Encyclopedia of Systems Biology

2013 Edition
| Editors: Werner Dubitzky, Olaf Wolkenhauer, Kwang-Hyun Cho, Hiroki Yokota

Protein Domain and Function Prediction Resources

Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-9863-7_1044

Definition

A domain is part of a protein sequence, typically between 10 and 20 amino acid residues, that performs a specific function, for example, catalytic or for protein binding. Domain prediction resources are online databases that use specific algorithms based on sequence alignment to predict domains within a protein.

A protein family is comprised of a number of related proteins that contain one or more conserved domains. Some domain prediction resources also give information on protein families.

Characteristics

Large-scale sequencing and high-throughput experimental screens have led to the discovery of many new and unannotated proteins. Their function can be deduced from sequence analysis, in particular from the identification of homologs and known motifs.

Traditionally, homologs and related proteins can be found by BLAST searches using the complete protein sequence. If a high degree of homology is shared with a known protein or protein family, then their functions are likely to...

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References

  1. Hunter S et al (2009) InterPro: the integrative protein structure database. Nucleic Acids Res 37:D211–D215. doi:10.1093/nar/gkn785PubMedGoogle Scholar
  2. Mulder NJ, Apweiler R (2002) Tools and resources for identifying protein families, domains and motifs. Genome Biol 3(1):REVIEWS2001. Epub 2001 Dec 19Google Scholar
  3. Pavlopoulou A, Michalopoulos I (2011) State-of-the-art bioinformatics protein structure and prediction tools. Int J Mol Med. doi:10.3892/ijmm.2011.705Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2013

Authors and Affiliations

  1. 1.BioSyntha TechnologyWelwyn Garden CityUK