Encyclopedia of Behavioral Medicine

2013 Edition
| Editors: Marc D. Gellman, J. Rick Turner

Inflammatory Bowel Disease

Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-1005-9_409

Synonyms

Definition

Inflammatory bowel disease (IBD) is a specific group of chronic inflammatory conditions of the intestine. IBD consists of the two major diseases: ulcerative colitis (UC) and Crohn’s disease (CD). UC causes inflammation in the rectum, colon, and infrequently the terminal ileum. CD can involve any part of the gastrointestinal tract from the mouth to the anus and particularly affects the ileum and/or the colon. IBD most commonly begins during adolescence and early adulthood.

Description

Causes

The cause of IBD is not clearly known, but these diseases are thought to be due to an autoimmune process that has been triggered by unknown factors or agents, such as genetic predisposition, infection of microorganisms, and/or environmental factors. As a result of the ulcers and inflammatory reaction of the mucosal layer of the small intestine or the colon, the intestinal wall is damaged leading to bloody diarrhea and abdominal pain. In recent studies, psychosocial...

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References and Readings

  1. Bernstein, C. N., Blanchard, J. F., Kliewer, E., & Wajda, A. (2001). Cancer risk in patients with inflammatory bowel disease: A population-based study. Cancer, 91, 854–862.PubMedCrossRefGoogle Scholar
  2. Hanauer, S. B., Feagan, B. G., Lichtenstein, G. R., Mayer, L. F., Schreiber, S., Colombel, J. F., et al. (2002). Maintenance infliximab for Crohn’s disease: The ACCENT I randomised trial. Lancet, 359, 1541–1549.PubMedCrossRefGoogle Scholar
  3. Podolsky, D. K. (2002). Inflammatory bowel disease. New England Journal of Medicine, 347, 417–429.PubMedCrossRefGoogle Scholar
  4. Winawer, S., Fletcher, R., Rex, D., Bond, J., Burt, R., Ferrucci, J., et al. (2003). Gastrointestinal consortium panel. Colorectal cancer screening and surveillance: Clinical guidelines and rationale – Update based on new evidence. Gastroenterology, 124, 544–560.PubMedCrossRefGoogle Scholar
  5. Xavier, R. J., & Podolsky, D. K. (2007). Unravelling the pathogenesis of inflammatory bowel disease. Nature, 448, 427–434.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, New York 2013

Authors and Affiliations

  1. 1.Department of Behavioral Medicine, School of MedicineTohoku University GraduateAoba-ku, SendaiJapan