Synonyms
Definition
Biobehavioral mechanisms within behavioral medicine refer to the interaction of biological, psychosocial, behavioral, and environmental factors that contribute to health-related outcomes and disease status. Biological processes are believed to mediate the influence of psychosocial, behavioral, and environmental factors on health and disease outcomes.
Description
Research concerned with biobehavioral mechanisms of health and disease has primarily focused on the impact of psychosocial, behavioral, and environmental factors on biological processes of the immune and endocrine systems. These factors can impact biological responses individually and/or synergistically and may include both acute and chronic effects. Psychological distress in response to stressors (i.e., negative life events, both acute and chronic) has been related to alterations in immune and endocrine functioning and much of this work has focused on the effects of stress on immunocompetence and...
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References and Readings
Ackerman, K. D., Martino, M., Heyman, R., Moyna, N. M., & Rabin, B. S. (1996). Immunologic response to acute psychological stress in MS patients and controls. Journal of Neuroimmunology, 68, 85–94.
Ackerman, K. D., Martino, M., Heyman, R., Moyna, N. M., & Rabin, B. S. (1998). Stressor-induced alteration of cytokine production in multiple sclerosis patients and controls. Psychosomatic Medicine, 60, 484–491.
Ader, R., Cohen, N., & Felten, D. (1995). Psychoneuroimmunology: Interactions between the nervous system and the immune system. Lancet, 345, 99–103.
Ader, R., Felten, D. L., & Cohen, N. (2001). Psychoneuroimmunology (3rd ed.). San Diego, CA: Academic Press.
Andersen, B. L., Farrar, W. B., Golden-Kreutz, D., Kutz, L. A., MacCallum, R., Courtney, M. E., et al. (1998). Stress and immune responses after surgical treatment for regional breast cancer. Journal of the National Cancer Institute, 90, 30–36.
Andersen, B. L., Kiecolt-Glaser, J. K., & Glaser, R. (1994). A biobehavioral model of cancer stress and disease course. American Psychologist, 49(5), 389–404.
Antoni, M. H., August, S., LaPerriere, A., Baggett, H. L., Klimas, N., Ironson, G., et al. (1990). Psychological and neuroendocrine measures related to functional immune changes in anticipation of HIV-1 serostatus notification. Psychosomatic Medicine, 52, 496–510.
Aragona, M., Muscatello, M. R. A., Losi, E., Panetta, S., la Torre, F., Pastura, G., et al. (1996). Lymphocyte number and stress parameter modifications in untreated breast cancer patients with depressive mood and previous life stress. Journal of Experimental Therapeutics and Oncology, 1, 354–360.
Benjamini, E., Coico, R., & Sunshine, G. (2000). Immunology: A short course (4th ed.). New York: Wiley-Liss.
Biondi, M. (2001). Effects of stress on immune functions: An overview. In R. Ader, D. L. Felten, & N. Cohen (Eds.), Psychoneuroimmunology (3rd ed., pp. 189–226). San Diego, CA: Academic Press.
Black, P. H. (2003). The inflammatory response is an integral part of the stress response: Implications for atherosclerosis, insulin resistance, type II diabetes and metabolic syndrome X. Brain, Behavior, and Immunity, 17, 350–364.
Cannon, W. B. (1939). The wisdom of the body. New York: Norton.
Cohen, S., Tyrrell, D. A. J., & Smith, A. P. (1991). Psychological stress and susceptibility to the common cold. New England Journal of Medicine, 325(9), 606–612.
Cruess, D. G., Antoni, M. H., McGregor, B. A., Kilbourn, K. M., Boyers, A. E., Alferi, S. M., et al. (2000). Cognitive-behavioral stress management reduces serum cortisol by enhancing benefit finding among women being treated for early stage breast cancer. Psychosomatic Medicine, 62, 304–308.
Cruess, S., Antoni, M., Kilbourn, K., Ironson, G., Klimas, N., Fletcher, M. A., et al. (2007). Optimism, distress, and immunologic status in HIV-infected gay men following Hurricane Andrew. International Journal of Behavioral Medicine, 7, 160–182.
Glaser, R., Kiecold-Glaser, J. K., Bonneau, R. H., Malarkey, W., Kennedy, S., & Hughes, J. (1992). Stress-induced modulation of the immune response to recombinant hepatitis B vaccine. Psychosomatic Medicine, 54, 22–29.
Glaser, R., Sheridan, J., Malarkey, W. B., MacCallum, R. C., & Kiecolt-Glaser, J. K. (2000). Chronic stress modulates the immune response to a pneumococcal pneumonia vaccine. Psychosomatic Medicine, 62, 804–807.
Glaser, R., MacCallum, R. C., Laskowski, B. F., Malarkey, W. B., Sheridan, J. F., & Kiecolt-Glaser, J. K. (2001). Evidence for a shift in the Th-1 to Th-2 cytokine response associated with chronic stress and aging. Journal of Gerontology: Medicine Sciences, 56(8), M477–M482.
Jabaaij, L., van Hattum, J., Vingerhoets, J. J. M., Oostveen, F. G., Duivenvoorden, H. J., Ballieux, R. E. (1996). Modulation of immune response to rDNA hepatitis B vaccination by psychological stress. Journal of Psychosomatic Research, 41(2), 129–137.
Kang, D., Rice, M., Park, N., Turner-Henson, A., & Downs, C. (2010). Stress and inflammation: A biobehavioral approach for nursing research. Western Journal of Nursing Research, 32(6), 730–760.
Kiecolt-Glaser, J. K., Marucha, P. T., Mercado, A. M., Glaser, R. (1995). Slowing of wound healing by psychological stress. The Lancet, 346, 1194–1196.
Kiecolt-Glaser, J. K., Glaser, R., Gravenstein, S., Malarkey, W. B., & Sheridan, J. (1996). Chronic stress alters the immune response to influenza virus vaccine in older adults. Proceedings of the National Academy of Sciences, United States of America, 93, 3043–3047.
Padgett, D. A., Sheridan, J. F., Dorne, J., Bernston, G. G., Candelora, J., & Glaser, R. (1998). Social stress and the reactivation of latent herpes simplex virus type 1. Proceedings of the National Academy of Sciences of the United States of America, 95, 7231–7235.
Padgett, D. A., & Glaser, R. (2003). How stress influences the immune response. TRENDS in Immunology, 24(8), 444–448.
Rabin, B. S. (1999). Stress, immune function, and health: The connection. New York, NY: Wiley Liss.
Segerstrom, S. C., & Miller, G. E. (2004). Psychological stress and the human immune system: A meta-analytic study of 30 years of inquiry. Psychological Bulletin, 130(4), 601–630.
Selye, H. (1952). The story of the adaptation syndrome. Montreal, Canada: Acta.
Vedhara, K., Cox, N. K., Wilcock, G. K., Perks, P., Hunt, M., Anderson, S., et al. (1999). Chronic stress in elderly carers of dementia patients and antibody response to influenza vaccination. Lancet, 353(9153), 627–631.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media, New York
About this entry
Cite this entry
Benedict, C. (2013). Biobehavioral Mechanisms. In: Gellman, M.D., Turner, J.R. (eds) Encyclopedia of Behavioral Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1005-9_153
Download citation
DOI: https://doi.org/10.1007/978-1-4419-1005-9_153
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4419-1004-2
Online ISBN: 978-1-4419-1005-9
eBook Packages: MedicineReference Module Medicine