Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Systems Immunology, Novel Evaluation of Vaccine

Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_107



Systems biology offers a new approach to vaccine design by understanding the molecular networks mobilized by vaccination. Systems vaccinology approaches investigate global correlates of successful vaccination, beyond antigen-specific immune responses, providing new methods for measuring early vaccine efficacy and generating hypotheses for understanding the mechanisms that underlie successful immunogenicity. Using functional genomics, vaccine-specific molecular signatures can be identified and used as predictors of efficient immune responses.



Vaccines are the most effective tools to prevent infectious diseases in humans or animals. A vaccine typically contains an agent resembling a disease-causing microorganism. The agent (antigens) stimulates the body’s immune system to recognize the agent as foreign, inducing specific immune responses and memory for long-term protection. Vaccines...

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Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Immunology-Immunopathology-ImmunotherapyUPMC University Paris 06, UMR7211, CNRS, UMR7211, INSERM, U959ParisFrance