Protein–Protein Interaction Databases
Protein–protein interaction (PPI) databases collect and store data on known interactions between proteins. The data are often gathered either through direct user submissions or by curation of publications in the literature that describe PPIs. In addition to the identity of the interactors themselves, most databases provide additional information, such as literature citations (PubMed; see MEDLINE and PubMed) and details on the supporting evidence (e.g., experimental methods used, roles of the interactors in the experiments, cell lines, etc.). PPI databases are invaluable for the reconstruction of protein–protein interaction networks ( Protein-Protein Interaction Networks).
Literature-Curated PPI Databases
Large-scale curation of PPI data from the literature was pioneered by several organism-centric genomic and proteomic databases. Eventually however, their curation capacities were exceeded by the...
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