Benign Diseases of the Endometrium

Abstract

The endometrium and the myometrium are of mesodermal origin and are formed secondary to fusion of the müllerian (paramesonephric) ducts between the 8th and 9th postovulatory weeks. The cervix is generally considered to be of müllerian origin, although it has been claimed that its mucous membrane is derived from the urogenital sinus; however, the exact contribution of müllerian and sinus tissue to the cervix remains uncertain [47]. Until the 20th week of gestation, the endometrium consists of a single layer of columnar epithelium supported by a thick layer of fibroblastic stroma. After the 20th gestational week, the surface epithelium invaginates into the underlying stroma, forming glandular structures that extend toward the underlying myometrium. At birth, the uterus, which is made up of the uterine corpus and uterine cervix, measures approximately 4 cm in length, the majority of which is made up of the cervix. The endometrium measures less than 0.5 mm in thickness, and the surface and glands are lined by a low columnar to cuboidal epithelium devoid of either proliferative or secretory activity, which resembles the inactive endometrium of postmenopausal women.

Keywords

Adenocarcinoma Androgen Perforation Sarcoidosis Taxanes 

References

  1. 1.
    Antoni J, Folch E, Costa J et al (1997) Comparison of cystopat and pipelle endometrial biopsy instruments. Eur J Obstet Gynecol Reprod Biol 72:57–61PubMedCrossRefGoogle Scholar
  2. 2.
    Archer DF, McIntyre-Seltman K, Wilborn WW Jr et al (1991) Endometrial morphology in asymptomatic postmenopausal women. Am J Obstet Gynecol 165:317–320PubMedGoogle Scholar
  3. 3.
    Arias-Stella J Jr, Arias-Velasquez A, Arias-Stella J (1994) Normal and abnormal mitoses in the atypical endometrial change associated with chorionic tissue effect. Am J Surg Pathol 18:694–701PubMedCrossRefGoogle Scholar
  4. 4.
    Arias-Stella J (2002) The Arias-Stella reaction: facts and fancies four decades after. Adv Anat Pathol 9:12–23PubMedCrossRefGoogle Scholar
  5. 5.
    Bahceci M, Demirel LC (1996) Osseous metaplasia of the endometrium: a rare cause of infertility and its hysteroscopic management. Hum Reprod 11:2537–2539PubMedCrossRefGoogle Scholar
  6. 6.
    Baird DB, Reddick RL (1991) Extraovarian mucinous metaplasia in a patient with bilateral mucinous borderline ovarian tumors: a case report. Int J Gynecol Pathol 10:96–103PubMedCrossRefGoogle Scholar
  7. 7.
    Bakour SH, Khan KS, Gupta JK (2000) Controlled analysis of factors associated with insufficient sample on outpatient endometrial biopsy. Br J Obstet Gynaecol 107:1312–1314CrossRefGoogle Scholar
  8. 8.
    Banks ER, Mills SE, Frierson HF Jr (1991) Uterine intravascular menstrual endometrium simulating malignancy. Am J Surg Pathol 15:407–412PubMedCrossRefGoogle Scholar
  9. 9.
    Barroeta JE, Pasha TL, Acs G et al (2007) Immunoprofile of endometrial and endocervical stromal cells and its potential application in localization of tumour involvement. Int J Gynecol Pathol 26:76–82PubMedCrossRefGoogle Scholar
  10. 10.
    Bayer-Garner IB, Korourian S (2001) Plasma cells in chronic endometritis are easily identified when stained with syndecan-1. Mod Pathol 14:877–879PubMedCrossRefGoogle Scholar
  11. 11.
    Bayer-Garner IB, Nickell JA (2004) Routine syndecan-1 immunohistochemistry aids in the diagnosis of chronic endometritis. Arch Pathol Lab Med 128:1000–1003PubMedGoogle Scholar
  12. 12.
    Bennett AE, Rathmore S, Rhatigan RM (1999) Focal necrotizing endometritis: a clinicopathologic study of 15 cases. Int J Gynecol Pathol 18:220–225PubMedCrossRefGoogle Scholar
  13. 13.
    Bozdogan O, Atasoy P, Erekul S et al (2002) Apoptosis-related proteins and steroid hormone receptors in normal, hyperplastic and neoplastic endometrium. Int J Gynecol Pathol 21:375–382PubMedCrossRefGoogle Scholar
  14. 14.
    Brachtel EF, Sánchez-Estevez C, Moreno-Bueno G et al (2005) Distinct molecular alterations in complex endometrial hyperplasia (CEH) with and without immature squamous metaplasia (squamous morules). Am J Surg Pathol 29:1322–1329PubMedCrossRefGoogle Scholar
  15. 15.
    Brinton LA, Hoover RN, Endometrial Cancer Collaborative Group (1993) Estrogen replacement therapy and endometrial cancer risk: a meta-analysis. Obstet Gynecol 81:265–271PubMedGoogle Scholar
  16. 16.
    Bulmer JN, Hollings D, Ritson A (1987) Immunocytochemical evidence that endometrial stromal granulocytes are granulated lymphocytes. J Pathol 155:281–287CrossRefGoogle Scholar
  17. 17.
    Bulmer JN, Lunny DP, Hagin SV (1988) Immunohistochemical characterization of stromal leucocytes in non-pregnant human endometrium. Am J Reprod Immunol Microbiol 17:83–90PubMedGoogle Scholar
  18. 18.
    Carlson JW, Mutter GL (2008) Endometrial intraepithelial neoplasia is associated with polyps and frequently has metaplastic change. Histopathology 53:325–332PubMedCrossRefGoogle Scholar
  19. 19.
    Cheng WF, Lin HH, Torng PL, Huang SC (1997) Comparison of endometrial changes among symptomatic tamoxifen-treated and non-treated premenopausal and postmenopausal breast cancer patients. Gynecol Oncol 66:233–237PubMedCrossRefGoogle Scholar
  20. 20.
    Chiarelli S, Buriticá C, Litta P et al (2006) An immunohistochemical study of morules in endometrioid lesions of the female genital tract: CD10 is a characteristic marker of morular metaplasia. Clin Cancer Res 12:4251–4256PubMedCrossRefGoogle Scholar
  21. 21.
    Chinen K, Kamiyama K, Kinjo T et al (2004) Morules in endometrial carcinoma and benign endometrial lesions differ from squamous differentiation tissue and are not infected with human papillomavirus. J Clin Pathol 57:918–926PubMedCrossRefGoogle Scholar
  22. 22.
    Clark TJ, Mann CH, Shah N et al (2001) Accuracy of outpatient endometrial biopsy in the diagnosis of endometrial hyperplasia. Acta Obstet Gynecol Scand 80:784–793PubMedCrossRefGoogle Scholar
  23. 23.
    Clement PB, Young RH (1987) Atypical polypoid adenomyoma of the uterus associated with Turner’s syndrome. Int J Gynecol Pathol 6:104–113PubMedCrossRefGoogle Scholar
  24. 24.
    Clement PB, Scully RE (1988) Idiopathic postmenopausal decidual reaction of the endometrium. Int J Gynecol Pathol 7:152–161PubMedCrossRefGoogle Scholar
  25. 25.
    Clement PB (1988) Postoperative spindle-cell nodule of the endometrium. Arch Pathol Lab Med 112:566–568PubMedGoogle Scholar
  26. 26.
    Clement PB, Scully RE (1990) Mullerian adenosarcoma of the uterus: a clinicopathologic analysis of 100 cases and review of the literature. Hum Pathol 21:363–381PubMedCrossRefGoogle Scholar
  27. 27.
    Clement PB, Oliva E, Young RH (1996) Mullerian adenosarcoma of the uterine corpus associated with tamoxifen therapy: a report of six cases and a review of tamoxifen – associated endometrial lesions. Int J Gynecol Pathol 15:222–229PubMedCrossRefGoogle Scholar
  28. 28.
    Cohen I, Figer A, Altaras MM et al (1996) Common endometrial decidual reaction in postmenopausal breast cancer patients treated with tamoxifen and progestogens. Int J Gynecol Pathol 15:17–22PubMedCrossRefGoogle Scholar
  29. 29.
    Cohen I, Beyth Y, Shapira J et al (1997) High frequency of adenomyosis in postmenopausal breast cancer patients treated with tamoxifen. Gynecol Obstet Invest 44:200–205PubMedCrossRefGoogle Scholar
  30. 30.
    Colgan TJ, Shah R, Leyland N (1999) Post-hysteroscopic ablation reaction: A histopathologic study of electrosurgical ablation. Int J Gynecol Pathol 18:325–331PubMedCrossRefGoogle Scholar
  31. 31.
    Creagh TM, Bain BJ, Evans DJ et al (1995) Endometrial extramedullary haematopoiesis. J Pathol 176:99–104PubMedCrossRefGoogle Scholar
  32. 32.
    Critchley HO, Tong S, Cameron ST et al (1999) Regulation of bcl-2 gene family members in human endometrium by antiprogestin administration in vivo. J Reprod Fertil 115:389–395PubMedCrossRefGoogle Scholar
  33. 33.
    Crum CP, Hornstein MD, Nucci MR (2003) Hertig and beyond: a systematic and practical approach to the endometrial biopsy. Adv Anat Pathol 10:301–318PubMedCrossRefGoogle Scholar
  34. 34.
    Dal Cin P, De Wolf F, Klerckx P et al (1992) The 6p21 chromosome region is nonrandomly involved in endometrial polyps. Gynecol Oncol 46:393–396PubMedCrossRefGoogle Scholar
  35. 35.
    Delmas PD, Bjarnson NH, Mitlak BH et al (1997) Effects of raloxifene on bone mineral density, serum cholesterol concentrations, and uterine endometrium in postmenopausal women. N Eng J Med 337:1641–1647CrossRefGoogle Scholar
  36. 36.
    De Quintall MM, De Angelo Andrade LA (2006) Endometrial polyp with sex cord-like pattern. Int J Gynecol Pathol 25:170–172CrossRefGoogle Scholar
  37. 37.
    Disep B, Innes BA, Cochrane HR et al (2004) Immunohistochemical characterization of endometrial leucocytes in endometritis. Histopathology 45:625–632PubMedCrossRefGoogle Scholar
  38. 38.
    Duncan DA, Varner RE, Mazur MT (1989) Uterine herpes virus infection with multifocal necrotizing endometritis. Hum Pathol 20:1021–1024PubMedCrossRefGoogle Scholar
  39. 39.
    Dutra F (1959) Intraglandular morules of the endometrium. Am J Clin Pathol 31:60–65PubMedGoogle Scholar
  40. 40.
    The Writing Group for the PEPI Trial (1996) Effects of hormone replacement therapy on endometrial histology in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. JAMA 275:370–375CrossRefGoogle Scholar
  41. 41.
    Euscher E, Nuovo GJ (2002) Detection of kappa-and lamda-expressing cells in the endometrium by in-situ hybridisation. Int J Gynecol Pathol 21:383–390PubMedCrossRefGoogle Scholar
  42. 42.
    Fechner RE, Bossart MI, Spjut HJ (1979) Ultrastructure of endometrial stromal foam cells. Am J Clin Pathol 72:628–633PubMedGoogle Scholar
  43. 43.
    Feeley KM, Wells M (2001) Hormone replacement therapy and the endometrium. J Clin Pathol 54:435–440PubMedCrossRefGoogle Scholar
  44. 44.
    Ferryman SR, Stephens M, Gough D (1992) Necrotising granulomatous endometritis following endometrial ablation therapy. Br J Obstet Gynaecol 99:928–930PubMedCrossRefGoogle Scholar
  45. 45.
    Fisher B, Consantino JP, Wickerham DL et al (1998) Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst 90:1371–1388PubMedCrossRefGoogle Scholar
  46. 46.
    Fletcher JA, Pinkus GS, Donovan K et al (1992) Clonal rearrangement of chromosome band 6p21 in the mesenchymal component of pulmonary chondroid hamartoma. Cancer Res 52:6224–6228PubMedGoogle Scholar
  47. 47.
    Fluhmann CF (1960) The developmental anatomy of the cervix uteri. Obstet Gynaecol 15:62–69Google Scholar
  48. 48.
    Frank TS, Himebaugh KS, Wilson MD (1992) Granulomatous endometritis associated with histologically occult cytomegalovirus in a healthy patient. Am J Surg Pathol 16:716–720PubMedCrossRefGoogle Scholar
  49. 49.
    Genest DR, Brodsky G, Lage JA (1995) Localized endometrial proliferations associated with pregnancy: Clinical and histopathologic features of 11 cases. Hum Pathol 26:1233–1240PubMedCrossRefGoogle Scholar
  50. 50.
    Gilks CB, Clement PB, Hart WR et al (2000) Uterine adenomyomas excluding atypical polypoid adenomyomas and adenomyomas of endocervical type: a clinicopathologic study of 30 cases of an underemphasized lesion that may cause diagnostic problems with brief consideration of adenomyomas of other female genital tract sites. Int J Gynecol Pathol 19:195–205PubMedCrossRefGoogle Scholar
  51. 51.
    Gompel A, Sabourin JC, Martin A et al (1994) Bcl-2 expression in normal endometrium during the menstrual cycle. Am J Pathol 144:1195–1202PubMedGoogle Scholar
  52. 52.
    Gordon SJ, Westgate J (1999) The incidence and management of failed pipelle sampling in a general outpatient clinic. Aust N Z J Obstet Gynaecol 39:115–118PubMedCrossRefGoogle Scholar
  53. 53.
    Grady D, Gebrestsadik T, Kerlikowske K et al (1995) Hormone replacement therapy and endometrial cancer risk: a meta-analysis. Obstet Gynaecol 85:304–313CrossRefGoogle Scholar
  54. 54.
    Hachisuga T, Hideshima T, Kawarabayashi T et al (1999) Expression of steroid receptors, Ki-67 and epidermal growth factor receptor in tamoxifen-treated endometrium. Int J Gynecol Pathol 18:297–303PubMedCrossRefGoogle Scholar
  55. 55.
    Heatley MK (2006) Atypical polypoid adenomyoma: a systematic review of the English literature. Histopathology 48:609–610PubMedCrossRefGoogle Scholar
  56. 56.
    Hejmadi RK, Chaudhri S, Ganesan R, Rollason TP (2007) Morphologic changes in the endometrium associated with the use of the mirena coli: a retrospective study of 106 cases. Int J Surg Pathol 15:148–154PubMedCrossRefGoogle Scholar
  57. 57.
    Hendrickson MR, Kempson RL (1980) Endometrial epithelial metaplasias: proliferations frequently misdiagnosed as adenocarcinoma. Report of 89 cases and proposed classification. Am J Surg Pathol 4:525–542PubMedCrossRefGoogle Scholar
  58. 58.
    Hendrickson M, Ross J, Eifel P et al (1982) Uterine papillary serous carcinoma: a highly malignant form of endometrial adenocarcinoma. Am J Surg Pathol 6:93–108PubMedCrossRefGoogle Scholar
  59. 59.
    Herbold DR, Magrane DM (1986) Calcifications of the benign endometrium. Arch Pathol Lab Med 110:666–669PubMedGoogle Scholar
  60. 60.
    Houghton J, Ioffe O, Silverberg SG et al (2003) Metastatic breast lobular carcinoma involving tamoxifen-associated endometrial polyps: report of two cases and review of tamoxifen-associated polypoid uterine lesions. Mod Pathol 16:395–398PubMedCrossRefGoogle Scholar
  61. 61.
    Houghton JP, Roddy S, Carroll S, McCluggage WG (2004) A simple method for the prevention of endometrial autolysis in hysterectomy specimens. J Clin Pathol 57:332–333PubMedCrossRefGoogle Scholar
  62. 62.
    Houghton O, Connolly LE, McCluggage WG (2008) Morules in endometrioid proliferations of the uterus and ovary consistently express the intestinal transcription factor CDX2. Histopathology 53:156–165PubMedCrossRefGoogle Scholar
  63. 63.
    Huang KT, Chen CA, Cheng WF et al (1996) Sonographic characteristics of adenofibroma of the endometrium following tamoxifen therapy for breast cancer: two case reports. Ultrasound Obstet Gynecol 7:363–366PubMedCrossRefGoogle Scholar
  64. 64.
    Huettner PC, Gersell DJ (1994) Arias-Stella reaction in nonpregnant women: a clinicopathologic study of nine cases. Int J Gynecol Pathol 13:241–247PubMedCrossRefGoogle Scholar
  65. 65.
    Hui P, Kelly M, O’Malley DM et al (2005) Minimal uterine serous carcinoma: a clinicopathological study of 40 cases. Mod Pathol 18:75–82PubMedCrossRefGoogle Scholar
  66. 66.
    Iezzoni JC, Mills SE (2001) Nonneoplastic endometrial signet-ring cells. Vacuolated decidual cells and stromal histiocytes mimicking adenocarcinoma. Am J Clin Pathol 115:249–255PubMedCrossRefGoogle Scholar
  67. 67.
    Irving JA, McFarland D, Stuart DS et al (2000) Mitotic arrest of endometrial epithelium after paclitaxel therapy for breast cancer. Int J Gynecol Pathol 19:395–397PubMedCrossRefGoogle Scholar
  68. 68.
    Ismail SM (1994) Pathology of endometrium treated with tamoxifen. J Clin Pathol 47:827–833PubMedCrossRefGoogle Scholar
  69. 69.
    Ismail SM (1999) Gynaecological effects of tamoxifen. J Clin Pathol 52:83–88PubMedCrossRefGoogle Scholar
  70. 70.
    Kaufman RH, Binder GL, Gray PN et al (1977) Upper genital tract changes associated with exposure in utero to diethylstilbestrol. Am J Obstet Gynecol 128:51PubMedGoogle Scholar
  71. 71.
    Kelly P, Dobbs SP, McCluggage WG (2007) Endometrial hyperplasia involving endometrial polyps: report of a series and discussion of the significance in an endometrial biopsy specimen. Br J Obstet Gynaecol 114:944–950CrossRefGoogle Scholar
  72. 72.
    Kennedy MM, Baigrie CF, Manek S (1999) Tamoxifen and the endometrium: review of 102 cases and comparison with HRT-related and non-HRT-related endometrial pathology. Int J Gynecol Pathol 18:130–137PubMedCrossRefGoogle Scholar
  73. 73.
    Khatamee MA, Sommers SC (1989) Clinicopathologic diagnosis of mycoplasma endometritis. Int J Fertil 34:52–59PubMedGoogle Scholar
  74. 74.
    Kim KR, Lee YH, Ro JY (2002) Nodular histiocytic hyperplasia of the endometrium. Int J Gynecol Pathol 21:141–146PubMedCrossRefGoogle Scholar
  75. 75.
    Kurman RJ, Young RH, Norris HJ et al (1984) Immunocytochemical localization of placental lactogen and chorionic gonadotropin in the normal placenta and trophoblastic tumors, with emphasis on intermediate trophoblast and the placental site trophoblastic tissue. Int J Gynecol Pathol 3:101PubMedCrossRefGoogle Scholar
  76. 76.
    Lehman MB, Hart WR (2002) Simple and complex hyperplastic papillary proliferations of the endometrium: a clinicopathologic study of nine cases of apparently localized papillary lesions with fibrovascular stromal cores and epithelial metaplasia. Am J Surg Pathol 25:1347–1354CrossRefGoogle Scholar
  77. 77.
    Leung ASY, Vinyuvat S, Leong FJWM et al (1997) Anti-CD38 and VS38 antibodies for detection of plasma cells in the diagnosis of chronic endometritis. Appl Immunohistochem Mol Morphol 5:189–193CrossRefGoogle Scholar
  78. 78.
    Lindenman E, Shepard MK, Pescovitz OH (1997) Clinical commentary. Müllerian agenesis: an update Obstet Gynecol 90:307–312CrossRefGoogle Scholar
  79. 79.
    Longacre TA, Chung MH, Rouse RV et al (1996) Atypical polypoid adenomyofibromas (atypical polypoid adenomyomas) of the uterus. A clinicopathologic study of 55 cases. Am J Surg Pathol 20:1–20PubMedCrossRefGoogle Scholar
  80. 80.
    McCluggage WG, Roberts N, Bharucha H (1995) Enteric differentiation in endometrial adenocarcinomas: a mucin histochemical study. Int J Gynecol Pathol 14:250–254PubMedCrossRefGoogle Scholar
  81. 81.
    McCluggage WG, Varma V, Weir P, Bharucha H (1996) Uterine leiomyosarcoma in patient receiving tamoxifen therapy. Acta Obstet Gynecol Scand 75:593–595PubMedCrossRefGoogle Scholar
  82. 82.
    McCluggage WG, Ashe P, McBride H et al (1998) Localization of the cellular expression of inhibin in trophoblastic tissue. Histopathology 32:252–256PubMedCrossRefGoogle Scholar
  83. 83.
    McCluggage WG, Hamal P, Traub AI, Walsh MY (2000) Uterine adenolipoleiomyoma: a rare hamartomatous lesion. Int J Gynecol Pathol 19:183–185PubMedCrossRefGoogle Scholar
  84. 84.
    McCluggage WG, Abdulkader M, Price JH et al (2000) Uterine carcinosarcomas in patients receiving tamoxifen: a report of 19 cases. Int J Gynecol Cancer 10:280–284PubMedCrossRefGoogle Scholar
  85. 85.
    McCluggage WG, Desai V, Manek S (2000) Tamoxifen-associated postmenopausal adenomyosis exhibits stromal fibrosis, glandular dilatation and epithelial metaplasias. Histopathology 37:340–346PubMedCrossRefGoogle Scholar
  86. 86.
    McCluggage WG, Sumathi VP, Maxwell P (2001) CD10 is a sensitive and diagnostically useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms. Histopathology 39:273–278PubMedCrossRefGoogle Scholar
  87. 87.
    McCluggage WG (2002) Malignant biphasic uterine tumours: carcinosarcomas or metaplastic carcinomas? J Clin Pathol 55:321–325PubMedCrossRefGoogle Scholar
  88. 88.
    McCluggage WG (2003) Metaplasias in the female genital tract. In: Lowe D, Underwood J (eds) Recent Advances in Histopathology, vol 20. Royal Society of Medicine Press Ltd, LondonGoogle Scholar
  89. 89.
    McCluggage WG, Oliva E, Herrington CS et al (2003) CD10 and calretinin staining of endocervical glandular lesions, endocervical stroma and endometrioid adenocarcinomas of the uterine corpus: CD10 positivity is characteristic of, but not specific for, mesonephric lesions and is not specific for endometrial stroma. Histopathology 43:144–150PubMedCrossRefGoogle Scholar
  90. 90.
    McCluggage WG, Sumathi VP, McManus DT (2003) Uterine serous carcinoma and endometrial intraepithelial carcinoma arising in endometrial polyps: report of 5 cases, including 2 associated with tamoxifen therapy. Hum Pathol 34:939–943PubMedCrossRefGoogle Scholar
  91. 91.
    McCluggage WG (2006) My approach to the interpretation of endometrial biopsies and curettings. J Clin Pathol 59:801–812PubMedCrossRefGoogle Scholar
  92. 92.
    McCullough TA, Wagner B, Duffy S et al (1995) The pathology of hysterectomy specimens following transcervical resection of the endometrium. Histopathology 27:541–547CrossRefGoogle Scholar
  93. 93.
    McKenna M, McCluggage WG (2008) Signet ring cells of stromal derivation in the uterine cervix secondary to cauterization: report of a previously undescribed phenomenon. J Clin Pathol 61:648–651PubMedCrossRefGoogle Scholar
  94. 94.
    Machado F, Moreno J, Carazo M et al (2003) Accuracy of endometrial biopsy with the Cornier pipelle for diagnosis of endometrial cancer and atypical hyperplasia. Eur J Gynecol Oncol 24:279–281Google Scholar
  95. 95.
    Marchini M, Fedele L, Bianchi S et al (1992) Endometrial patterns during therapy with danazol or gestrinone for endometriosis- structural and ultrastructural study. Hum Pathol 23:51–56PubMedCrossRefGoogle Scholar
  96. 96.
    Marshall RJ, Jones DB (1988) An immunohistochemical study of lymphoid ADD in human endometrium. Int J Gynecol Pathol 7:225–235PubMedCrossRefGoogle Scholar
  97. 97.
    Mazur MT (1981) Atypical polypoid adenomyomas of the endometrium. Am J Surg Pathol 5:473–482PubMedCrossRefGoogle Scholar
  98. 98.
    Mazur MT, Hendrickson MR, Kempson RL (1983) Optically clear nuclei. An alteration of endometrial epithelium in the presence of trophoblast Am J Surg Pathol 7:415–423CrossRefGoogle Scholar
  99. 99.
    Miko TL, Lampe LG, Thomazy VA et al (1988) Eosinophilic endomyometritis associated with diagnostic curettage. Int J Gynecol Pathol 7:162–172PubMedCrossRefGoogle Scholar
  100. 100.
    Mittal K, Da Costa M (2008) Endometrial hyperplasia and carcinoma in endometrial polyps: clinicopathologic and follow-up findings. Int J Gynecol Pathol 27:45–48PubMedCrossRefGoogle Scholar
  101. 101.
    Morsi HM, Leers MP, Jager W et al (2000) The patterns of expression of an apoptosis-related CK18 neoepitope, the bcl-2 proto-oncogene, and the Ki67 proliferation marker in normal, hyperplastic, and malignant endometrium. Int J Gynecol Pathol 19:118–126PubMedCrossRefGoogle Scholar
  102. 102.
    Murray MJ, Meyer WR, Zaino RJ et al (2004) A critical analysis of the accuracy, reproducibility, and clinical utility of histologic endometrial dating in fertile women. Fertil Steril 81:1333–1343PubMedCrossRefGoogle Scholar
  103. 103.
    Mutter GL, Zaino RJ, Baak JPA et al (2007) Benign endometrial hyperplasia sequence and endometrial intraepithelial neoplasia. Int J Gynecol Pathol 26:103–114PubMedCrossRefGoogle Scholar
  104. 104.
    Mutter GL, Bergeron C, Deligdish L et al (2008) The spectrum of endometrial pathology induced by progesterone receptor modulators. Mod Pathol 21:591–598PubMedCrossRefGoogle Scholar
  105. 105.
    Nand SL, Webster MA, Baber R et al (1998) Bleeding pattern and endometrial changes during continuous combined hormone replacement therapy. Obstet Gynecol 91:678–684PubMedCrossRefGoogle Scholar
  106. 106.
    Nakamura Y, Moritsuka Y, Ohta Y et al (1989) S-100 protein in glands within decidua and cervical glands during early pregnancy. Hum Pathol 20:1204–1209PubMedCrossRefGoogle Scholar
  107. 107.
    Noyes FW, Hertig AT, Rock J (1950) Dating the endometrial biopsy. Fertil Steril 1:3–25Google Scholar
  108. 108.
    Nucci MR, Prasad CJ, Crum CP, Mutter GL (1999) Mucinous endometrial epithelial proliferations: A morphologic spectrum of changes with diverse clinical significance. Mod Pathol 12:1137–1142PubMedGoogle Scholar
  109. 109.
    Nucci MR, Young RH (2004) Arias-Stella reaction of the endocervix: a report of 18 cases with emphasis on its varied histology and differential diagnosis. Am J Surg Pathol 2004(28):608–612CrossRefGoogle Scholar
  110. 110.
    O’Brien PK, Roth-Moyo LA, Davis BA (1981) Pseudo-sulfur granules associated with intrauterine contraceptive devices. Am J Clin Pathol 75:822–825PubMedGoogle Scholar
  111. 111.
    O’Connell JT, Mutter GL, Cviko A et al (2001) Identification of a basal/reserve cell immunophenotype in benign and neoplastic endometrium: a study with the p53 homologue p63. Gynecol Oncol 80:30–36PubMedCrossRefGoogle Scholar
  112. 112.
    O’Connor DM, Kurman RJ (1988) Intermediate trophoblast in uterine curettings in the diagnosis of ectopic pregnancy. Obstet Gynecol 72:665–670PubMedGoogle Scholar
  113. 113.
    Ohishi Y, Kaku T, Kobayashi H et al (2008) CD10 immunostaining distinguishes atypical polypoid adenomyofibroma (atypical polypoid adenomyoma) from endometrial carcinoma invading the myometrium. Hum Pathol 39:1446–1453PubMedCrossRefGoogle Scholar
  114. 114.
    Ota S, Catasus L, Matias-Guiu X et al (2003) Molecular pathology of atypical polypoid adenomyoma of the uterus. Hum Pathol 34:784–788PubMedCrossRefGoogle Scholar
  115. 115.
    Paavonen J, Aine R, Teisala K et al (1985) Chlamydial endometritis. J Clin Pathol 38:726–732PubMedCrossRefGoogle Scholar
  116. 116.
    Paganini-Hill A, Ross RK, Henderson BE (1989) Endometrial cancer and patterns of oestrogen replacement therapy. Cancer 59:445–447CrossRefGoogle Scholar
  117. 117.
    Pearce KF, Nolan TA (1996) Endometrial sarcoidosis as a cause of postmenopausal bleeding. J Reprod Med 41:878–888PubMedGoogle Scholar
  118. 118.
    Perkins MB (1960) Pneumopolycystic endometritis. Am J Obstet Gynecol 80:332–336PubMedGoogle Scholar
  119. 119.
    Phillips V, Graham CT, Manek S, McCluggage WG (2003) The effects of the levonorgestrel intrauterine system (Mirena coil) on endometrial morphology. J Clin Pathol 56:305–307PubMedCrossRefGoogle Scholar
  120. 120.
    Phillips VP, McCluggage WG (2005) Results of a questionnaire regarding criteria for adequacy of endometrial biopsies. J Clin Pathol 58:417–419PubMedCrossRefGoogle Scholar
  121. 121.
    Pins MR, Young RH, Crum CP et al (1997) Cervical squamous cell carcinoma in situ with intraepithelial extension to the upper genital tract and invasion of tubes and ovaries: report of a case with human papillomavirus analysis. Int J Gynecol Pathol 16:272–278PubMedCrossRefGoogle Scholar
  122. 122.
    Pritt B, Mount SL, Cooper K, Blaszyk H (2006) Pseudoactinomycotic radiate granules of the gynaecological tract: review of a diagnostic pitfall. J Clin Pathol 59:17–20PubMedCrossRefGoogle Scholar
  123. 123.
    Quddus MR, Sung CJ, Zheng W, Lauchlan SC (1999) p53 immunoreactivity in endometrial metaplasia with dysfunctional uterine bleeding. Histopathology 35:44–49PubMedCrossRefGoogle Scholar
  124. 124.
    Saegusa M, Okayasu I (2001) Frequent nuclear beta-catenin accumulation and associated mutations in endometrioid-type endometrial and ovarian carcinomas with squamous differentiation. J Pathol 194:59–67PubMedCrossRefGoogle Scholar
  125. 125.
    Sahin AA, Silva EG, Landon G et al (1989) Endometrial tissue in myometrial vessels not associated with menstruation. Int J Gynecol Pathol 8:139–146PubMedCrossRefGoogle Scholar
  126. 126.
    Schindler AE, Schmidt G (1980) Postmenopausal bleeding: A study of more than 1000 cases. Maturitas 2:269–274PubMedCrossRefGoogle Scholar
  127. 127.
    Schlesinger C, Kamoi S, Ascher SM et al (1998) Endometrial polyps: a comparison study of patients receiving tamoxifen with two control groups. Int J Gynecol Pathol 17:302–311PubMedCrossRefGoogle Scholar
  128. 128.
    Scott M, Lyness RW, McCluggage WG (2006) Atypical reactive proliferation of endocervix: a common lesion associated with endometrial carcinoma and likely related to prior endometrial sampling. Mod Pathol 19:470–474PubMedCrossRefGoogle Scholar
  129. 129.
    Scurry J, Planner R, Fortune DW, Lee CS, Rode J (1993) Ligneous (pseudomembranous) inflammation of the female genital tract: a report of two cases. J Reprod Med 38:407–412PubMedGoogle Scholar
  130. 130.
    Seidman JD, Kurman RJ (1999) Tamoxifen and the endometrium. Int J Gynecol Pathol 18:293–296PubMedCrossRefGoogle Scholar
  131. 131.
    Shah SS, Mazur MT (2008) Endometrial eosinophilic syncytial change related to breakdown: immunohistochemical evidence suggests a regressive process. Int J Gynecol Pathol 27:534–538PubMedCrossRefGoogle Scholar
  132. 132.
    Shapiro S, Kelly JP, Rosenberg L et al (1985) Risk of localized and widespread endometrial cancer in relation to recent and discontinued use of conjugated estrogens. New Eng J Med 313:969–972PubMedCrossRefGoogle Scholar
  133. 133.
    Shibutani S, Ravindernath A, Suzuki N et al (2000) Identification of tamoxifen-DNA adducts in the endometrium of women treated with tamoxifen. Carcinogenesis 21:1461–1467PubMedCrossRefGoogle Scholar
  134. 134.
    Silva EG, Jenkins R (1990) Serous carcinoma in endometrial polyps. Mod Pathol 3:120–128PubMedGoogle Scholar
  135. 135.
    Soslow RA, Chung MH, Rouse RV et al (1996) Atypical polypoid adenomyofibroma (APA) versus well-differentiated endometrial carcinoma with prominent stromal matrix: an immunohistochemical study. Int J Gynecol Pathol 15:209–216PubMedCrossRefGoogle Scholar
  136. 136.
    Staland B (1981) Continuous treatment with natural oestrogens and progestagens. A method to avoid endometrial stimulation. Maturitas 3:145–156PubMedCrossRefGoogle Scholar
  137. 137.
    Stasny JF, Ben-Ezra J, Stewart JA et al (1995) Condyloma and cervical intraepithelial neoplasia of the endometrium. Gynecol Obstet Invest 39:277–280CrossRefGoogle Scholar
  138. 138.
    Stewart CJR, Michie BA, Kennedy JH (1998) Focal endometrial stromal hyperplasia. Histopathology 33:75–79PubMedCrossRefGoogle Scholar
  139. 139.
    Stewart CJ, Campbell-Brown M, Critchley HO, Farqharson MA (1999) Endometrial apoptosis in patients with dysfunctional uterine bleeding. Histopathology 34:99–105PubMedCrossRefGoogle Scholar
  140. 140.
    Sturdee DW, Ulrich LG, Barlow DH et al (2000) The endometrial response to sequential and continuous combined oestrogen-progestogen replacement therapy. Br J Obstet Gynaecol 107:1392–1400CrossRefGoogle Scholar
  141. 141.
    Tabibzadeh S, Kong Q, Satyaswaroop P et al (1994) Distinct regional and menstrual cycle dependent distribution of apoptosis in human endometrium. Potential regulatory role of T cells and TNF-alpha. Endocrinol J 2:87–95Google Scholar
  142. 142.
    Tahlan A, Nanda A, Mohan H (2006) Uterine adenomyoma: a clinicopathologic review of 26 cases and a review of the literature. Int J Gynecol Pathol 25:361–365PubMedCrossRefGoogle Scholar
  143. 143.
    Tai LH, Tavassoli FA (2002) Endometrial polyps with atypical (bizarre) stromal cells. Am J Surg Pathol 26:505–509PubMedCrossRefGoogle Scholar
  144. 144.
    Taketani Y, Masahiko M (1991) Evidence for direct regulation of epidermal growth factor receptors by steroid hormones in human endometrial cells. Human Reprod 6:1365–1369Google Scholar
  145. 145.
    Thomas W Jr, Sadeghieh B, Fresco R et al (1978) Malacoplakia of the endometrium, a probable cause of postmenopausal bleeding. Am J Clin Pathol 69:637–641PubMedGoogle Scholar
  146. 146.
    Truskinovsky AM, Gerscoich EO, Duffield CR, Vogt PJ (2008) Endometrial microcalcifications detected by ultrasonography: clinical associations, histopathology and potential etiology. Int J Gynecol Pathol 27:61–67PubMedCrossRefGoogle Scholar
  147. 147.
    Turbiner J, Moreno-Bueno G, Dahiya S et al (2008) Clinicopathological and molecular analysis of endometrial carcinoma associated with tamoxifen. Mod Pathol 21:925–936PubMedCrossRefGoogle Scholar
  148. 148.
    Usubutun A, Karamn N, Ayhan A et al (2005) Atypical endometrial stromal cells related with a polypoid leiomyoma with bizarre nuclei: a case report. Int J Gynecol Pathol 24:352–354PubMedCrossRefGoogle Scholar
  149. 149.
    Val-Bernal JF, Villoria F, Cagigal ML et al (2006) Pneumopolycstic endometritis. Am J Surg Pathol 30:258–261PubMedCrossRefGoogle Scholar
  150. 150.
    Vang R, Tavassoli FA (2003) Proliferative mucinous lesions of the endometrium: Analysis of existing criteria for diagnosing carcinoma in biopsies and curettings. Int J Surg Pathol 11:261–270PubMedCrossRefGoogle Scholar
  151. 151.
    Venkatraman L, Elliott H, Steele EK et al (2003) Serous adenocarcinoma arising in an adenofibroma of the endometrium. Int J Gynecol Pathol 22:194–197PubMedCrossRefGoogle Scholar
  152. 152.
    Wani Y, Notohara K, Saegusa M et al (2008) Aberrant Cdx2 expression in endometrial lesions with squamous differentiation: important role of Cdx2 in squamous morula formation. Mod Pathol 39:1072–1079Google Scholar
  153. 153.
    Wells M, Tiltman A (1989) Intestinal metaplasia of the endometrium. Histopathology 15:431–433PubMedCrossRefGoogle Scholar
  154. 154.
    Wheeler DT, Bristow RE, Kurman RJ (2007) Histologic alterations in endometrial hyperplasia and well-differentiated carcinoma treated with progestins. Am J Surg Pathol 31:988–998PubMedCrossRefGoogle Scholar
  155. 155.
    Winkler B, Reumann W, Mitao M et al (1984) Chlamydia endometritis: a histological and immunohistochemical analysis. Am J Surg Pathol 8:771–778PubMedCrossRefGoogle Scholar
  156. 156.
    Winter JD, Kohn G, Mellinin WJ et al (1968) A familial syndrome of renal, genital, and middle ear anomalies. J Pediatr 72:88PubMedCrossRefGoogle Scholar
  157. 157.
    Yokomyama S, Kashima K, Inoue S et al (1993) Biotin-containing intranuclear inclusions in endometrial glands during gestation and puerperium. Am J Clin Pathol 99:13–17Google Scholar
  158. 158.
    Young RH, Harris NL, Scully RE (1985) Lymphoma-like lesions of the lower female genital tract: a report of 16 cases. Int J Gynecol Pathol 4:289–299PubMedCrossRefGoogle Scholar
  159. 159.
    Young RH, Treger T, Scully RE (1986) Atypical polypoid adenomyoma of the uterus: a report of 27 cases. Am J Clin Pathol 86:139–145PubMedGoogle Scholar
  160. 160.
    Zaloudek CJ, Norris HJ (1991) Adenofibroma and adenosarcoma of the uterus: a clinicopathologic study of 35 cases. Cancer 48:354–366CrossRefGoogle Scholar

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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of PathologyRoyal Group of Hospitals TrustBelfastNorthern Ireland

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