing the biological process of interest (Kreutz and Timmer 2009). Typical perturbations or inputs are knockdowns or knockouts of compounds, overexpression, as well as stimulation of the system, e.g., by hormones or drugs. Because an input can be time varying, it can be modeled as continuous input function u(t). In more technical applications, also chemical or physical quantities like pH, temperature, or pressure are considered as inputs.
In mathematical terms, a model F(t, u, θ) describing the dynamic behavior of a biological system of interest depends on time t, on the input u, as well as on the model parameters θ.
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References
Kreutz C, Timmer J (2009) Systems biology: experimental design. FEBS J 276:923–942
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Kreutz, C., Timmer, J. (2013). Input. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_1467
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DOI: https://doi.org/10.1007/978-1-4419-9863-7_1467
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4419-9862-0
Online ISBN: 978-1-4419-9863-7
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