Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota


Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_1061


Very large, barrel-shaped, multimeric proteolytic complexes, present in both the nucleus and the cytoplasm, involved in the degradation of multiple ubiquitin-conjugated proteins, that play important roles in cell cycle regulation, cellular differentiation, and other processes that require protein degradation.


Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Instituto de Biología Molecular y Celular del Cáncer, CSIC/Universidad de SalamancaSalamancaSpain