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Viral-Like Proteins

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Cancer Therapeutic Targets

Abstract

Cancer immunotherapy is a rapidly evolving field and the search for appropriate targets to come up with robust immunotherapeutic strategies for the treatment of cancers is a continuous process. Viral-like proteins are known to have an important role in the oncogenesis and their potential as cancer therapeutic targets is yet to be completely explored. In this report we summarized different aspects of viral-like proteins such as their biology, their role in cancer and gave an insight into strategies that can be adopted to target these proteins for the treatment of cancer.

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References

  • Amado RG, et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol. 2008;26(10):1626–34.

    Article  CAS  PubMed  Google Scholar 

  • Armbruester V, et al. A novel gene from the human endogenous retrovirus K expressed in transformed cells. Clin Cancer Res. 2002;8(6):1800–7.

    CAS  PubMed  Google Scholar 

  • Bannert N, Kurth R. Retroelements and the human genome: new perspectives on an old relation. Proc Natl Acad Sci U S A. 2004;101 Suppl 2:14572–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bannert N, Kurth R. The evolutionary dynamics of human endogenous retroviral families. Annu Rev Genomics Hum Genet. 2006;7:149–73.

    Article  CAS  PubMed  Google Scholar 

  • Bera TK, et al. Defective retrovirus insertion activates c-Ha-ras protooncogene in an MNU-induced rat mammary carcinoma. Biochem Biophys Res Commun. 1998;248(3):835–40.

    Article  CAS  PubMed  Google Scholar 

  • Bergo MO, et al. Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation. Mol Cell Biol. 2002;22(1):171–81.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bergo MO, et al. Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf. J Clin Invest. 2004;113(4):539–50.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bister K, Jansen HW. Oncogenes in retroviruses and cells: biochemistry and molecular genetics. Adv Cancer Res. 1986;47:99–188.

    Article  CAS  PubMed  Google Scholar 

  • Bjerregaard B, et al. Syncytin is involved in breast cancer-endothelial cell fusions. Cell Mol Life Sci. 2006;63(16):1906–11.

    Article  CAS  PubMed  Google Scholar 

  • Boggon TJ, Eck MJ. Structure and regulation of Src family kinases. Oncogene. 2004;23(48):7918–27.

    Article  CAS  PubMed  Google Scholar 

  • Brazil DP, Hemmings BA. Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem Sci. 2001;26(11):657–64.

    Article  CAS  PubMed  Google Scholar 

  • Britten RJ, Davidson EH. Repetitive and non-repetitive DNA sequences and a speculation on the origins of evolutionary novelty. Q Rev Biol. 1971;46(2):111–38.

    Article  CAS  PubMed  Google Scholar 

  • Buscher K, et al. Expression of human endogenous retrovirus K in melanomas and melanoma cell lines. Cancer Res. 2005;65(10):4172–80.

    Article  PubMed  Google Scholar 

  • Cacev T, et al. NF1 gene loss of heterozygosity and expression analysis in sporadic colon cancer. Gut. 2005;54(8):1129–35.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Carlini F, et al. The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines. PLoS One. 2010;5(12):e14221.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen T, et al. The viral oncogene Np9 acts as a critical molecular switch for co-activating beta-catenin, ERK, Akt and Notch1 and promoting the growth of human leukemia stem/progenitor cells. Leukemia. 2013;27(7):1469–78.

    Article  CAS  PubMed  Google Scholar 

  • Contreras-Galindo R, et al. Human endogenous retrovirus K (HML-2) elements in the plasma of people with lymphoma and breast cancer. J Virol. 2008;82(19):9329–36.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Davies H, et al. Mutations of the BRAF gene in human cancer. Nature. 2002;417(6892):949–54.

    Article  CAS  PubMed  Google Scholar 

  • Deininger PL, Batzer MA. Mammalian retroelements. Genome Res. 2002;12(10):1455–65.

    Article  CAS  PubMed  Google Scholar 

  • Denayer E, de Ravel T, Legius E. Clinical and molecular aspects of RAS related disorders. J Med Genet. 2008;45(11):695–703.

    Article  CAS  PubMed  Google Scholar 

  • Denne M, et al. Physical and functional interactions of human endogenous retrovirus proteins Np9 and rec with the promyelocytic leukemia zinc finger protein. J Virol. 2007;81(11):5607–16.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Depil S, et al. Expression of a human endogenous retrovirus, HERV-K, in the blood cells of leukemia patients. Leukemia. 2002;16(2):254–9.

    Article  CAS  PubMed  Google Scholar 

  • Der CJ, Krontiris TG, Cooper GM. Transforming genes of human bladder and lung carcinoma cell lines are homologous to the ras genes of Harvey and Kirsten sarcoma viruses. Proc Natl Acad Sci U S A. 1982;79(11):3637–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dhomen N, Marais R. New insight into BRAF mutations in cancer. Curr Opin Genet Dev. 2007;17(1):31–9.

    Article  CAS  PubMed  Google Scholar 

  • Downward J. Lipid-regulated kinases: some common themes at last. Science. 1998;279(5351):673–4.

    Article  CAS  PubMed  Google Scholar 

  • Fensterer H, et al. Expression profiling of the influence of RAS mutants on the TGFB1-induced phenotype of the pancreatic cancer cell line PANC-1. Genes Chromosomes Cancer. 2004;39(3):224–35.

    Article  CAS  PubMed  Google Scholar 

  • Frame MC. Src in cancer: deregulation and consequences for cell behaviour. Biochim Biophys Acta. 2002;1602(2):114–30.

    CAS  PubMed  Google Scholar 

  • Franke TF, et al. PI3K/Akt and apoptosis: size matters. Oncogene. 2003;22(56):8983–98.

    Article  CAS  PubMed  Google Scholar 

  • Frendo JL, et al. Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation. Mol Cell Biol. 2003;23(10):3566–74.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gasent Blesa J, Candel V. Cell-cell fusion as a potential target in cancer therapy. Ecancermedicalscience. 2009;3:145.

    PubMed  PubMed Central  Google Scholar 

  • Giehl K. Oncogenic Ras in tumour progression and metastasis. Biol Chem. 2005;386(3):193–205.

    CAS  PubMed  Google Scholar 

  • Golde A. Radio-induced mutants of the Schmidt-Ruppin strain of rous sarcoma virus. Virology. 1970;40(4):1022–9.

    Article  CAS  PubMed  Google Scholar 

  • Herrera R, Sebolt-Leopold JS. Unraveling the complexities of the Raf/MAP kinase pathway for pharmacological intervention. Trends Mol Med. 2002;8(4 Suppl):S27–31.

    Article  CAS  PubMed  Google Scholar 

  • Howe LR, et al. Activation of the MAP kinase pathway by the protein kinase raf. Cell. 1992;71(2):335–42.

    Article  CAS  PubMed  Google Scholar 

  • Huebner RJ, Todaro GJ. Oncogenes of RNA tumor viruses as determinants of cancer. Proc Natl Acad Sci U S A. 1969;64(3):1087–94.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Irby RB, Yeatman TJ. Role of Src expression and activation in human cancer. Oncogene. 2000;19(49):5636–42.

    Article  CAS  PubMed  Google Scholar 

  • Kaufmann S, et al. Human endogenous retrovirus protein Rec interacts with the testicular zinc-finger protein and androgen receptor. J Gen Virol. 2010;91(Pt 6):1494–502.

    Article  CAS  PubMed  Google Scholar 

  • Kettmann R, et al. Leukemogenesis by bovine leukemia virus: proviral DNA integration and lack of RNA expression of viral long terminal repeat and 3′ proximate cellular sequences. Proc Natl Acad Sci U S A. 1982;79(8):2465–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Khosravi-Far R, et al. Increasing complexity of Ras signal transduction: involvement of Rho family proteins. Adv Cancer Res. 1998;72:57–107.

    Article  CAS  PubMed  Google Scholar 

  • Khoukaz T. Administration of anti-EGFR therapy: a practical review. Semin Oncol Nurs. 2006;22(1 Suppl 1):20–7.

    Article  PubMed  Google Scholar 

  • Kidwell MG, Lisch D. Transposable elements as sources of variation in animals and plants. Proc Natl Acad Sci U S A. 1997;94(15):7704–11.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kudo Y, Boyd CA. Changes in expression and function of syncytin and its receptor, amino acid transport system B(0) (ASCT2), in human placental choriocarcinoma BeWo cells during syncytialization. Placenta. 2002;23(7):536–41.

    Article  CAS  PubMed  Google Scholar 

  • Landriscina M, et al. Nevirapine restores androgen signaling in hormone-refractory human prostate carcinoma cells both in vitro and in vivo. Prostate. 2009;69(7):744–54.

    Article  CAS  PubMed  Google Scholar 

  • Landry JR, Mager DL. Functional analysis of the endogenous retroviral promoter of the human endothelin B receptor gene. J Virol. 2003;77(13):7459–66.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Landry JR, et al. The Opitz syndrome gene Mid1 is transcribed from a human endogenous retroviral promoter. Mol Biol Evol. 2002;19(11):1934–42.

    Article  CAS  PubMed  Google Scholar 

  • Larsson LI, Holck S, Christensen IJ. Prognostic role of syncytin expression in breast cancer. Hum Pathol. 2007;38(5):726–31.

    Article  CAS  PubMed  Google Scholar 

  • Maeda N, Fan H, Yoshikai Y. Oncogenesis by retroviruses: old and new paradigms. Rev Med Virol. 2008;18(6):387–405.

    Article  CAS  PubMed  Google Scholar 

  • Mangiacasale R, et al. Exposure of normal and transformed cells to nevirapine, a reverse transcriptase inhibitor, reduces cell growth and promotes differentiation. Oncogene. 2003;22(18):2750–61.

    Article  CAS  PubMed  Google Scholar 

  • Marchuk DA, et al. cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product. Genomics. 1991;11(4):931–40.

    Article  CAS  PubMed  Google Scholar 

  • Martin GS. Rous sarcoma virus: a function required for the maintenance of the transformed state. Nature. 1970;227(5262):1021–3.

    Article  CAS  PubMed  Google Scholar 

  • Mayer J, et al. Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity. Virology. 2004;322(1):190–8.

    Article  CAS  PubMed  Google Scholar 

  • McDonald JF. Evolution and consequences of transposable elements. Curr Opin Genet Dev. 1993;3(6):855–64.

    Article  CAS  PubMed  Google Scholar 

  • Medstrand P, van de Lagemaat LN, Mager DL. Retroelement distributions in the human genome: variations associated with age and proximity to genes. Genome Res. 2002;12(10):1483–95.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mikkelsen TS, et al. Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature. 2007;447(7141):167–77.

    Article  CAS  PubMed  Google Scholar 

  • Mortensen K, et al. Spontaneous fusion between cancer cells and endothelial cells. Cell Mol Life Sci. 2004;61(16):2125–31.

    Article  CAS  PubMed  Google Scholar 

  • Mullins CS, Linnebacher M. Endogenous retrovirus sequences as a novel class of tumor-specific antigens: an example of HERV-H env encoding strong CTL epitopes. Cancer Immunol Immunother. 2012;61(7):1093–100.

    Article  CAS  PubMed  Google Scholar 

  • Norberg S, Powell TL, Jansson T. Intrauterine growth restriction is associated with a reduced activity of placental taurine transporters. Pediatr Res. 1998;44(2):233–8.

    Article  CAS  PubMed  Google Scholar 

  • Parada LF, et al. Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene. Nature. 1982;297(5866):474–8.

    Article  CAS  PubMed  Google Scholar 

  • Rajalingam K, et al. Ras oncogenes and their downstream targets. Biochim Biophys Acta. 2007;1773(8):1177–95.

    Article  CAS  PubMed  Google Scholar 

  • Ross PJ, et al. Inhibition of Kirsten-ras expression in human colorectal cancer using rationally selected Kirsten-ras antisense oligonucleotides. Mol Cancer Ther. 2001;1(1):29–41.

    CAS  PubMed  Google Scholar 

  • Santos E, et al. T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes. Nature. 1982;298(5872):343–7.

    Article  CAS  PubMed  Google Scholar 

  • Sciamanna I, et al. Inhibition of endogenous reverse transcriptase antagonizes human tumor growth. Oncogene. 2005;24(24):3923–31.

    Article  CAS  PubMed  Google Scholar 

  • Shalloway D, Zelenetz AD, Cooper GM. Molecular cloning and characterization of the chicken gene homologous to the transforming gene of Rous sarcoma virus. Cell. 1981;24(2):531–41.

    Article  CAS  PubMed  Google Scholar 

  • Sorek R, Ast G, Graur D. Alu-containing exons are alternatively spliced. Genome Res. 2002;12(7):1060–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Stehelin D, et al. DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA. Nature. 1976;260(5547):170–3.

    Article  CAS  PubMed  Google Scholar 

  • Stites EC, Ravichandran KS. A systems perspective of ras signaling in cancer. Clin Cancer Res. 2009;15(5):1510–3.

    Article  CAS  PubMed  Google Scholar 

  • Stoye JP, Coffin JM. A provirus put to work. Nature. 2000;403(6771):715. 717.

    Article  CAS  PubMed  Google Scholar 

  • Strick R, et al. Proliferation and cell-cell fusion of endometrial carcinoma are induced by the human endogenous retroviral Syncytin-1 and regulated by TGF-beta. J Mol Med (Berl). 2007;85(1):23–38.

    Article  CAS  Google Scholar 

  • Suliman BA, Xu D, Williams BR. The promyelocytic leukemia zinc finger protein: two decades of molecular oncology. Front Oncol. 2012;2:74.

    Article  PubMed  PubMed Central  Google Scholar 

  • Takeya T, Hanafusa H. Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus. Cell. 1983;32(3):881–90.

    Article  CAS  PubMed  Google Scholar 

  • Tartaglia M, et al. Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Nat Genet. 2001;29(4):465–8.

    Article  CAS  PubMed  Google Scholar 

  • Tidyman WE, Rauen KA. The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation. Curr Opin Genet Dev. 2009;19(3):230–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Toyoshima K, Friis RR, Vogt PK. The reproductive and cell-transforming capacities of avian sarcoma virus B77: inactivation with UV light. Virology. 1970;42(1):163–70.

    Article  CAS  PubMed  Google Scholar 

  • van de Lagemaat LN, et al. Transposable elements in mammals promote regulatory variation and diversification of genes with specialized functions. Trends Genet. 2003;19(10):530–6.

    Article  PubMed  Google Scholar 

  • Wang T, et al. Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53. Proc Natl Acad Sci U S A. 2007;104(47):18613–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang-Johanning F, et al. Immunotherapeutic potential of anti-human endogenous retrovirus-K envelope protein antibodies in targeting breast tumors. J Natl Cancer Inst. 2012;104(3):189–210.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Keith L. Knutson .

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Karyampudi, L., Knutson, K.L. (2017). Viral-Like Proteins. In: Marshall, J. (eds) Cancer Therapeutic Targets. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0717-2_147

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