Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

PSISCORE (Quality Scoring of Protein Interactions)

Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_1464



PSISCORE is a decentralized, web-based system that facilitates qualitative assessment of molecular interaction data (Aranda et al. 2011). The user sends interaction data in a standardized PSI MI format ( Proteomics Data Formats;  Proteomics Standards Initiative;  PSISCORE (Quality Scoring of Protein Interactions)) via dedicated clients to multiple confidence scoring servers, which assess the data quality based on different biological aspects of molecular interactions. The resulting confidence scores are integrated with the interaction data and returned to the user. The PSISCORE registry maintains a list of available confidence scoring servers. Since PSISCORE is an open system, free software to develop new servers and clients is available on the project website together with further information (http://psiscore.googlecode.com).


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  1. Aranda B, Blankenburg H, Kerrien S, Brinkman FS, Ceol A, Chautard E, Dana JM, De Las RJ, Dumousseau M, Galeota E, Gaulton A, Goll J, Hancock RE, Isserlin R, Jimenez RC, Kerssemakers J, Khadake J, Lynn DJ, Michaut M, O'Kelly G, Ono K, Orchard S, Prieto C, Razick S, Rigina O, Salwinski L, Simonovic M, Velankar S, Winter A, Wu G, Bader GD, Cesareni G, Donaldson IM, Eisenberg D, Kleywegt GJ, Overington J, Ricard-Blum S, Tyers M, Albrecht M, Hermjakob H (2011) PSICQUIC and PSISCORE: accessing and scoring molecular interactions. Nat Methods 8:528–529PubMedGoogle Scholar

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© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Computational Biology and Applied AlgorithmicsMax Planck Institute for InformaticsSaarbrückenGermany