Image-Guided High-Intensity Focused Ultrasound in the Treatment of Cancer

  • M. Raphael Pfeffer
  • Tatiana Rabin
  • Yael Inbar
  • Arik Hananel
  • Raphael Catane
Reference work entry


High-intensity focused ultrasound (HIFU) is a noninvasive technique delivering acoustic energy for localized thermal ablation of tumors. The targeted volume reaches temperatures above 70 °C within a fraction of a second resulting in coagulative necrosis and ablation of the target and minimal side effects to nontargeted tissues. Available systems use either ultrasound or magnetic resonance imaging (MRI) to define the target and guide the treatment. MR-guided HIFU has the additional advantage of real-time thermometry which allows measurement and adjustment of the deposited energy during therapy. Several HIFU devices are commercially available, and the clinical use of HIFU is approved in many countries for the treatment of benign uterine fibroids and for the treatment of adenomyosis and painful bone metastases. Clinical studies are investigating the use of MR-guided HIFU for the treatment of painful bone metastases, primary breast cancer, and primary prostate cancer. Ultrasound-guided transrectal HIFU devices are in use in several countries to treat benign prostatic hypertrophy as well as primary and locally recurrent prostate cancer. The use of HIFU in cancer treatment is expanding due to advances in technology and accumulating clinical experience. In this chapter, we will review the technology and clinical experience of HIFU in cancer treatment.


Prostate Cancer Bone Metastasis Coagulative Necrosis Recurrent Prostate Cancer HIFU Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • M. Raphael Pfeffer
    • 1
  • Tatiana Rabin
    • 1
  • Yael Inbar
    • 2
  • Arik Hananel
    • 3
  • Raphael Catane
    • 1
  1. 1.Oncology Institute, Sheba Medical CenterTel HashomerIsrael
  2. 2.Imaging Institute, Sheba Medical CenterTel HashomerIsrael
  3. 3.Insightec Ltd.Tirat CarmelIsrael

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