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Systems Immunology, Novel Evaluation of Vaccine

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Synonyms

Systems vaccinology; Vaccine molecular signatures; Vaccinomics

Definition

Systems biology offers a new approach to vaccine design by understanding the molecular networks mobilized by vaccination. Systems vaccinology approaches investigate global correlates of successful vaccination, beyond antigen-specific immune responses, providing new methods for measuring early vaccine efficacy and generating hypotheses for understanding the mechanisms that underlie successful immunogenicity. Using functional genomics, vaccine-specific molecular signatures can be identified and used as predictors of efficient immune responses.

Characteristics

Vaccine

Vaccines are the most effective tools to prevent infectious diseases in humans or animals. A vaccine typically contains an agent resembling a disease-causing microorganism. The agent (antigens) stimulates the body’s immune system to recognize the agent as foreign, inducing specific immune responses and memory for long-term protection. Vaccines...

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  • DOI: 10.1007/978-1-4419-9863-7_107
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Correspondence to David Klatzmann .

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Bellier, B., Six, A., Thomas-Vaslin, V., Klatzmann, D. (2013). Systems Immunology, Novel Evaluation of Vaccine. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_107

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