Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Prereplicative Complex

Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_1060

Synonyms

 Pre-RC

Definition

Complex of proteins that sequentially assembles to DNA at the origin of replication during late mitosis and G1, when CDK activity is low, and that is required, once activated, to initiate DNA replication at S phase. In Saccharomyces cerevisiae it is composed of ORC proteins, Cdc6, MCM helicases, and Cdt1.

Cross-References

Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.Instituto de Biología Molecular y Celular del Cáncer, CSIC/Universidad de SalamancaSalamancaSpain