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Irreversible Electroporation in Liver Tumor

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Image-Guided Cancer Therapy

Abstract

As cancer-related deaths continue to increase around the world, providing an effective and cost-efficient treatment remains a top priority. Specifically in relation to ablation techniques, one such modality that is receiving increased attention is irreversible electroporation (IRE). In recent years, IRE has elicited excitement as a potential treatment for malignant tumors due to its advantages of utilizing nonthermal energy, achieving complete cell death and the ability to image the effects in near real time. In this chapter, we will discuss a brief overview of IRE in liver ablation.

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References

  1. Lee RC. Cell injury by electric forces. Ann N Y Acad Sci. 2005;1066:85–91.

    Article  CAS  PubMed  Google Scholar 

  2. Gaylor DC, Prakah-Asante K, Lee RC. Significance of cell size and tissue structure in electrical trauma. J Theor Biol. 1988;133(2):223–37.

    Article  CAS  PubMed  Google Scholar 

  3. Gabriel B, Teissie J. Direct observation in the millisecond time range of fluorescent molecule asymmetrical interaction with the electropermeabilized cell membrane. Biophys J. 1997;73(5):2630–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Teissie J, Rols MP. An experimental evaluation of the critical potential difference inducing cell membrane electropermeabilization. Biophys J. 1993;65(1):409–13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Rols MP. Electropermeabilization, a physical method for the delivery of therapeutic molecules into cells. Biochim Biophys Acta. 2006;1758(3):423–8.

    Article  CAS  PubMed  Google Scholar 

  6. Davalos RV, Mir IL, Rubinsky B. Tissue ablation with irreversible electroporation. Ann Biomed Eng. 2005;33(2):223–31.

    Article  CAS  PubMed  Google Scholar 

  7. Lee EW, Loh CT, Kee ST. Imaging guided percutaneous irreversible electroporation: ultrasound and immunohistological correlation. Technol Cancer Res Treat. 2007;6(4):287–94.

    Article  PubMed  Google Scholar 

  8. Lee EW, et al. Advanced hepatic ablation technique for creating complete cell death: irreversible electroporation. Radiology. 2010;255(2):426–33.

    Article  PubMed  Google Scholar 

  9. Chapentier KP, et al. Irreversible electroporation of the liver and liver hilum in swine. HPB. 2011;13(1):168–73.

    Article  Google Scholar 

  10. Lee YJ. et al. Irreversible electroporation in porcine liver: short and long term effects on hepatic veins and adjacent tissue by CT with pathological correlation. Proceedings of the WCIO Annual Meeting, Philadelphia; 2010.

    Google Scholar 

  11. Choi JW, et al. Assessment of short and long term effects of irreversible electroporation on Hilar bile ducts in a porcine model. Proceedings of the SIR Annual Meeting, Philaelphia; 2011.

    Google Scholar 

  12. Lu DS, et al. Irreversible electroporation in porcine Liver: lesion appearance on CT with pathological correlation. Proceedings of the WCIO Annual Meeting, Philadelphia; 2010.

    Google Scholar 

  13. Guo Y, et al. Irreversible electroporation therapy in the liver: longitudinal efficacy studies in a rat model of hepatocellular carcinoma. Cancer Res. 2010;70(4):1555–63.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Guo Y, et al. Irreversible electroporation in the liver: contrast-enhanced inversion-recovery MR imaging approaches to differentiate reversibly electroporated penumbra from irreversibly electroporated ablation zones. Radiology. 2011;258(2):461–8.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Thomson KR, et al. Investigation of the safety of irreversible electroporation in humans. J Vasc Interv Radiol. 2011;22(5):611–21.

    Article  PubMed  Google Scholar 

  16. Narayanan G, et al. Safety and efficacy of irreversible electroporation in the treatment of primary HCC. In: SIR 36th Annual scientific meeting 2011. Chicago: J Vasc Inter Radiol.

    Google Scholar 

  17. Charpentier KP, et al. Irreversible electroporation of the pancreas in swine: a pilot study. HPB (Oxford). 2010;12(5):348–51.

    Article  Google Scholar 

  18. Ball C, Thomson KR, Kavnoudias H. Irreversible electroporation: a new challenge in “out of operating theater” anesthesia. Anesth Analg. 2010;110(5):1305–9.

    Article  PubMed  Google Scholar 

  19. Mali B, et al. The effect of electroporation pulses on functioning of the heart. Med Biol Eng Comput. 2008;46(8):745–57.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Deodhar A, et al. Irreversible electroporation near the heart: ventricular arrhythmias can be prevented with ECG synchronization. AJR Am J Roentgenol. 2011;196(3):W330–5.

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Edward Wolfgang Lee .

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© 2013 Springer Science+Business Media New York

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Lee, E.W., Wong, D., Kee, S.T. (2013). Irreversible Electroporation in Liver Tumor. In: Dupuy, D., Fong, Y., McMullen, W. (eds) Image-Guided Cancer Therapy. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0751-6_37

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  • DOI: https://doi.org/10.1007/978-1-4419-0751-6_37

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-0750-9

  • Online ISBN: 978-1-4419-0751-6

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