Y-90 Radiomicrosphere Therapy of Colorectal Cancer: Liver Metastases

  • Seza A. Gulec
  • Tushar C. Barot
Reference work entry


Our objective is to discuss the basic concepts involved in the development of yttrium-90 (Y-90) microsphere selective internal radiation treatment (SIRT) and review the clinical data pertaining to its application in hepatic colorectal cancer metastases. Selective internal radiation treatment is a promising new modality in the treatment of patients with hepatic colorectal cancer metastases as part of a multimodality approach. A chemoselective internal radiation treatment neoadjuvant approach has the potential to improve therapeutic outcomes. Clinical studies in neoadjuvant and salvage settings are needed for more concrete outcome data and design of optimal multimodality treatment strategies. This chapter will discuss the principles of Y-90 therapy, pretreatment evaluation of patients including various imaging techniques, treatment technique studies, and potential complications of radiomicrosphere therapy. It will also review studies previously done in the field of radiomicrosphere therapy.


Portal Vein Embolization Future Liver Remnant Radiation Pneumonitis Resin Microsphere Salvage Setting 
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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Surgical OncologyThe Herbert Wertheim College of Medicine Florida International UniversityMiamiUSA
  2. 2.Mount Sinai Medical CenterMiami BeachUSA

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