Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Protein Complex Resources

Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_1045

Definition

A protein complex comprises of two or more proteins, whose individual properties contribute to characteristics of the complex, such as specificity, localization, and enzymatic function.

Protein complexes carry out most cellular processes. Motility, signal transduction, synthesis and degradation of biomolecules, and passage through the cell cycle are all orchestrated by protein complexes with precise organization and regulation (Alberts 1998).

Resources on protein complexes take their experimental data from high-throughput affinity purification experiments coupled with mass spectrometry (reviewed by Gingras et al. 2007). These experiments have enabled the isolation and identification of the complexosome, which represents all protein complexes in an organism.

Characteristics

Resources

Because the formation of protein complexes relies on protein-protein interactions, many such databases (Protein-Protein Interaction Databases) carry information on protein complexes.

Efforts to...

This is a preview of subscription content, log in to check access

References

  1. Alberts B (1998) The cell as a collection of protein machines: preparing the next generation of molecular biologists. Cell 92:291–294PubMedGoogle Scholar
  2. Arifuzzaman M (2006) Large-scale identification of protein-protein interaction of Escherichia coli K-12. Genome Res 16(5):686–691PubMedGoogle Scholar
  3. Butland G, Peregrín-Alvarez JM, Li J, Yang W, Yang X, Canadien V, Starostine A et al (2005) Interaction network containing conserved and essential protein complexes in Escherichia coli. Nature 433(7025):531–537PubMedGoogle Scholar
  4. Gavin AC et al (2006) Proteome survey reveals modularity of the yeast cell machinery. Nature 440:631–636PubMedGoogle Scholar
  5. Gingras A et al (2007) Analysis of protein complexes using mass spectrometry. Nat Rev Mol Cell Biol 8:645–653PubMedGoogle Scholar
  6. Krogan NJ et al (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature 440:637–643PubMedGoogle Scholar
  7. Levy ED, Pereira-Leal JB, Chothia C, Teichmann SA (2006) 3D complex: A structural classification of protein complexes. Plos Computational Biology 2(11):1395–1406Google Scholar
  8. Ruepp A et al (2009) CORUM: the comprehensive resource of mammalian protein complexes – 2009. Nucleic Acids Res 38:D497–D501PubMedGoogle Scholar
  9. Su C, Peregrin-Alvarez JM, Butland G, Phanse S, Fong V, Emili A, Parkinson J (2008) Bacteriome.org – an integrated protein interaction database for E. coli. Nucl Acids Res, 36 (Database issue), D632–d636. doi:10.1093/nar/gkm807Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.BioSyntha TechnologyWelwyn Garden CityUK