Definition
Interleukins (IL) are chemical messenger molecules of the immune system, and therefore fall into the category of cytokines. The term “interleukin” denotes their primarily ascribed function, i.e., the communication between (inter) white blood cells (leukocytes). IL-1, IL-6, and IL-18 are pro-inflammatory cytokines due to their predominant function to stimulate inflammatory processes in target cells.
Interleukin-1 is one of the first discovered cytokines, and consists of a family of three different molecules: IL-1alpha and IL-1beta exert their actions through binding to different members of the IL-1 receptor family, while the third molecule IL-1 receptor antagonist (IL-1ra) blocks these effects. The IL-1 family of cytokines was first cloned in 1984 (for a summary, see...
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References and Readings
Arend, W. P., Palmer, G., & Gabay, C. (2008). IL-1, IL-18, and IL-33 families of cytokines. Immunological Reviews, 223, 20–38.
Bruunsgaard, H., Ladelund, S., Pedersen, A. N., Schroll, M., Jorgensen, T., & Pedersen, B. K. (2003). Predicting death from tumour necrosis factor-alpha and interleukin-6 in 80-year-old people. Clinical and Experimental Immunology, 132(1), 24–31.
Brydon, L., Edwards, S., Jia, H., Mohamed-Ali, V., Zachary, I., Martin, J. F., et al. (2005). Psychological stress activates interleukin-1beta gene expression in human mononuclear cells. Brain, Behavior, and Immunity, 19(6), 540–546.
Dinarello, C. A. (1994). The interleukin-1 family: 10 years of discovery. The FASEB Journal, 8(15), 1314–1325.
Heinrich, P. C., Behrmann, I., Muller-Newen, G., Schaper, F., & Graeve, L. (1998). Interleukin-6-type cytokine signalling through the Gp130/Jak/Stat pathway. Biochemical Journal, 334(Pt 2), 297–314.
Hoch, M., Eberle, A. N., Peterli, R., Peters, T., Seboek, D., Keller, U., et al. (2008). LPS induces interleukin-6 and interleukin-8 but not tumor necrosis factor-alpha in human adipocytes. Cytokine, 41(1), 29–37.
Kishimoto, T. (2010). IL-6: From its discovery to clinical applications. International Immunology, 22(5), 347–352.
Kobayashi, S., Nagino, M., Komatsu, S., Naruse, K., Nimura, Y., Nakanishi, M., et al. (2003). Stretch-induced IL-6 secretion from endothelial cells requires NF-kappaB activation. Biochemical and Biophysical Research Communications, 308(2), 306–312.
Okamura, H., Tsutsi, H., Komatsu, T., Yutsudo, M., Hakura, A., Tanimoto, T., et al. (1995). Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature, 378(6552), 88–91.
Papanicolaou, D. A., & Vgontzas, A. N. (2000). Interleukin-6: The endocrine cytokine. The Journal of Clinical Endocrinology and Metabolism, 85(3), 1331–1333.
Poupart, P., Vandenabeele, P., Cayphas, S., Van Snick, J., Haegeman, G., Kruys, V., et al. (1987). B cell growth modulating and differentiating activity of recombinant human 26-kd protein (BSF-2, HuIFN-beta 2, HPGF). The EMBO Journal, 6(5), 1219–1224.
Rohleder, N., Marin, T. J., Ma, R., & Miller, G. E. (2009). Biologic cost of caring for a cancer patient: Dysregulation of pro- and anti-inflammatory signaling pathways. Journal of Clinical Oncology, 27(18), 2909–2915.
Rohleder, N., Wolf, J. M., Herpfer, I., Fiebich, B. L., Kirschbaum, C., & Lieb, K. (2006). No response of plasma substance P, but delayed increase of interleukin-1 receptor antagonist to acute psychosocial stress. Life Sciences, 78(26), 3082–3089.
Rohleder, N., Wolf, J. M., & Wolf, O. T. (2010). Glucocorticoid sensitivity of cognitive and inflammatory processes in depression and posttraumatic stress disorder. Neuroscience and Biobehavioral Reviews, 35(1), 104–114.
Steptoe, A., Hamer, M., & Chida, Y. (2007). The effects of acute psychological stress on circulating inflammatory factors in humans: A review and meta-analysis. Brain, Behavior, and Immunity, 21(7), 901–912.
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Rohleder, N. (2013). Interleukins, -1 (IL-1), -6 (IL-6), -18 (IL-18). In: Gellman, M.D., Turner, J.R. (eds) Encyclopedia of Behavioral Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1005-9_26
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