Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Protein Complex Resources

  • Annette A. Alcasabas
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_1045


A protein complex comprises of two or more proteins, whose individual properties contribute to characteristics of the complex, such as specificity, localization, and enzymatic function.

Protein complexes carry out most cellular processes. Motility, signal transduction, synthesis and degradation of biomolecules, and passage through the cell cycle are all orchestrated by protein complexes with precise organization and regulation (Alberts 1998).

Resources on protein complexes take their experimental data from high-throughput affinity purification experiments coupled with mass spectrometry (reviewed by Gingras et al. 2007). These experiments have enabled the isolation and identification of the complexosome, which represents all protein complexes in an organism.



Because the formation of protein complexes relies on protein-protein interactions, many such databases (Protein-Protein Interaction Databases) carry information on protein complexes.

Efforts to...

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© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.BioSyntha TechnologyWelwyn Garden CityUK