Abstract
The placenta is crucial for fetal growth and survival, performing the most important functions of many somatic organs before birth. Thus, pathologic processes interfering with placental function may result in abnormalities of fetal growth or development, malformation, or stillbirth, and there is increasing recognition that some long-term (especially neurologic) disabilities can be traced to injury occurring before birth. The purpose of this chapter is to describe clinically important placental lesions and to emphasize the context in which these lesions are directly or indirectly important to the fetus, the mother, or both.
References
Abramowsky C, Beyer-Patterson P et al (1991) Nonsyphilitic spirochetosis in second-trimester fetuses. Pediatr Pathol 11:827–838
Adams-Chapman I, Vaucher YE et al (2002) Maternal floor infarction of the placenta: association with central nervous system injury and adverse neurodevelopmental outcome. J Perinatol 22:236–241
Al-Adnani M, Kiho L et al (2008) Recurrent massive perivillous fibrin deposition associated with polymyositis: a case report and review of the literature. Pediatr Dev Pathol 11:226–229
Altshuler G (1984) Chorangiosis. An important placental sign of neonatal morbidity and mortality. Arch Pathol Lab Med 108:71–74
Altshuler G, Hyde S (1989) Meconium-induced vasocontraction: a potential cause of cerebral and other fetal hypoperfusion and of poor pregnancy outcome. J Child Neurol 4:137–142
Ananth CV, Oyelese Y et al (2005) Placental abruption in the United States, 1979 through 2001: temporal trends and potential determinants. Am J Obstet Gynecol 192:191–198
Ananth CV, Vintzileos AM et al (1998) Standards of birth weight in twin gestations stratified by placental chorionicity. Obstet Gynecol 91:917–924
Arias F, Rodriguez L et al (1993) Maternal placental vasculopathy and infection: two distinct subgroups among patients with preterm labor and preterm ruptured membranes. Am J Obstet Gynecol 168:585–591
Arias F, Romero R et al (1998) Thrombophilia: A mechanism of disease in women with adverse pregnancy outcome and thrombotic lesions in the placenta. J Matern Fetal Med 7:277–286
Ariel IB, Anteby E et al (2004) Placental pathology in fetal thrombophilia. Hum Pathol 35:729–733
Badawi N, Felix JF et al (2005) Cerebral palsy following term newborn encephalopathy. Devel Med Child Neurol 47:293–298
Baergen RN (2007) Cord abnormalities, structural lesions, and cord accidents. Semin Diag Pathol 24:23–32
Baergen RN, Malicki D et al (2001) Morbidity. mortality, and placental pathology in excessively long umbilical cords; retrospective study. Pediatr Devel Pathol 4:144–153
Baldwin VJ (1994) Pathology of multiple pregnancy. Springer, New York
Barth WH Jr, Genest DR et al (1996) Uterine arcuate artery Doppler and decidual microvascular pathology in pregnancies complicated by type I diabetes mellitus. Ultrasound Obstet Gynecol 8:98–103
Baschat AA, Gungor S et al (2007) Nucleated red blood cell counts in the first week of life: a critical appraisal of relationships with perinatal outcome in preterm growth restricted neonates. Am J Obstet Gynecol 197(3):286.e1–286.e8
Benirschke K, Kaufmann P et al (2006) Pathology of the human placenta, 5th edn. Springer, New York
Benirschke K, Masliah E (2001) The placenta in multiple pregnancy: outstanding issues. Reprod Fertil Dev 13(7–8):615–622
Berg TG, Rayburn WF (1995) Umbilical cord length and acid-base balance at delivery. J Reprod Med 40:1–12
Bieber FR, Nance WE et al (1981) Genetic studies of an acardiac monster: evidence of polar body twinning in man. Science 213:775–777
Blanc WA (1959) Amnionic infection syndrome. Pathogenesis, morphology, and significance in circumnatal mortality. Clin Obstet Gynaecol 2:705–734
Bloomfield RD, Suarez JR et al (1978) The placenta: a diagnostic tool in sickle cell disorders. J Natl Med Assoc 70:87–88
Boyd JD, Hamilton WJ (1970) The human placenta. Heffer, Cambridge
Bruner JP, Anderson TL et al (1998) Placental pathophysiology of the twin: oligohydramnios-polyhydramnios sequence and the twin-twin transfusion syndrome. Placenta 19:81–86
Burke CJ, Tannenberg AE (1995) Prenatal brain damage and placental infarction-An autopsy study. Devel Med Child Neurol 37:555–562
Chan OT, Mannino FL et al (2007) A retrospective analysis of placentas from twin pregnancies derived from assisted reproductive technology. Twin Res Hum Genet 10(2):385–393
Cleary GM, Wiswell TE (1998) Meconium-stained amnionic fluid and the meconium aspiration syndrome. An update. Pediatr Clin North Amer 45:511–529
Cooperstock MS, Tummara R et al (2000) Twin birth weight discordance and risk of preterm birth. Am J Obstet Gynecol 183:63–67
Curtin WM, Shehata BM et al (2002) The feasibility of using histologic placental sections to predict newborn nucleated red blood cell counts. Obstet Gynecol 110:305–310
Dahms B, Boyd T et al (2002) Severe perinatal liver disease associated with fetal thrombotic vasculopathy in the placenta. Pediatr Devel Pathol 5:80–85
Davis BH, Olsen S et al (1998) Detection of fetal red cells in fetomaternal hemorrhage using a fetal hemoglobin monoclonal antibody by flow cytometry. Transfusion 38:749–756
De Laat MWM, van Alderen ED et al (2007) The umbilical coiling index in complicated pregnancy. Eur J Obstet Gynecol Reprod Biol 130:66–72
Deans A, Jauniaux E (1998) Prenatal diagnosis and outcome of subamniotic hematomas. Ultrasound Obstet Gynecol 11:319–323
Decastel M, Leborgne-Samuel Y (1999) Morphological features of the human umbilical vein in normal, sickle cell trait, and sickle cell disease pregnancies. Hum Pathol 30(1):13–20
DeSa DJ (1973) Intimal cushions of foetal placental veins. J Pathol 110:347–352
Di Naro E, Ghezzi F et al (2001) Umbilical vein blood flow in fetuses with normal and lean umbilical cord. Ultrasound Obstet Gynecol 17:224–228
Dizon-Townson DS, Meline L et al (1997) Fetal carriers of the factor V Leiden mutation are prone to miscarriage and placental infarction. Am J Obstet Gynecol 177:402–405
Doss BJ, Jacques SM et al (1998) Maternal scleroderma: placenta findings and perinatal outcome. Hum Pathol 28:1524–1530
Dr G, Singer DB (1992) Estimating the time of death in stillborn fetuses: III. External fetal examination; a study of 86 stillborns. Obstet Gynecol 80:593–600
Esplin MS (2006) Preterm birth: a review of genetic factors and future directions for genetic study. Obstet Gynecol Survey 61:800–806
Fernandes BJ, von Dadelszen P et al (2007) Flow cytometric assessment of feto-maternal hemorrhage; a comparison with Bettke-Kleihauer. Prenat Diagn 27:641–643
Fok RY, Pavlova Z et al (1990) The correlation of arterial lesions with umbilical artery Doppler velocimetry in the placentas of small-for-dates pregnancies. Obstet Gynecol 75:578–583
Fox H (1966) Thrombosis of the foetal stem arteries in the human placenta. J Obstet Gynaecol Br Commonwealth 73:961–965
Fox H (1997) Pathology of the placenta, 2nd edn. Saunders, Philadelphia
Fox H, Sebire NJ (2007) Pathology of the placenta, 3rd edn. Saunders, Philadelphia
Frank HG, Malekzadeh F et al (1994) Immunohistochemistry of two different types of placental fibrinoid. Acta Anat 150:55–68
Fraser RB, Wright JR (2002) Eosinophilic/T-cell chorionic vasculitis. Pedatri Dev Pathol 5:350–355
Gardella C, Riley DE et al (2004) Identification and sequencing of bacterial rDNAs in culture-negative amniotic fluid from women in premature labor. Am J Perinatol 21:319–323
Gardiner JP (1922) The umbilical cord: normal length; length in cord complications; etiology and frequency of coiling. Surg Gynecol Obstet 34:252–256
Genest DR (1992) Estimating the time of death in stillborn fetuses: II. Histologic evaluation of the placenta; a study of 71 stillborns. Obstet Gynecol 80:585–592
Genest DR, Williams MA et al (1992) Estimating the time of death in stillborn fetuses: I. Histologic evaluation of fetal organs; an autopsy study of 150 stillborns. Obstet Gynecol 80:575–584
Ghidini A, Spong CY (2001) Severe meconium aspiration syndrome is not caused by aspiration of meconium. Am J Obstet Gynecol 185:931–938
Giles WB, Trudinger BJ et al (1985) Fetal umbilical artery flow velocity waveforms and placental resistance: pathological correlation. Brit J Obstet Gynaecol 92:31–38
Gomez R, Romero R et al (1998) The fetal inflammatory response syndrome. Am J Obstet Gynecol 179:194–202
Greer IA (1999) Thrombosis in pregnancy: maternal and fetal issues. Lancet 353:1258–1265
Gupta N, Sebire NJ et al (2004) Massive perivillous fibrin deposition associated with discordant fetal growth in a dichorionic twin pregnancy. J Obstet Gynaecol 24:579–580
Han YW, Redline RW et al (2004) Fusobacterium nucleatum induces premature and term stillbirths in pregnant mice: implication of oral bacteria in preterm birth. Infect Immun 72:2272–2279
Hansen AR, Collins MH et al (2000) Very low birthweight infant's placenta and its relation to pregnancy and fetal characteristics. Pediatr Devel Pathol 3:419–430
Hansen AR, Collins MH et al (2000) Very low birthweight placenta; clustering of morphologic characteristics. Pediatr Devel Pathol 3:431–438
Hashimoto K, Clapp JF (2003) The effect of nuchal cord on amniotic fluid and cord blood erythropoetin at delivery. J Soc Gynecol Investig 10:406–411
Hecht JL, Allred EN et al (2008) Histologic characteristics of singleton placentas delivered before the 28th week of gestation. Pathology 40:372–376
Heller DS, Rush D et al (2003) Subchorionic hematoma associated with thrombophilia: report of three cases. Pediatr Dev Pathol 6:261–264
Hermansen MC (2001) Nucleated red blood cells in the fetus and newborn. Arch Dis Child Fetal Neonatal Ed 84:F211–F215
Hershkovitz R, Silberstein T et al (2001) Risk factors associated with true knots of the umbilical cord. Eur J Obstet Gyneco Biol 93:36–39
Hill GB (1998) Preterm birth: associations with genital and possibly oral microflora. Ann Periodontal 3:222–232
Hung NA, Jackson C et al (2005) Pregnancy-related polymyositis and massive perivillous fibrin deposition in the placenta: are they pathogenetically related? Arthr Rhematism 55:154–156
Huppertz B, Kadyrov M et al (2006) Apoptosis and its role in the trophoblast. Am J Obstet Gynecol 195:29–39
Ibdah JA, Bennett MJ et al (1999) A fetal fatty acid oxidation disorder as a cause of liver disease in pregnant women. N Engl J Med 340:1723–1731
Jacques SM, Qureshi F (1998) Chronic chorioamnionitis: a clinicopathologic and immunohistochemical study. Hum Pathol 29:1457–1461
Jamshed S, Kouides P et al (2007) Pathology of thrombotic thrombocytopenic purpura in the placenta, with emphasis on the “snowman sign.”. Pediatr Dev Pathol 10:455–462
Jauniaux E, Nicolaides KH et al (1997) Perinatal features associated with placental mesenchymal dysplasia. Placenta 18:701–706
Kalousek DK, Bamforth S (1988) Amnion rupture sequence in previable fetuses. Am J Med Genet 31:63–73
Kalousek DK, Barrett I (1994) Confined placental mosaicism and stillbirth. Pediatr Pathol 14:151–159
Kalousek DK, Fitch N et al (1990) Pathology of the human embryo and previable fetus. An atlas. Springer, New York
Kaplan C, Blanc WA et al (1982) Identification of erythrocytes in intervillous thrombi. A study using immunoperoxidase identification of hemoglobins. Hum Pathol 13:554–557
Katz VL, DiTomasso J et al (2002) Activated protein C resistance associated with maternal floor infarction treated with low-molecular-weight heparin. Am J Perinatol 19:273–277
Katzman PJ, Genest DR (2002) Maternal floor infarction and massive perivillous fibrin deposition: histological definitions, association with intrauterine fetal growth restriction, and risk of recurrence. Pediatr Devel Pathol 5:159–164
Keenan WJ, Steichen JJ et al (1977) Placental pathology compared with clinical outcome. Am J Dis Child 131:1224–1227
Keogh JM, Badawi N (2006) The origins of cerebral palsy. Curr Opin Neurol 19:129–134
Khong TY (1999) The placenta in maternal hyperhomocysteinaemia. Br J Obstet Gynaecol 106:2733–2738
Kim CJ, Yoon BH et al (2001) Umbilical arteritis and phlebitis mark different stages of the fetal inflammatory response. Am J Obstet Gynecol 185(2):496–500
King EL, Redline RW et al (2004) Myocytes of chorionic vessels from placentas with meconium-associated vascular necrosis exhibit apoptotic markers. Hum Pathol 35(4):412–417
Kraus FT, Acheen VI (1999) Fetal thrombotic vasculopathy in the placenta: cerebral thrombi and infarcts, coagulopathies, and cerebral palsy. Hum Pathol 30:759–769
Kraus FT, Redline RW et al (2004) Placental pathology. ARP/AFIP, Washington DC
Kumar D, Fung W et al (2006) Proinflammatory cytokines found in amniotic fluid induce collagen remodeling, apoptosis, and biophysical weakening of cultured human fetal membranes. Biol Report 74(1):29–34
Lash GB, Quenby S et al (2008) Gestational diseases – a workshop report. Placenta 22:S92–S94
Leistra-Leistra MJ, Timmer A et al (2004) Fetal thrombotic vasculopathy in the placenta: a thrombophilic connection between pregnancy complications and neonatal thrombosis? Placenta 25(Suppl A):S102–S105
Leviton A, Paneth N et al (1999) Maternal infection, fetal inflammatory response, and brain damage in very low birth weight infants. Developmental Epidemiology Network Investigators. Pediatr Res 46(5):566–575
Lim FT, Scherjon SA et al (2000) Association of stress during delivery with increased numbers of nucleated cells and hematologic progenitor cells in umbilical cord blood. Am J Obstet Gynecol 183:1144–1151
Lim LK, Zhou Y et al (1997) Human cytotrophoblast differentiation/invasion is abnormal in pre-eclampsia. Am J Pathol 151:1809–1818
Lin MG (2006) Umbilical cord prolapse. Obstet Gynecol Surv 61(4):269–277
Machin GA, Ackerman J et al (2000) Abnormal umbilical cord coiling is associated with adverse perinatal outcomes. Pediatr Devel Pathol 3:462–471
Magid MS, Kaplan C et al (1998) Placental pathology in systemic lupus erythematosus: a prospective study. Am J Obstet Gynecol 179:226–236
Many A, Elad R et al (2002) Third trimester unexplained intrauterine fetal death is associated with inherited thrombophilia. Obstet Gynecol 99:684–687
Many A, Schreiber L et al (2001) Pathologic features of the placenta in women with severe pregnancy complications and thrombophilia. Obstet Gynecol 98:1041–1044
Matern D, Shehata BM et al (2001) Placental floor infarction complicating the pregnancy of a fetus with long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency. Mol Genet Metab 72:265–268
McDonald DG, Kelehan P et al (2004) Placental fetal thrombotic vasculopathy is associated with neonatal encephalopathy. Hum Pathol 35:875–880
Menezo YJ, Sakkas D (2002) Monozygotic twining: is it related to apoptosis in the embryo? Hum Reprod 17:247–248
Miller PW, Coen RW et al (1985) Dating the time interval from meconium passage to birth. Obstet Gynecol 66:459–462
Mitra SC, Seshan SV et al (2000) Placental vessel morphometry in growth retardation and increased resistance of the umbilical artery Doppler flow. J Matern Fetal Med 9:282–286
Moscoso G, Jauniaux E et al (1991) Placental vascular anomaly with diffuse mesenchymal stem villous hyperplasia. A new clinico-pathological entity? Path Res Pract 187:324–328
Mutter WP, Karumanchi SA (2008) Molecular mechanisms of preeclampsia. Microvasc Res 75:1–8
Myerson D, Parkin RK (2006) The pathogenesis of villitis of unknown etiology: analysis with a new conjoint immunohistochemistry-in situ hybridization procedure to identify specific maternal and fetal cells. Pediatr Dev Pathol 9(4):257–265
Naeye RL (1985) Umbilical cord length: clinical significance. J Pediatr 107:278–281
Naeye RL, Maisels J et al (1983) The clinical significance of placental villous edema. Pediatrics 71:588–594
Naeye RL, Shaffer ML (2005) Postnatal laboratory timers of antenatal hypoxic-ischemic brain damage. J Perinatol 25:664–668
Nelson KB, Dambrosia JM et al (1998) Neonatal cytokines and coagulation factors in children with cerebral palsy. Ann Neurol 44:665–675
Nelson KB, Dambrosia JM et al (2005) Genetic polymorphisms and cerebral palsy in very preterm infants. Pediatr Res 57:494–499
Nelson KB, Grether KJ (1998) Potentially asphyxiating conditions and spastic cerebral palsy in infants of normal birth weight. Am J Obstet Gynecol 179:507–513
Ogino S, Redline RW (2000) Villous capillary lesions of the placenta: Distinctions between chorangioma, chorangiomatosis, and chorangiosis. Hum Pathol 31:945–954
Ohyama M, Itani Y et al (2002) Re-evaluation of chorioamnionitis and funisitis with a special reference to subacute chorioamnionitis. Hum Pathol 33:183–190
Ordi J, Ismail MR et al (1998) Massive chronic intervillositis of the placenta associated with malaria infection. Am J Surg Pathol 22:1006–1011
Parast MM, Crum CP et al (2008) Placental histological criteria for umbilical flow restriction in unexplained stillbirth. Hum Pathol 39:948–953
Patel D, Dawson M et al (1989) Umbilical cord circumference at birth. Am J Dis Child 143:638–639
Peng HW, Levitin-Smith M et al (2006) Umbilical cord stricture and overcoiling are common causes of fetal demise. Pediatr Dev Pathol 9:14–19
Pham T, Steele J et al (2006) Placental mesenchymal dysplasia is associated with high rates of intrauterine growth restriction and fetal demise. A report of 11 new cases and review of the literature. AOLP 126:67–78
Pharaoh P, Adi Y (2000) Consequences of in-utero death in twin pregnancy. Lancet 355:1597–1602
Phelan JP, Korst LM et al (1998) Neonatal nucleated red blood cell and lymphocyte counts in fetal brain injury. Obstet Gynecol 91:485–489
Qureshi F, Jacques SM (1994) Marked segmental thinning of the umbilical cord vessels. Arch Pathol Lab Med 118:826–830
Raio L, Ghezzi F (1998) The clinical significance of antenatal detection of discordant umbilical arteries. Obstet Gynecol 91:86–91
Raio L, Ghezzi F et al (1999) Prenatal diagnosis of a lean umbilical cord: A simple marker for the fetus at risk of being small for gestational age at birth. Ultrasound Obstet Gynecol 13:176–180
Rakheja D, Bennett MJ et al (2002) Long-chain L-3-hydroxyacyl-coenzyme A dehydrogenase deficiency: a molecular and biochemical review. Lab Invest 82:815–824
Rand JH (2000) Antiphospholipid antibody-mediated disruption of the annexin-V antithrombotic shield: a thrombogenic mechanism for the antiphospholipid syndrome. J Autoimmun 15:107–111
Rayne SC, Kraus FT (1993) Placental thrombi and other vascular lesions. Classification, morphology, and clinical correlations. Pathol Res Pract 189:2–17
Redline RW (1988) Role of local immunosuppression in murine fetoplacental listeriosis. J Clin Invest 79:1234–1241
Redline RW (1988) Specific defects in the anti-listerial immune response in discrete regions of the murine uterus and placenta account for susceptibility to infection. J Immunol 140:3947–3955
Redline RW (2002) Clinically and biologically relevant patterns of placental inflammation. Pediatr Dev Pathol 5:326–328
Redline RW (2004) Clinical and pathological umbilical cord abnormalities in fetal thrombotic vasculopathy. Hum Pathol 35:1494–1498
Redline RW (2004) Placental inflammation. Seminars Neonat 9:265–274
Redline RW (2005) Severe fetal placental vascular lesions in term infants with neurologic impairment. Am J Obstet Gynecol 192:452–457
Redline RW (2006) Inflammatory responses in the placenta and umbilical cord. Sem Fetal and Neonat Med 11:296–301
Redline RW (2006) Thrombophilia and placental pathology. Clin Obstet and Gynecol 49(4):885–894
Redline RW (2006) Placental pathology and cerebral palsy. Clin Perinat 33:503–516
Redline RW (2007) Infections and other inflammatory conditions. Sem Diag Pathol 24:5–13
Redline RW (2007) Villitis of unknown etiology: noninfectious chronic villitis in the placenta. Hum Pathol 38(10):1439–1446
Redline RW (2008) Placental pathology: a systematic approach with clinical correlations. Placenta 29:S86–S89
Redline RW (2008) Elevated circulating fetal nucleated red blood cells and placental pathology in term infants who develop cerebral palsy. Hum Pathol 39:1378–1384
Redline RW, Ariel IB et al (2004) Fetal vascular obstructive lesions: Nosology and reproducibility of placental reaction patterns. Pediatr Devel Pathol 7:443–452
Redline RW, Boyd T et al (2004) Maternal vascular underperfusion: nosology and reproducibility of placental reaction patterns. Pediatr Devel Pathol 7:237–249
Redline RW, Dinesh S et al (2001) Placental lesions associated with abnormal growth in twins. Pediatr Dev Pathol 4:473–481
Redline RW, Faye-Petersen O et al (2003) Amniotic infection syndrome: nosology and reproducibility of placental reaction patterns. Pediatr Dev Pathol 6:435–448
Redline RW, Hassold T et al (1998) Determinants of villous trophoblastic hyperplasia in spontaneous abortions. Mod Pathol 11(8):762–768
Redline RW, Jiang JG et al (2003) Discordancy for maternal floor infarction in dizygotic twin placentas. Hum Pathol 34:822–824
Redline RW, Minich N et al (2007) Placental lesions as predictors of cerebral palsy and abnormal neurocognitive function in extremely low birth weight infants (<1kg). Pediatr Dev Pathol 10:282–292
Redline RW, O' Riordan MA (2000) Placental lesions associated with cerebral palsy and neurologic impairment following term birth. Arch Pathol Lab Med 124:1785–1791
Redline RW, Pappin A (1995) Fetal thrombotic vasculopathy: the clinical significance of extensive avascular villi. Hum Pathol 26:80–85
Redline R, Patterson R (1993) Villitis of unknown etiology is associated with major infiltration of fetal tissues by maternal cells. Am J Pathol 143:332–336
Redline RW, Patterson P (1994) Patterns of placental injury: correlation with gestational age, placental weight, and clinical diagnosis. Arch Pathol Lab Med 118:698–701
Redline RW, Patterson P (1995) Preeclampsia is associated with an excess of proliferative immature intermediate trophoblast. Hum Pathol 26:594–600
Redline RW, Wilson-Costello D et al (1998) Placental lesions associated with neurologic impairment and cerebral palsy in very low birth weight infants. Arch Pathol Lab Med 122:1091–1098
Redline RW, Wilson-Costello D et al (1999) Chronic peripheral separation of placenta. The significance of diffuse chorioamniotic hemosiderosis. Am J Clin Pathol 111:804–810
Resnik R (2002) Intrauterine growth restriction. Obstet Gynecol 99:490–496
Reynolds MA, Schieve LA et al (2003) Trends in multiple births conceived using assisted reproductive technology, United States, 1997–2000. Pediatrics 111:1159–1162
Rigano S, Bozzo M et al (2001) Early and persistent reduction in umbilical vein flow in the growth restricted fetus: A longitudinal study. Am J Obstet Gynecol 185:834–838
Rodger MA, Paidas M et al (2008) Inherited thrombophilia and pregnancy complications revisited. Obstet Gynecol 112:320–324
Rodriguez MM, Chaves F et al (2002) Value of autopsy in nonimmune hydrops fetalis: Series of 51 stillborn fetuses. Pediatr Devel Pathol 5:365–374
Rogers BB, Alexander JM et al (2002) Umbilical vein interleukin-6 levels correlate with the severity of placental inflammation and gestational age. Hum Pathol 33:335–340
Salafia CM (1997) Placental pathology of fetal growth restriction. Clin Obstet Gynaecol 40:740–749
Salafia CM, Cowchock FS (1997) Placental pathology and antiphospholipid antibodies: a descriptive study. Am J Perinatol 14(8):435–441
Salafia CM, Pezzullo JC et al (1997) Placental pathology of absent and reversed end-diastolic flow in growth-restricted fetuses. Obstet Gynecol 90:830–836
Sander CH (1980) Hemorrhagic endovasculitis and hemorrhagic villitis of the placenta. Arch Pathol Lab Med 104:371–373
Sander CM, Gilliland D et al (2002) Livebirths with placental hemorrhagic vasculitis. Interlesional relationships and perinatal outcomes. Arch Pathol Lab Med 126:157–164
Sato Y, Benirschke K (2006) Increased prevalence of fetal thrombi in monochorionic-twin placentas. Pediatrics 117(1):e113–e117
Sato Y, Benirschke K (2006) Umbilical arterial thrombosis with vascular wall necrosis: clinicopathologic findings of 11 cases. Placenta 27:715–718
Scott JM (1983) Fibrinous vasculosis in the human placenta. Placenta 4:87–100
Sebire NJ, Backos M et al (2002) Placental massive perivillous fibrin deposition associated with antiphospholipid antibody syndrome. Br J Obstet Gynaecol 109:570–573
Sebire NJ, Sepulveda W (2008) Correlating placental pathology with ultrasound findings. J Clin Pathol 61:1276–1284
Sepulveda W, Corral E et al (2003) Umbilical artery aneurysm: prenatal identification in three fetuses with trisomy 18. Ultra Obstet Gynecol 21:292–296
Shamonki JM, Salmon JE et al (2007) Excessive complement is associated with placental injury in patients with antiphospholipid antibodies. Am J Obstet Gynecol 196(2):167.e1–167.e5
Shanklin DR, Scott JS (1975) Massive subchorial thrombohaematoma. (Breus’ mole). Br J Obstet Gynaecol 82:476–487
Shekhawat P, Matern D et al (2005) Fetal fatty acid oxidation disorders, their effect on maternal health and neonatal outcome: Impact of expanded newborn screening on their diagnosis and management. Pediatr Res 57:78R–86R
Shih I-M, Seidman JD et al (1999) Placental site nodule and characterization of distinctive types of intermediate trophoblast. Hum Pathol 30:687–694
Sienko A, Altshuler G (1999) Meconium-induced umbilical vascular necrosis in abortuses and fetuses: a histopathologic study for cytokines. Obstet Gynecol 94:415–420
Silver RK, Dooley SL et al (1987) Umbilical cord size and amniotic fluid volume in prolonged pregnancy. Am J Obstet Gynecol 157:716–720
Soernes T (1995) Umbilical cord encirclements and fetal growth restriction. Obstet Gynecol 86:725–728
Sohan K, Carroll SG et al (2001) Analysis of outcome in hydrops fetalis in relation to gestational age at diagnosis, cause and treatment. Acta Obstet Gynecol Scand 80:726–730
Soma H, Watanabe Y et al (1996) Chorangiosis and chorangioma in three cohorts of placentas from Nepal, Tibet, and Japan. Reprod Fertil Devel 7:1533–1538
Souter VL, Kapur RP et al (2003) A report of dizygous monochorionic twins. NEJM 349:154–158
Steffensen T, Gilbert-Barness E et al (2008) Placental pathology in TRAP sequence: clinical and pathogenetic implication. Fetal Pediatr Path 27:13–29
Tan TYT, Sepulveda W (2003) Acardiac twin: a systematic review of minimally invasive treatment modalities. Ultrasound Obstet Gynaecol II 22:409–419
Teramo KA, Widness JA (2008) Increased fetal plasma and amniotic fluid erythropoetin concentrations: markers of intrauterine hypoxia. Neonatology 95(2):105–116
Torpin R (1965) Amniochorionic mesoblastic fibrous strings and amnionic bands: associated contricting fetal malformations of fetal death. Am J Obstet Gynecol 91:65–75
Trainor B, Tubman R (2006) The emerging pattern of hydrops fetalis-incidence, etiology, and management. Ulster Med J 75:185–186
Turan S, Miller J et al (2008) Integrated testing and management in fetal growth restriction. Semin Perinatol 32:194–200
Venkatesha S, Toporsian M et al (2006) Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med 12:642–649
Vernof K, Benirschke K et al (1992) Maternal floor infarction: Relation to X cells, major basic protein, and adverse perinatal outcome. Am J Obstet Gynecol 167:1355–1363
Viscardi RM, Sun CC CC (2001) Placental lesion multiplicity: risk factor for IUGR and neonatal cranial ultrasound abnormalities. Early Hum Devel 62:1–10
Waters BL, Ashikaga T (2006) Significance of perivillous fibrin/oid deposition in uterine evacuation specimens. Am J Surg Pathol 30:760–765
Weber MA, Nikkels PGJ et al (2006) Co-occurrence of massive perivillous fibrin deposition and chronic intervillositis: case report. Pediatr Dev Pathol 9:234–238
Wilkins-Haug L, Quade B et al (2006) Confined placental mosaicism as a risk factor among newborns with fetal growth restriction. Prenat Diagn 26:428–432
Wong AE, Sepulveda W (2005) Acardiac anomaly: current issues in prenatal assessment and treatment. Prenat Diagn 25:796–806
Wyatt S, Kraus FT et al (2005) The correlation between sampling site and gene expression in the term human placenta. Placenta 26:372–379
Yeruchimovich M, Dollberg S et al (1999) Nucleated red blood cells in infants of smoking mothers. Obstet Gynecol 93:403–406
Zhang J, Kraus FT et al (1985) Chorioamnionitis: a comparative histologic, bacteriologic, and clinical study. Int J Gynecol Pathol 4:1–10
Ziska Z, Fait T et al (2008) ABO fetomaternal compatibility poses a risk for massive fetomaternal transplacental hemorrhage. Acta Obstet Gynecol Scand 87:1011–1014
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Gersell, D.J., Kraus, F.T. (2011). Diseases of the Placenta. In: Kurman, R.J., Ellenson, L.H., Ronnett, B.M. (eds) Blaustein’s Pathology of the Female Genital Tract. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-0489-8_19
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DOI: https://doi.org/10.1007/978-1-4419-0489-8_19
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4419-0488-1
Online ISBN: 978-1-4419-0489-8
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