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Systems Immunology, Adaptive Immune Response to HIV Infection

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Synonyms

Host adaptive immune response to HIV infection; Systems network in HIV

Definition

Systems immunology, under the umbrella of system biology, provides integrated approaches at different level of complexity to define the underlying mechanisms of adaptive immune responses to HIV infection. With the advent of high-throughput data acquisition platforms coupled with advances in computational biology, systems immunology approaches to HIV infection investigate molecular signatures of adaptive immunity in response to HIV infection, evaluate and establish pathways and/or networks linking biomolecules to perturbations related to HIV infection, and generate testable hypotheses. Thus, it offers better platforms to define networks of molecular modules that are unique to HIV infection, activation, replication, and pathogenesis. Elucidation of these molecular modules should eventually lead to defining better treatment options to HIV infection.

Characteristics

Adaptive Immune Response

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Systems Immunology, Adaptive Immune Response to HIV Infection, Fig. 1
Systems Immunology, Adaptive Immune Response to HIV Infection, Fig. 2
Systems Immunology, Adaptive Immune Response to HIV Infection, Fig. 3
Systems Immunology, Adaptive Immune Response to HIV Infection, Fig. 4

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Acknowledgments

This work is supported in part by NCRR Grant UL1-RR-024989, NIDA Grant P20-DA-026133, CFAR Grant P30-AI-036219, and NIDCR Grant P01-DE-019759.

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Correspondence to Mark R. Chance .

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Yohannes, E., Chance, M.R. (2013). Systems Immunology, Adaptive Immune Response to HIV Infection. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_104

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