Systems Immunology, Novel Evaluation of Vaccine
Systems biology offers a new approach to vaccine design by understanding the molecular networks mobilized by vaccination. Systems vaccinology approaches investigate global correlates of successful vaccination, beyond antigen-specific immune responses, providing new methods for measuring early vaccine efficacy and generating hypotheses for understanding the mechanisms that underlie successful immunogenicity. Using functional genomics, vaccine-specific molecular signatures can be identified and used as predictors of efficient immune responses.
Vaccines are the most effective tools to prevent infectious diseases in humans or animals. A vaccine typically contains an agent resembling a disease-causing microorganism. The agent (antigens) stimulates the body’s immune system to recognize the agent as foreign, inducing specific immune responses and memory for long-term protection....