Protein Domain and Function Prediction Resources

Definition

A domain is part of a protein sequence, typically between 10 and 20 amino acid residues, that performs a specific function, for example, catalytic or for protein binding. Domain prediction resources are online databases that use specific algorithms based on sequence alignment to predict domains within a protein.

A protein family is comprised of a number of related proteins that contain one or more conserved domains. Some domain prediction resources also give information on protein families.

Characteristics

Large-scale sequencing and high-throughput experimental screens have led to the discovery of many new and unannotated proteins. Their function can be deduced from sequence analysis, in particular from the identification of homologs and known motifs.

Traditionally, homologs and related proteins can be found by BLAST searches using the complete protein sequence. If a high degree of homology is shared with a known protein or protein family, then their functions are likely to...