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Image-Guided Cancer Therapy pp 607–616Cite as

Chemotherapy for the Lungs

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Abstract

The addition of chemotherapy to definitive radiation for both non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) improves survival. Although the initial data for superior survival with chemotherapy came from studies using induction chemotherapy before definitive radiation, subsequent studies have shown superior outcomes with concurrent therapy. The combination of cisplatin and etoposide remains the standard of care for patients able to tolerate the regimen. In the context of concurrent definitive chemoradiation with full dose chemotherapy, there is no proven benefit to additional chemotherapy given either before or after chemoradiation. However, consolidation with full dose therapy remains standard following low-dose regimens used for patients unable to tolerate cisplatin and etoposide. Perhaps, the most accepted of these regimens is the locally advanced multimodality protocol (LAMP) regimen of weekly carboplatin and paclitaxel, which in Japan proved equivalent to a cisplatin-containing regimen in combination with radiation. The combination of full dose carboplatin and pemetrexed is also of increasing interest for patients with non-squamous histology. No targeted agent is currently indicated in combination with radiation.

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Author information

Authors and Affiliations

  1. Department of Medicine, Division of Hematology-Oncology, Hospital of the University of Pennsylvania, 3400 Civic Center Boulevard, PCAM2, Philadelphia, PA, 19104, USA

    Corey J. Langer

  2. Department of Medicine, Division of Hematology-Oncology, University of North Carolina at Chapel Hill, 170 Manning Drive, Room 3115, 7305, Chapel Hill, NC, 27599, USA

    Jared Weiss

Authors
  1. Corey J. Langer
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  2. Jared Weiss
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Corresponding author

Correspondence to Corey J. Langer .

Editor information

Editors and Affiliations

  1. The Warren Alpert Medical School of Brown University, Department of Diagnostic Imaging Rhode Island Hospital, Providence, Rhode Island, USA

    Damian E. Dupuy

  2. Department of Surgery and Radiology Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Yuman Fong

  3. McMullen Consulting, LLC, Surprise, Arizona, USA

    William N. McMullen

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© 2013 Springer Science+Business Media New York

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Langer, C.J., Weiss, J. (2013). Chemotherapy for the Lungs. In: Dupuy, D., Fong, Y., McMullen, W. (eds) Image-Guided Cancer Therapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0751-6_43

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  • DOI: https://doi.org/10.1007/978-1-4419-0751-6_43

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-0750-9

  • Online ISBN: 978-1-4419-0751-6

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