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Focal Therapy of Prostate Cancer by Radiofrequency and Photodynamic Therapy

  • Bob Djavan
  • Herbert Lepor
  • Reza Zare
  • Seyed Saeid Dianat
Reference work entry

Abstract

Prostate cancer is still the most common noncutaneous cancer in male. It is estimated that 217,730 new cases of prostate cancer will be diagnosed, and 32,050 prostate cancer-related deaths will occur in the United States in 2010. Focal therapeutic techniques offer a middle way between the radical surgery and active surveillance in the management of prostate cancer. Two major developments in this field are improvements in tumor localization techniques and new ablative therapies such as high-intensity focused ultrasound (HIFU), cryosurgery, photodynamic therapy, photothermal therapy, and radiofrequency interstitial tumor ablation (RITA) enabling a precise and accurate ablation of tumor foci. RITA therapy is a focal therapeutic modality in which low-level radiofrequency energy is precisely delivered to the target tissue to heat and ablate the malignant tissue. RF energy generates temperatures of around 100 °C and induces irreversible cellular destruction by coagulative necrosis. This chapter reviews the concept of focal therapy for prostate cancer, image-guided biopsy, and the role of imaging before focal therapy and more specifically considers the equipments, procedural technique, and the efficacy of radiofrequency ablation for local prostate cancer. Finally, we briefly reviewed the contribution of photodynamic therapy for the treatment of prostate cancer.

Keywords

Prostate Cancer Radical Prostatectomy Gleason Score Light Dose Focal Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Bob Djavan
    • 1
  • Herbert Lepor
    • 2
  • Reza Zare
    • 1
  • Seyed Saeid Dianat
    • 1
  1. 1.Department of UrologyNew York University VA University HospitalNew YorkUSA
  2. 2.Department of UrologyNew York University Langone Medical CenterNew YorkUSA

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