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Encyclopedia of Systems Biology pp 2089–2092Cite as

Systems Immunology, Novel Evaluation of Vaccine

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Synonyms

Systems vaccinology; Vaccine molecular signatures; Vaccinomics

Definition

Systems biology offers a new approach to vaccine design by understanding the molecular networks mobilized by vaccination. Systems vaccinology approaches investigate global correlates of successful vaccination, beyond antigen-specific immune responses, providing new methods for measuring early vaccine efficacy and generating hypotheses for understanding the mechanisms that underlie successful immunogenicity. Using functional genomics, vaccine-specific molecular signatures can be identified and used as predictors of efficient immune responses.

Characteristics

Vaccine

Vaccines are the most effective tools to prevent infectious diseases in humans or animals. A vaccine typically contains an agent resembling a disease-causing microorganism. The agent (antigens) stimulates the body’s immune system to recognize the agent as foreign, inducing specific immune responses and memory for long-term protection. Vaccines...

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  • DOI: 10.1007/978-1-4419-9863-7_107
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Author information

Authors and Affiliations

  1. Immunology-Immunopathology-Immunotherapy, UPMC University Paris 06, UMR7211, CNRS, UMR7211, INSERM, U959, F-75013, Paris, France

    Bertrand Bellier, Dr. Adrien Six, Dr. Véronique Thomas-Vaslin & Dr. David Klatzmann

Authors
  1. Bertrand Bellier
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  2. Dr. Adrien Six
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  3. Dr. Véronique Thomas-Vaslin
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  4. Dr. David Klatzmann
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Corresponding author

Correspondence to David Klatzmann .

Editor information

Editors and Affiliations

  1. Biomedical Sciences Research Institute, University of Ulster, Coleraine, UK

    Werner Dubitzky

  2. Department of Computer Science, University of Rostock, Rostock, Germany

    Olaf Wolkenhauer

  3. Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea

    Kwang-Hyun Cho

  4. Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA

    Hiroki Yokota

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© 2013 Springer Science+Business Media, LLC

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Bellier, B., Six, A., Thomas-Vaslin, V., Klatzmann, D. (2013). Systems Immunology, Novel Evaluation of Vaccine. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_107

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