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Depakene

  • Reference work entry
Encyclopedia of Autism Spectrum Disorders

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Synonyms

Divalproex; Valproic acid

Indications

Valproic Acid: Valproic acid is a simple carbonic acid. It is available in several preparations including divalproex and valproic acid. It appears to exert its beneficial effects by interfering with the repetitive firing of neurons. This appears to be especially relevant for its treatment of seizures. Valproic acid is approved for the treatment of seizures, migraine, and for the treatment of bipolar disorder.

Clinical Use (Including Side Effects)

It has been studied in children and adults with bipolar illness and appears to be an effective treatment. Valproic acid is often well tolerated, but it can have a range of adverse effects. Sedation and gastrointestinal disturbance with vomiting are common particularly at the start of treatment. Other more significant adverse effects include thrombocytopenia, pancreatitis, and rarely hepatotoxicity. These more severe adverse effects require monitoring of drug level in the blood, platelet counts,...

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References and Readings

  • Kowatch, R. A., Strawn, J. R., & Danielyan, A. (2011). Mood stabilizers: Lithium, anticonvulsants and others. In A. Martin, L. Scahill, & C. Kratochvil (Eds.), Pediatric psychopharmacology: Principles and practice (pp. 297–311). New York: Oxford University Press.

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Author information

Authors and Affiliations

  1. Nursing & Child Psychiatry, Yale University School of Nursing, Yale Child Study Center, 40 Temple Street; Suite 7D, Rm 738, P. O. Box 207900, New Haven, CT, 06520, USA

    Dr. Lawrence David Scahill (Professor of Nursing & Child Psychiatry)

Authors
  1. Dr. Lawrence David Scahill
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Corresponding author

Correspondence to Lawrence David Scahill .

Editor information

Editors and Affiliations

  1. Irving B. Harris Professor of Child Psychiatry, Pediatrics and Psychology Yale University School of Medicine, Chief, Child Psychiatry Children's Hospital at Yale-New Haven Child Study Center, New Haven, CT, USA

    Fred R. Volkmar (Director, Child Study Center) (Director, Child Study Center)

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© 2013 Springer Science+Business Media New York

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Scahill, L.D. (2013). Depakene. In: Volkmar, F.R. (eds) Encyclopedia of Autism Spectrum Disorders. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1698-3_1232

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  • DOI: https://doi.org/10.1007/978-1-4419-1698-3_1232

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-1697-6

  • Online ISBN: 978-1-4419-1698-3

  • eBook Packages: Behavioral Science

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