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Encyclopedia of Systems Biology pp 1667–1670Cite as

Pattern Recognition Receptors

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Synonyms

Pathogen recognition receptor; Primitive pattern recognition receptor

Definition

Pattern recognition receptors (PRR) are proteins that scan the host tissues for nonself-entities such as invading microbes or altered/damaged host-tissue. PRRs recognize molecular patterns present on the surface of microbes or damaged/altered tissue. The recognition induces a series of protective immune processes.

Characteristics

Pattern Recognition Receptors

Pattern recognition receptor (PRR) is a superfamily of proteins that scans the host tissues for nonself-entities such as microbes or damaged tissue. The distinction between self and nonself is based on specific molecular patterns present on the surface or secreted by the foreign entities. In case of microbial infection, these molecular patterns are lipopolysaccharides (LPS), peptidoglycans, etc. Collectively, the microbial molecular patterns are referred to as microbe-associated molecular patterns or MAMPs. In cases of damaged host tissue,...

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References

  • Burmester G, Pezzutto A (2003) Color Atlas of Immunology. Georg Thieme Verlag, Stuttgart, Germany

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  • Egesten A, Schmidt A, Herwald H (2008) Trends in innate immunity. Karger, New York

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  • Surhone LM, Tennoe MT, Henssonow SF (2010) Pattern Recognition Receptor. Betascript Publishing, Mauritius

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  • Takeuchi O, Akira S (2010) Pattern recognition receptors and inflammation. Cell 140:805–820

    PubMed  CAS  Google Scholar 

  • Uday K (2009) Target pattern recognition in innate immunity, vol 653, Advances in experimental medicine and biology. Springer, New York

    Google Scholar 

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Author information

Authors and Affiliations

  1. Computational Biology Service Unit, Cornell University, Ithaca, NY, USA

    Dr. Harpreet Singh

  2. Biomedical Informatics Centre, Indian Council of Medical Research, Ansari Nagar, 110029, New Delhi, India

    Dr. Harpreet Singh

Authors
  1. Dr. Harpreet Singh
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Corresponding author

Correspondence to Harpreet Singh .

Editor information

Editors and Affiliations

  1. Biomedical Sciences Research Institute, University of Ulster, Coleraine, UK

    Werner Dubitzky

  2. Department of Computer Science, University of Rostock, Rostock, Germany

    Olaf Wolkenhauer

  3. Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea

    Kwang-Hyun Cho

  4. Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, USA

    Hiroki Yokota

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© 2013 Springer Science+Business Media, LLC

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Singh, H. (2013). Pattern Recognition Receptors. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_103

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