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Proteomics Workflow

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Encyclopedia of Systems Biology

Synonyms

Pipeline; Protocol

Definition

A workflow (Yu and Buyya 2005) is an ordered sequence of steps applied to a set of inputs (parameters and data) and producing some outputs. The steps can be part of a single application or may use several separate applications.

Workflows are often represented by graphs where nodes represent the steps, and edges the connectors between them, see Fig. 1. Most workflow management systems only allow the definition of a workflow as a directed acyclic graph. However, some can also handle loops or conditional execution to support iteration or event-driven decision points.

Proteomics Workflow, Fig. 1
figure 1647 figure 1647

A simple linear workflow which takes as inputs a database BLAST DB to search against, a query file, and control parameters. It consists of two steps, a BLAST (Altschul et al. 1990) search which finds database sequences similar to the query, and a multiple alignment where the hits from BLAST are aligned. The output of this workflow is an alignment

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References

  • Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215(3):403–10

    PubMed  CAS  Google Scholar 

  • Yu J, Buyya R (2005) A taxonomy of scientific workflow systems for grid computing. SIGMOD Rec 34(3):44–49

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Correspondence to Ela Pustulka-Hunt .

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Malmström, L., Quandt, A., Pustulka-Hunt, E. (2013). Proteomics Workflow. In: Dubitzky, W., Wolkenhauer, O., Cho, KH., Yokota, H. (eds) Encyclopedia of Systems Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-9863-7_1006

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