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Percutaneous Interventional Radiology: The Lung

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Image-Guided Cancer Therapy

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Abstract

Percutaneous ablation techniques have emerged as a viable treatment option for primary and secondary lung malignancies. Utilizing minimally invasive image-guided approaches, these techniques allow for the precise placement of ablation devices with the goal of total tumor necrosis and local control, offering in some instances curative potential. The different ablative technologies used in the thorax are based on application of thermal energies, chemical lysis, and alteration of cell permeability, the thermal energies most extensively studied thus far. These ablative techniques provide a valuable stand-alone alternative to conventional surgical resection or an adjunct to surgery, chemotherapy, or radiotherapy. The development of these and additional novel therapies has resulted in a multidisciplinary approach for the treatment of primary and secondary pulmonary malignancies with percutaneous ablative techniques proving to be a robust therapeutic option. To date, radiofrequency ablation (RFA) is the best developed and most widely used thermal ablation technique in the lung. Using radiofrequency ablation as a model for thermal ablation, this chapter will outline the principles of thermal ablation, the role of thermal ablation in the treatment of primary and secondary pulmonary malignancies, the procedural-related complications of thermal ablation within the lung, post-ablation follow-up and treatment results, as well as a brief discussion and comparison of the different ablative technologies.

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Authors and Affiliations

  1. Department of Radiological Sciences, Ronald Reagan UCLA Medical Center, 757 Westwood Drive, Suite 1638C, Los Angeles, CA, 90095, USA

    Kien Vuu, Antonio Gutierrez, Fereidoun Abtin & Robert Suh

  2. Department of Radiology, Body Division, Keck School of Medicine USC University Hospital, 1500 San Pablo Street, Fl. 2 (Imaging), Los Angeles, CA, 90033, USA

    Christopher Lee

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  1. Kien Vuu
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  2. Antonio Gutierrez
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  3. Fereidoun Abtin
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  4. Christopher Lee
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  5. Robert Suh
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Corresponding author

Correspondence to Kien Vuu .

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Editors and Affiliations

  1. The Warren Alpert Medical School of Brown University, Department of Diagnostic Imaging Rhode Island Hospital, Providence, Rhode Island, USA

    Damian E. Dupuy

  2. Department of Surgery and Radiology Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Yuman Fong

  3. McMullen Consulting, LLC, Surprise, Arizona, USA

    William N. McMullen

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Vuu, K., Gutierrez, A., Abtin, F., Lee, C., Suh, R. (2013). Percutaneous Interventional Radiology: The Lung. In: Dupuy, D., Fong, Y., McMullen, W. (eds) Image-Guided Cancer Therapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0751-6_39

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  • DOI: https://doi.org/10.1007/978-1-4419-0751-6_39

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