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Principal Component Analysis (PCA)

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Encyclopedia of Systems Biology

Synonyms

Eigen decomposition; Latent factor analysis; Singular value decomposition (SVD)

Definition

PCA is a statistical tool used to explore complex series of multivariate observations by which we can summarize a great amount of data through recognition of its most relevant information content. PCA behaves as a filtering-compression technique that captures the main trends in the data while revealing their underlying structure (Johnson and Wichner 1998; Brereton 2003; Wall et al. 2003).

Characteristics

Motivation Problem

When in a set of n “objects” (the experimental units) m attributes are measured, a cloud of points would appear when objects are represented in a space where each axis corresponds to one variable. PCA focuses on the “shape” of such cloud, trying to capture the cloud’s dominating directions(the eigenvectors). When these data are projected onto a lower-dimensional subspace, delimited by the eigenvectors of the cloud, a clearer visualization of the relationship between...

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References

  • Brereton R (2003) Data analysis for the laboratory to chemistry plant. Wiley, New York, pp 121–223 (Chap 4)

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  • Johnson RA, Wichner DW (1998) Applied multivariate statistical analysis, 4th edn. Prentice Hall, New Jersey, pp 458–512

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  • Varmuza K, Filzmoser P (2009) Introduction to multivariate statistical analysis in chemometrics. Taylor and Francis Group-CRC Press, Boca Raton, USA, pp 31–78

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  • Wall ME, Rechtsteiner A, Rocha LM (2003) Singular value decomposition and principal component analysis. In: Dubitzky W, Granzow M, Berrar DP (eds) A practical approach to microarray data analysis. Kluwer, Norwell, pp 91–109. LANL LA-UR-02-4001. http://public.lanl.gov/mewall/kluwer2002.html

  • Wold S (1987) Principal component analysis. Chemometrics and intelligent laboratory systems, 2(1):37–52

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Correspondence to Daniel V. Guebel .

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Guebel, D.V., Torres, N.V. (2013). Principal Component Analysis (PCA). In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_1276

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