Protein Complex Resources
A protein complex comprises of two or more proteins, whose individual properties contribute to characteristics of the complex, such as specificity, localization, and enzymatic function.
Protein complexes carry out most cellular processes. Motility, signal transduction, synthesis and degradation of biomolecules, and passage through the cell cycle are all orchestrated by protein complexes with precise organization and regulation (Alberts 1998).
Resources on protein complexes take their experimental data from high-throughput affinity purification experiments coupled with mass spectrometry (reviewed by Gingras et al. 2007). These experiments have enabled the isolation and identification of the complexosome, which represents all protein complexes in an organism.
Because the formation of protein complexes relies on protein-protein interactions, many such databases (Protein-Protein Interaction Databases) carry information on protein complexes.
- Levy ED, Pereira-Leal JB, Chothia C, Teichmann SA (2006) 3D complex: A structural classification of protein complexes. Plos Computational Biology 2(11):1395–1406Google Scholar
- Su C, Peregrin-Alvarez JM, Butland G, Phanse S, Fong V, Emili A, Parkinson J (2008) Bacteriome.org – an integrated protein interaction database for E. coli. Nucl Acids Res, 36 (Database issue), D632–d636. doi:10.1093/nar/gkm807Google Scholar