Definition
Pathophysiology (consisting of the Greek origin words “pathos” = suffering; “physis” = nature, origin; and “logos” = “the study of”) refers to the study of abnormal changes in body functions that are the causes, consequences, or concomitants of disease processes. Studies of pathophysiology are concerned with the investigation of biological processes that are directly related to disease processes of physical, mental, or psychophysiological conditions and disorders (e.g., alterations in the endocrine system, in certain neurotransmitters, or inflammatory parameters related to the activity of the immune system). Thus, pathophysiological research aims at identifying biological markers and mechanisms for predicting and explaining disease processes in terms of etiology and pathogenesis. Pathophysiology is formally considered as a subdiscipline within physiology.
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The fundamental aim of the domain of pathophysiology is to unravel the altered biological (i.e., physical and...
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References and Readings
Cornier, M.-A., Dabelea, D., Hernandez, T. L., Lindstrom, R. C., Steig, A. J., Stob, N. R., et al. (2008). The metabolic syndrome. Endocrine Reviews, 29, 777–822.
Ehlert, U., Gaab, J., & Heinrichs, M. (2001). Psychoneuroendocrinological contributions to the etiology of depression, post-traumatic stress disorder, and stress related bodily disorders: The role of the hypothalamus-pituitary-adrenal axis. Biological Psychology, 57, 141–152.
Heim, C., Ehlert, U., & Hellhammer, D. H. (2000). The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders. Psychoneuroendocrinology, 25, 1–35.
Heim, C., Nater, U., Maloney, E., Boneva, R., Jones, J. F., & Reeves, W. C. (2009). Childhood trauma and risk for chronic fatigue syndrome. Archives of General Psychiatry, 66, 72–80.
Latremoliere, A., & Woolf, C. J. (2009). Central sensitization: A generator of pain hypersensitivity by central neural plasticity. The Journal of Pain, 10, 895–926.
Lautenbacher, S., & Fillingim, R. B. (2004). Pathophysiology of pain perception. New York, NY: Kluwer Academic/Plenum.
Müller, M., & Holsboer, F. (2004). Hormones, stress and depression. In C. Kordon, R.-C. Gaillard, & Y. Christen (Eds.), Hormones and the brain. Berlin, NY: Springer.
Steptoe, A. (2010). Handbook of behavioral medicine – methods and application. New York: Springer.
Woolf, C. J. (2011). Central sensitization: Implications for the diagnosis and treatment of pain. Pain, 152, 2–15.
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Witthöft, M. (2013). Pathophysiology. In: Gellman, M.D., Turner, J.R. (eds) Encyclopedia of Behavioral Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1005-9_43
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DOI: https://doi.org/10.1007/978-1-4419-1005-9_43
Publisher Name: Springer, New York, NY
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