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Agenesis of Corpus Callosum

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Encyclopedia of Autism Spectrum Disorders

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Synonyms

Acallosal syndrome; Callosotomy (surgical severing); Complete agenesis; Dysgenesis (malformation); Hypogenesis (partial formation); Hypoplasia (underdevelopment); Partial agenesis

Short Description or Definition

The corpus callosum (CC) is the largest white matter fiber tract (also known as commissure) connecting the two hemispheres of the brain. Agenesis of the corpus callosum (AgCC) is present at birth and encompasses structural defects of the development of the corpus callosum that range from partial to complete loss of these connective fiber tracts. Primary AgCC is a complete loss of the CC without other accompanying brain changes. A rare individual diagnosed with autism or ASD is found to have AgCC.

Categorization

The CC is divided into seven subregions (see definition of the corpus callosum).

AgCC is divided into partial (Fig. 1) and complete (Fig. 2) based on whether one or more subregions are missing (Fig. 1) or whether the entire corpus callosum is absent (Fig. 2)....

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References and Readings

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Author information

Authors and Affiliations

  1. Research Center for Autism, The Cleveland Clinic, 2801 Martin Luther King Jr. Drive (CRS10), Cleveland, OH, 44195, USA

    Dr. Thomas Frazier (Director of Research)

  2. Department of Psychiatry and Behavioral Sciences, Stanford University, 401 Quarry Rd MC 5722, Stanford, CA, 94305, USA

    Prof. Antonio Hardan

Authors
  1. Dr. Thomas Frazier
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  2. Prof. Antonio Hardan
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Corresponding author

Correspondence to Antonio Hardan .

Editor information

Editors and Affiliations

  1. Irving B. Harris Professor of Child Psychiatry, Pediatrics and Psychology Yale University School of Medicine, Chief, Child Psychiatry Children's Hospital at Yale-New Haven Child Study Center, New Haven, CT, USA

    Fred R. Volkmar (Director, Child Study Center) (Director, Child Study Center)

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Frazier, T., Hardan, A. (2013). Agenesis of Corpus Callosum. In: Volkmar, F.R. (eds) Encyclopedia of Autism Spectrum Disorders. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1698-3_657

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  • DOI: https://doi.org/10.1007/978-1-4419-1698-3_657

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-1697-6

  • Online ISBN: 978-1-4419-1698-3

  • eBook Packages: Behavioral Science

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