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Metastatic Tumors of the Ovary

  • Melinda F. Lerwill
  • Robert H. Young

Abstract

Tumors that spread to the ovary from elsewhere are an important group of ovarian neoplasms because the misinterpretation of cases encountered as surgical pathology specimens may have significant adverse consequences for the patient. The spread may be from adjacent sites by direct local extension or from distant extragenital sites [27, 44, 61, 66, 90, 94, 111, 145, 152, 155, 161, 162]. The latter tumors are truly metastatic, whereas the designation “metastatic” is sometimes not used for those that are secondary from local sites. However, for simplicity, this discussion includes spread to the ovary from all sites.

Keywords

Ovarian Tumor Small Cell Carcinoma Granulosa Cell Tumor Endometrial Stromal Sarcoma Ovarian Metastasis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Abdul-Hafeez M, Akhtar M, Aqeel HSB, Kidess EA (1987) Placental site trophoblastic tumor: report of a case with review of literature. Ann Saudi Med 7:340–344Google Scholar
  2. 2.
    Abu-Rustum NR, Barakat RR, Curtin JP (1997) Ovarian and uterine disease in women with colorectal cancer. Gynecol Oncol 89:85–87CrossRefGoogle Scholar
  3. 3.
    Acosta-Sison H (1958) The relative frequency of various anatomic sites as the point of first metastasis in 32 cases of chorionepithelioma. Am J Obstet Gynecol 75:1149–1152PubMedGoogle Scholar
  4. 4.
    Agoff SN, Lamps LW, Philip AT, Amin MB, Schmidt RA, True LD, Folpe AL (2000) Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary neuroendocrine tumors. Mod Pathol 13:238–242PubMedCrossRefGoogle Scholar
  5. 5.
    Amorn Y, Knight WA (1978) Primary linitis plastica of the colon: report of two cases and review of the literature. Cancer (Phila) 41:2420–2425CrossRefGoogle Scholar
  6. 6.
    Baker PM, Clement PB, Young RH (2005) Malignant peritoneal mesothelioma in women. A study of 75 cases with emphasis on their morphologic spectrum and differential diagnosis. Am J Clin Pathol 123:724–737PubMedCrossRefGoogle Scholar
  7. 7.
    Baker PM, Oliva E (2004) Immunohistochemistry as a tool in the differential diagnosis of ovarian tumors: an update. Int J Gynecol Pathol 24:39–55Google Scholar
  8. 8.
    Beck RP, Latour JPA (1963) Necropsy reports on 36 cases of endometrial carcinoma. Am J Obstet Gynecol 85:307–311PubMedGoogle Scholar
  9. 9.
    Berezowski K, Stastny JF, Kornstein MJ (1996) Cytokeratins 7 and 20 and carcinoembryonic antigen in ovarian and colonic carcinoma. Mod Pathol 9:426–429PubMedGoogle Scholar
  10. 10.
    Bhargava R, Beriwal S, Dabbs DJ (2007) Mammaglobin vs GCDFP-15. An immunohistologic validation survey for sensitivity and specificity. Am J Clin Pathol 127:103–113PubMedCrossRefGoogle Scholar
  11. 11.
    Birnkrant A, Sampson J, Sugarbaker PH (1986) Ovarian metastasis from colorectal cancer. Dis Colon Rectum 29:767–771PubMedCrossRefGoogle Scholar
  12. 12.
    Brogioni S, Viacava P, Tomisti L, Martino E, Macchia E (2007) A special case of bilateral metastases in a woman with papillary carcinoma of the thyroid. Exp Clin Endocrinol Diabetes 115:397–400PubMedCrossRefGoogle Scholar
  13. 13.
    Brown BL, Scharifker DA, Gordon R, Deppe GG, Cohen CJ (1980) Bronchial carcinoid tumor with ovarian metastasis. A light microscopic and ultrastructural study. Cancer 46:543–546PubMedCrossRefGoogle Scholar
  14. 14.
    Bullon A, Arseneau J, Prat J, Young RH, Scully RE (1981) Tubular Krukenberg tumor. A problem in histopathologic diagnosis. Am J Surg Pathol 5:225–232PubMedCrossRefGoogle Scholar
  15. 15.
    Bunker ML (1959) The terminal findings in endometrial carcinoma. Am J Obstet Gynecol 77:530–538PubMedGoogle Scholar
  16. 16.
    Cameron RI, Ashe P, O’Rourke DM, Foster H, McCluggage WG (2003) A panel of immunohistochemical stains assists in the distinction between ovarian and renal clear cell carcinoma. Int J Gynecol Pathol 22:272–276PubMedCrossRefGoogle Scholar
  17. 17.
    Carlson JW, Nucci MR, Brodsky J, Crum CP, Hirsch MS (2007) Biomarker-assisted diagnosis of ovarian, cervical and pulmonary small cell carcinomas: the role of TTF-1, WT-1 and HPV analysis. Histopathology 51:305–312PubMedCrossRefGoogle Scholar
  18. 18.
    Caron P, Roche H, Gorguet B, Martel P, Bennet A, Carton M (1990) Mammary ovarian metastases with stromal cell hyperplasia and postmenopausal virilization. Cancer (Phila) 66:1221–1224CrossRefGoogle Scholar
  19. 19.
    Che M, Tornos C, Deavers MT (2001) Ovarian mixed-epithelial carcinomas with a microcystic pattern and signet-ring cells. Int J Gynecol Pathol 20:323–328PubMedCrossRefGoogle Scholar
  20. 20.
    Chen ZME, Wang HL (2004) Alteration of cytokeratin 7 and cytokeratin 20 expression profile is uniquely associated with tumorigenesis of primary adenocarcinoma of the small intestine. Am J Surg Pathol 28:1352–1359PubMedCrossRefGoogle Scholar
  21. 21.
    Chu PG, Weiss LM (2004) Immunohistochemical characterization of signet-ring cell carcinomas of the stomach, breast, and colon. Am J Clin Pathol 121:884–892PubMedCrossRefGoogle Scholar
  22. 22.
    Clement PB, Young RH, Scully RE (1996) Malignant mesotheliomas presenting as ovarian masses. A report of nine cases, including two primary ovarian mesotheliomas. Am J Surg Pathol 20:1067–1080PubMedCrossRefGoogle Scholar
  23. 23.
    Creasman WT, Lukeman J (1972) Role of the fallopian tube in dissemination of malignant cells in corpus cancer. Cancer (Phila) 20:456–457CrossRefGoogle Scholar
  24. 24.
    Curtin JP, Barakat RR, Hoskins WJ (1994) Ovarian disease in women with breast cancer. Obstet Gynecol 84:449–452PubMedGoogle Scholar
  25. 25.
    Daya D, Nazerali L, Frank GL (1992) Metastatic ovarian carcinoma of large intestinal origin simulating primary ovarian carcinoma. A clinicopathologic study of 25 cases. Am J Clin Pathol 97:751–758PubMedGoogle Scholar
  26. 26.
    DeCostanzo DC, Elias JM, Chumas JC (1997) Necrosis in 84 ovarian carcinomas: a morphologic study of primary versus metastatic colonic cancer with a selective immunohistochemical analysis of cytokeratin subtypes and carcinoembryonic antigen. Int J Gynecol Pathol 16:245–249PubMedCrossRefGoogle Scholar
  27. 27.
    Demopoulos RI, Touger L, Dubin N (1987) Secondary ovarian carcinoma: a clinical and pathological evaluation. Int J Gynecol Pathol 6:166–175PubMedCrossRefGoogle Scholar
  28. 28.
    Diddle AW (1955) Krukenberg tumors: diagnostic problem. Cancer (Phila) 8:1026–1034CrossRefGoogle Scholar
  29. 29.
    DiLoreto C, Di Lauro V, Puglisi F et al (1997) Immunocytochemical expression of tissue specific transcription factor-1 in lung carcinoma. J Clin Pathol 50:30–32CrossRefGoogle Scholar
  30. 30.
    Eichhorn JH, Young RH, Scully RE (1993) Non-pulmonary small cell carcinomas of extragenital origin metastatic to the ovary: a report of seven cases. Cancer (Phila) 71:177–186CrossRefGoogle Scholar
  31. 31.
    Eifel P, Hendrickson M, Ross J, Ballon S, Martinez A, Kempson R (1982) Simultaneous presentation of carcinoma involving the ovary and the uterine corpus. Cancer (Phila) 50:163–170CrossRefGoogle Scholar
  32. 32.
    Elhajj M, Mazurka J, Daya D (2002) Desmoplastic small round cell tumor presenting in the ovaries: report of a case and review of the literature. Int J Gynecol Cancer 12:760–763PubMedCrossRefGoogle Scholar
  33. 33.
    Elishaev E, Gilks CB, Miller D, Srodon M, Kurman RJ, Ronnett BM (2005) Synchronous and metachronous endocervical and ovarian neoplasms. Evidence supporting interpretation of the ovarian neoplasms as metastatic endocervical adenocarcinomas simulating primary ovarian surface epithelial neoplasms. Am J Surg Pathol 29:281–294PubMedCrossRefGoogle Scholar
  34. 34.
    Fitzgibbons PL, Martin SE, Simmons TJ (1987) Malignant melanoma metastatic to the ovary. Am J Surg Pathol 11:959–964PubMedCrossRefGoogle Scholar
  35. 35.
    Gagnon Y, Tetu B (1989) Ovarian metastases of breast carcinoma. A clinicopathologic study of 59 cases. Cancer (Phila) 64:892–898CrossRefGoogle Scholar
  36. 36.
    Gokden N, Gokden M, Phan DC, McKenney JK (2008) The utility of PAX-2 in distinguishing metastatic clear cell renal cell carcinoma from its morphologic mimics. An immunohistochemical study with comparison to renal cell carcinoma marker. Am J Surg Pathol 32:1462–1467PubMedCrossRefGoogle Scholar
  37. 37.
    Goldblum J, Hart WR (1995) Localized and diffuse mesotheliomas of the genital tract and peritoneum in women. A clinicopathological study of nineteen true mesothelial neoplasms, other than adenomatoid tumors, multicystic mesotheliomas and localized fibrous tumors. Am J Surg Pathol 19:1124–1137PubMedCrossRefGoogle Scholar
  38. 38.
    Graffner HOL, Alm POA, Oscarson JEA (1983) Prophylactic oophorectomy in colorectal carcinoma. Am J Surg 146:233–235PubMedCrossRefGoogle Scholar
  39. 39.
    Green TH Jr, Scully RE (1962) Tumors of the fallopian tube. Clin Obstet Gynecol 5:886–906PubMedCrossRefGoogle Scholar
  40. 40.
    Green LK, Silva EG (1989) Hepatoblastoma in an adult with metastasis to the ovaries. Am J Clin Pathol 92:110–115PubMedGoogle Scholar
  41. 41.
    Gupta D, Deavers MT, Silva EG et al (2004) Malignant melanoma involving the ovary. A clinicopathologic and immunohistochemical study of 23 cases. Am J Surg Pathol 28:771–780PubMedCrossRefGoogle Scholar
  42. 42.
    Hale RW (1968) Krukenberg tumor of the ovaries. A review of 81 records. Obstet Gynecol 32:221–225PubMedGoogle Scholar
  43. 43.
    Harris M, Howell A, Chrissohou M, Swindell RIC, Hudson M, Sellwood RA (1984) A comparison of the metastatic pattern of infiltrating lobular carcinoma and infiltrating duct carcinoma of the breast. Br J Cancer 50:23–30PubMedCrossRefGoogle Scholar
  44. 44.
    Hart WR (2005) Diagnostic challenge of secondary (metastatic) ovarian tumors simulating primary endometrioid and mucinous neoplasms. Pathol Int 55:321–343CrossRefGoogle Scholar
  45. 45.
    Hassan R, Kreitman RJ, Pastan I, Willingham MC (2005) Localization of mesothelin in epithelial ovarian cancer. Mol Morphol 13:243–247Google Scholar
  46. 46.
    Hayashi Y, Kikuchi F, Oka T et al (1988) Rhabdomyosarcoma with bone marrow metastasis simulating acute leukemia. Report of two cases. Acta Pathol Jpn 38:789–798PubMedGoogle Scholar
  47. 47.
    Hecht JL, Pinkus JL, Weinstein LJ et al (2001) The value of thyroid transcription factor-1 in cytologic preparations as a marker for metastatic adenocarcinoma of lung origin. Am J Clin Pathol 116:483–488PubMedCrossRefGoogle Scholar
  48. 48.
    Hines JR, Gordon RT, Widger C et al (1976) Cystosarcoma phyllodes metastatic to a Brenner tumor of the ovary. Arch Surg 111:299–300PubMedCrossRefGoogle Scholar
  49. 49.
    Holtz F, Hart WR (1982) Krukenberg tumors of the ovary. A clinicopathologic analysis of 27 cases. Cancer (Phila) 50:2438–2447CrossRefGoogle Scholar
  50. 50.
    Hopping RA, Dockerty MB, Masson JC (1942) Carcinoid tumor of the appendix. Report of a case in which extensive intra-abdominal metastases occurred, including involvement of the right ovary. Arch Surg 45:613–622CrossRefGoogle Scholar
  51. 51.
    Hristov AC, Young RH, Vang R, Yemelyanova AV, Seidman JD, Ronnett BM (2007) Ovarian metastases of appendiceal tumors with goblet cell carcinoid-like and signet ring cell patterns: A report of 30 cases. Am J Surg Pathol 31:1502–1511PubMedCrossRefGoogle Scholar
  52. 52.
    Hsiu J-G, Kemp GM, Singer GA, Rawls WH, Siddiky MA (1991) Transitional cell carcinoma of the renal pelvis with ovarian metastasis. Gynecol Oncol 41:178–181PubMedCrossRefGoogle Scholar
  53. 53.
    Insabato L, DeRosa G, Franco R et al (2003) Ovarian metastasis from renal cell carcinoma: a report of three cases. Int J Surg Pathol 11:309–312PubMedCrossRefGoogle Scholar
  54. 54.
    Irving JA, Lerwill MF, Young RH (2005) Gastrointestinal stromal tumors metastatic to the ovary. A report of five cases. Am J Surg Pathol 29:920–926PubMedCrossRefGoogle Scholar
  55. 55.
    Irving JA, Vasques DR, McGuinness TB, Young RH (2006) Krukenberg tumor of renal pelvic origin: report of a case with selected comments on ovarian tumors metastatic from the urinary tract. Int J Gynecol Pathol 25:147–150PubMedCrossRefGoogle Scholar
  56. 56.
    Irving JA, Young RH (2005) Lung carcinoma metastatic of the ovary. A clinicopathologic study of 32 cases emphasizing their morphologic spectrum and problems in differential diagnosis. Am J Surg Pathol 29:997–1006PubMedGoogle Scholar
  57. 57.
    Ji H, Isacson C, Seidman JD, Kurman RJ, Ronnett BM (2002) Cytokeratins 7 and 20, Dpc4, and MUC5AC in the distinction of metastatic mucinous carcinomas in the ovary from primary ovarian mucinous tumors: Dpc4 assists in identifying metastatic pancreatic carcinomas. Int J Gynecol Pathol 21:391–400PubMedCrossRefGoogle Scholar
  58. 58.
    Judson K, McCormick C, Vang R, Yemelyanova AV, Wu LSF, Bristow RE, Ronnett BM (2008) Women with undiagnosed colorectal adenocarcinomas presenting with ovarian metastases: Clinicopathologic features and comparison with women having known colorectal adenocarcinomas and ovarian involvement. Int J Gynecol Pathol 27:182–190PubMedGoogle Scholar
  59. 59.
    Kaminski PF, Norris HJ (1984) Coexistence of ovarian neoplasms and endocervical adenocarcinoma. Obstet Gynecol 64:553–556PubMedGoogle Scholar
  60. 60.
    Kanner WA, Galgano MT, Stoler MH, Mills SE, Atkins KA (2008) Distinguishing breast carcinoma from mullerian serous carcinoma with mammaglobin and mesothelin. Int J Gynecol Pathol 27:491–495PubMedCrossRefGoogle Scholar
  61. 61.
    Karsh J (1951) Secondary malignant disease of the ovaries. A study of 72 autopsies. Am J Obstet Gynecol 61:154–160PubMedGoogle Scholar
  62. 62.
    Kaufmann O, Dietel M (2000) Thyroid transcription factor-1 is the superior immunohistochemical marker for pulmonary adenocarcinomas and large cell carcinomas compared to surfactant proteins A and B. Histopathology 36:8–16PubMedCrossRefGoogle Scholar
  63. 63.
    Khunamornpong S, Lerwill MF, Siriaunkgul S, Suprasert P, Pojchamarnwiputh S, Chiangmai WN, Young RH (2008) Carcinoma of extrahepatic bile ducts and gallbladder metastatic to the ovary: a report of 16 cases. Int J Gynecol Pathol 27:366–379PubMedCrossRefGoogle Scholar
  64. 64.
    Khunamornpong S, Siriaunkgul S, Chunduan A (1999) Metastatic hepatocellular carcinoma of the ovary. Int J Gynecol Obstet 64:189–191CrossRefGoogle Scholar
  65. 65.
    Khunamornpong S, Siriaunkgul S, Suprasert P, Pojchamarnwiputh S, Chiangmai WN, Young RH (2007) Intrahepatic cholangiocarcinoma metastatic to the ovary: A report of 16 cases of an underemphasized form of secondary tumor of the ovary that may mimic primary neoplasia. Am J Surg Pathol 31:1788–1799PubMedCrossRefGoogle Scholar
  66. 66.
    Khunamornpong S, Suprasert P, Chiangmai WN, Siriaunkgul S (2006) Metastatic tumors to the ovaries: a study of 170 cases in Northern Thailand. Int J Gynecol Cancer 16:132–138PubMedCrossRefGoogle Scholar
  67. 67.
    Khunamornpong S, Suprasert PS, Pojchamarnwiputh S, Chiangmai WN, Settakorn J, Siriaunkgul S (2006) Primary and metastatic mucinous adenocarcinomas of the ovary: evaluation of the diagnostic approach using tumor size and laterality. Gynecol Oncol 101:152–157PubMedCrossRefGoogle Scholar
  68. 68.
    Kim KR, Lee HI, Lee SK, Ro JY, Robboy SJ (2007) Is stromal microinvasion in primary mucinous ovarian tumors with “mucin granuloma” true invasion? Am J Surg Pathol 31:546–554PubMedCrossRefGoogle Scholar
  69. 69.
    Kim K-R, Scully RE (1990) Peritoneal keratin granulomas with carcinomas of endometrium and ovary and atypical polypoid adenomyoma of endometrium. A clinicopathological analysis of 22 cases. Am J Surg Pathol 14:925–932PubMedCrossRefGoogle Scholar
  70. 70.
    Kindelberger DW, Lee Y, Miron A, Hirsch MS, Feltmate C, Medeiros F, Callahan MJ, Garner EO, Gordon RW, Birch C, Berkowitz RS, Muto MG, Crum CP (2007) Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: evidence for a causal relationship. Am J Surg Pathol 31:161–169PubMedCrossRefGoogle Scholar
  71. 71.
    Kiyokawa T, Young RH, Scully RE (2006) Krukenberg tumors of the ovary. A clinicopathologic analysis of 120 cases with emphasis on their variable pathologic manifestations. Am J Surg Pathol 31:277–299Google Scholar
  72. 72.
    Kubba LA, McCluggage WG, Liu J, Malpica A, Euscher ED, Silva EG, Deavers MT (2008) Thyroid transcription factor-1 expression in ovarian epithelial neoplasms. Mod Pathol 21:485–490PubMedCrossRefGoogle Scholar
  73. 73.
    Kuo T-T, Hsueh S (1984) Mucicarminophilic histiocytosis. A polyvinylpyrrolidone (PVP) storage disease simulating signet-ring cell carcinoma. Am J Surg Pathol 8:419–428PubMedCrossRefGoogle Scholar
  74. 74.
    Kurek R, Von Knoblock R, Feek U, Heidenreich A, Hofmann R (2001) Local recurrence of an oncocytic adrenocortical carcinoma with ovary metastasis. J Urol 166:985PubMedCrossRefGoogle Scholar
  75. 75.
    Lash RH, Hart WR (1987) Intestinal adenocarcinomas metastatic to the ovaries. A clinicopathological evaluation of 22 cases. Am J Surg Pathol 11:114–121PubMedCrossRefGoogle Scholar
  76. 76.
    Lee MJ, Lee HS, Kim WH, Choi Y, Yang M (2003) Expressions of mucins and cytokeratins in primary carcinomas of the digestive system. Mod Pathol 16:403–410PubMedCrossRefGoogle Scholar
  77. 77.
    Lee AHS, Paish EC, Marchio C, Sapino A, Schmitt FC, Ellis IO, Reis-Filho JS (2007) The expression of Wilms’ tumour-1 and Ca125 in invasive micropapillary carcinoma of the breast. Histopathology 51:824–828PubMedCrossRefGoogle Scholar
  78. 78.
    Lee KR, Young RH (2003) The distinction between primary and metastatic mucinous carcinomas of the ovary. Am J Surg Pathol 2:281–292CrossRefGoogle Scholar
  79. 79.
    Leroy X, Farine MO, Buob D, Wacrenier A, Copin MC (2007) Diagnostic value of cytokeratin 7, CD10 and mesothelin in distinguishing ovarian clear cell carcinoma from metastasis of renal clear cell carcinoma. Histopathology 51:846–876CrossRefGoogle Scholar
  80. 80.
    Lerwill MF (2004) Current practical applications of diagnostic immunohistochemistry in breast pathology. Am J Surg Pathol 28:1076–1091PubMedCrossRefGoogle Scholar
  81. 81.
    Lerwill MF, Young RH (2006) Ovarian metastases of intestinal-type gastric carcinoma. A clinicopathologic study of 4 cases with contrasting features to those of the Krukenberg tumor. Am J Surg Pathol 31:1382–1388CrossRefGoogle Scholar
  82. 82.
    Lewis MR, Deavers MT, Silva EG, Malpica A (2006) Ovarian involvement by metastatic colorectal adenocarcinoma. Still a diagnostic challenge. Am J Surg Pathol 30:177–184PubMedCrossRefGoogle Scholar
  83. 83.
    LiVolsi VA, Merino MJ, Schwartz PE (1983) Coexistent endocervical adenocarcinoma and mucinous adenocarcinoma of ovary: a clinicopathological study of four cases. Int J Gynecol Pathol 1:391–402PubMedCrossRefGoogle Scholar
  84. 84.
    Logani S, Baloch ZW, Snyder PJ, Weinstein R, LiVolvi VA (2001) Cystic ovarian metastasis from papillary thyroid carcinoma: a case report. Thyroid 11:1073–1075PubMedCrossRefGoogle Scholar
  85. 85.
    Logani S, Oliva E, Amin MB, Folpe AL, Cohen C, Young RH (2003) Immunoprofile of ovarian tumors with putative transitional cell (urothelial) differentiation using novel urothelial markers. Histogenic and diagnostic implications. Am J Surg Pathol 27:1434–1441PubMedCrossRefGoogle Scholar
  86. 86.
    Logani S, Oliva E, Arnell PM, Amin MB, Young RH (2005) Use of novel immunohistochemical markers expressed in colonic adenocarcinoma to distinguish primary ovarian tumors from metastatic colorectal carcinoma. Mod Pathol 18:19–25PubMedCrossRefGoogle Scholar
  87. 87.
    Longacre TA, O’Hanlan K, Hendrickson MR (1996) Adenoid cystic carcinoma of the submandibular gland with symptomatic ovarian metastases. Int J Gynecol Pathol 15:349–355PubMedCrossRefGoogle Scholar
  88. 88.
    Lumb G, Mackenzie DH (1959) The incidence of metastases in adrenal glands and ovaries removed for carcinoma of the breast. Cancer (Phila) 12:521–526CrossRefGoogle Scholar
  89. 89.
    MacKeigan JM, Ferguson JA (1979) Prophylactic oophorectomy and colorectal cancer in premenopausal patients. Dis Colon Rectum 22:401–405PubMedCrossRefGoogle Scholar
  90. 90.
    Mazur MT, Hsueh S, Gersell DJ (1984) Metastases to the female genital tract. Analysis of 325 cases. Cancer (Phila) 53:1978–1984CrossRefGoogle Scholar
  91. 91.
    McCluggage WG (2008) Immunohistochemical markers as a diagnostic aid in ovarian pathology. Diagn Histopathol 14:335–351CrossRefGoogle Scholar
  92. 92.
    McCluggage WG, Bissonnette JP, Young RH (2006) Primary malignant melanoma of the ovary: A report of 9 definite or probable cases with emphasis on their morphologic diversity and mimicry of other primary and secondary ovarian neoplasms. Int J Gynecol Pathol 25:321–329PubMedCrossRefGoogle Scholar
  93. 93.
    McCluggage WG, Wilkinson N (2005) Metastatic neoplasms involving the ovary: a review with an emphasis on morphological and immunohistochemical features. Histopathology 47:231–247PubMedCrossRefGoogle Scholar
  94. 94.
    McCluggage WG, Young RH (2005) Immunohistochemistry as a diagnostic aid in the evaluation of ovarian tumors. Semin Diagn Pathol 22:3–32PubMedCrossRefGoogle Scholar
  95. 95.
    McCluggage WG, Young RH (2008) Primary ovarian mucinous tumors with signet ring cells: report of three cases with discussion of so-called primary Krukenberg tumor. Am J Surg Pathol 32:1373–1379PubMedCrossRefGoogle Scholar
  96. 96.
    McKenney JK, Soslow RA, Longacre TA (2008) Ovarian mature teratomas with mucinous epithelial neoplasms: Morphologic heterogeneity and association with pseudomyxoma peritonei. Am J Surg Pathol 32:645–655PubMedCrossRefGoogle Scholar
  97. 97.
    Merino MJ, Edmonds P, LiVolsi V (1985) Appendiceal carcinoma metastatic to the ovaries and mimicking primary ovarian tumors. Int J Gynecol Pathol 4:110–120PubMedCrossRefGoogle Scholar
  98. 98.
    Meyer WH, Yu GW, Milvenan ES, Jeffs RD, Kaizer H, Leventhal BG (1979) Ovarian involvement in neuroblastoma. Med Pediatr Oncol 7:49–54PubMedCrossRefGoogle Scholar
  99. 99.
    Milingos D, Doumplis D, Savage P, Seckl M, Lindsay I, Smith JR (2007) Placental site trophoblastic tumor with an ovarian metastasis. Int J Gynecol Cancer 17:925–927PubMedCrossRefGoogle Scholar
  100. 100.
    Misdraji J, Yantiss RK, Graeme-Cook FM, Balis UJ, Young RH (2003) Appendiceal mucinous neoplasms. A clinicopathologic analysis of 107 cases. Am J Surg Pathol 27:1089–1103PubMedCrossRefGoogle Scholar
  101. 101.
    Monteagudo C, Merino MJ, Laporte N, Neumann RD (1991) Value of gross cystic disease fluid protein-15 in distinguishing metastatic breast carcinomas among poorly differentiated neoplasms involving the ovary. Hum Pathol 22:368–372PubMedCrossRefGoogle Scholar
  102. 102.
    Moritani S, Ichihara S, Hasegawa M, Endo T, Oiwa M, Yoshikawa K, Sato Y, Aoyama H, Hayashi T, Kushima R (2008) Serous papillary adenocarcinoma of the female genital organs and invasive micropapillary carcinoma of the breast. Are WT1, CA125, and GCDFP-15 useful in differential diagnosis? Hum Pathol 39:666–671PubMedCrossRefGoogle Scholar
  103. 103.
    Nguyen L, Brewer CA, DiSaia PJ (1998) Ovarian metastasis of Stage 1B1 squamous cell cancer of the cervix after radical parametrectomy and oophoropexy. Gynecol Oncol 68:198–200PubMedCrossRefGoogle Scholar
  104. 104.
    Nonaka D, Chiriboga L, Soslow RA (2008) Expression of Pax8 as a useful marker in distinguishing ovarian carcinomas from mammary carcinomas. Am J Surg Pathol 32:1566–1571PubMedCrossRefGoogle Scholar
  105. 105.
    Oberg KC, Wells K, Seraj IM et al (2002) ACTH-secreting islet cell tumor of the pancreas presenting as bilateral ovarian tumors and Cushing’s syndrome. Int J Gynecol Pathol 21:276–280PubMedCrossRefGoogle Scholar
  106. 106.
    Ohira S, Shiohara S, Itoh K et al (2003) Urachal adenocarcinoma metastatic to the ovaries: case report and literature review. Int J Gynecol Pathol 22:189–193PubMedCrossRefGoogle Scholar
  107. 107.
    Ohta Y, Suzuki T, Shiokawa A, Mitsuya T, Ota H (2005) Expression of CD10 and cytokeratins in ovarian and renal clear cell carcinoma. Int J Gynecol Pathol 24:239–245PubMedCrossRefGoogle Scholar
  108. 108.
    Oliva E, Musulen E, Prat J, Young RH (1993) Transitional cell carcinoma of the renal pelvis with symptomatic ovarian metastases. Int J Surg Pathol 2:231–236CrossRefGoogle Scholar
  109. 109.
    Onuma K, Dabbs DJ, Bhargava R (2008) Mammaglobin expression in the female genital tract: immunohistochemical analysis in benign and neoplastic endocervix and endometrium. Int J Gynecol Pathol 27:418–425PubMedCrossRefGoogle Scholar
  110. 110.
    Parker LP, Duong JL, Wharton JT, Malpica A, Silva EG, Deavers MT (2002) Desmoplastic small round cell tumor: report of a case presenting as a primary ovarian neoplasm. Eur J Gynaec Oncol 23:199–202Google Scholar
  111. 111.
    Petru E, Pickel H, Heydarfadai M, Lahousen M, Haas J, Schaider H, Tamussino K (1992) Nongenital cancers metastatic to the ovary. Gynecol Oncol 44:83–86PubMedCrossRefGoogle Scholar
  112. 112.
    Phillips V, McCluggage WG, Young RH (2006) Oxyphilic adenomatoid tumor of the ovary: a case report with discussion of the differential diagnosis of ovarian tumors with vacuoles and related spaces. Int J Gynecol Pathol 26:16–20CrossRefGoogle Scholar
  113. 113.
    Pins MR, Young RH, Crum CP, Leach IH, Scully RE (1997) Cervical squamous carcinoma in situ with superficial extension to corpus and tubes and invasion of tubes and ovaries. Int J Gynecol Pathol 16:272–278PubMedCrossRefGoogle Scholar
  114. 114.
    Pitluk H, Poticha SM (1983) Carcinoma of the colon and rectum in patients less than 40 years of age. Surg Gynecol Obstet 157:335–337PubMedGoogle Scholar
  115. 115.
    Pitman MB, Triratanachat S, Young RH, Oliva E (2003) Hepatocyte paraffin 1 antibody does not distinguish primary ovarian tumors with hepatoid differentiation from metastatic hepatocellular carcinoma. Int J Gynecol Pathol 23:58–64Google Scholar
  116. 116.
    Prayson RA, Hart WR, Petras RE (1994) Pseudo-myxoma peritonei. A clinicopathologic study of 19 cases with emphasis on site of origin and nature of associated ovarian tumors. Am J Surg Pathol 18:591–603PubMedGoogle Scholar
  117. 117.
    Rabban JT, Lerwill MF, McCluggage WG, Grenert JP, Zaloudek CJ (2009) Primary ovarian carcinoid tumors may express CDX-2: a potential pitfall in distinction from metastatic intestinal carcinoid tumors involving the ovary. Int J Gynecol Pathol 28:41–48PubMedCrossRefGoogle Scholar
  118. 118.
    Reis-Filho JS, Carrilho C, Valenti C et al (2000) Is TTF1 a good immunohistochemical marker to distinguish primary from metastatic lung adenocarcinomas? Pathol Res Pract 196:835–840PubMedCrossRefGoogle Scholar
  119. 119.
    Riopel MA, Ronnett BM, Kurman RJ (1999) Evaluation of diagnostic criteria and behavior of ovarian intestinal-type mucinous tumors. Atypical proliferative (borderline) tumors and intraepithelial, microinvasive, invasive, and metastatic carcinomas. Am J Surg Pathol 23:617–635PubMedCrossRefGoogle Scholar
  120. 120.
    Robboy SJ, Scully RE, Norris HJ (1974) Carcinoid metastatic to the ovary. A clinicopathologic analysis of 35 cases. Cancer (Phila) 33:798–811CrossRefGoogle Scholar
  121. 121.
    Ronnett BM, Kurman RJ, Shmookler BM, Sugarbaker PH, Young RH (1997) The morphologic spectrum of ovarian metastases of appendical adenocarcinomas. A clinicopathologic and immunohistochemical analysis of tumors often misinterpreted as primary ovarian tumors or metastatic tumors from other gastrointestinal sites. Am J Surg Pathol 2:1144–1155CrossRefGoogle Scholar
  122. 122.
    Ronnett BM, Kurman RJ, Zahn CM, Shmookler BM, Jablonski KA, Kass ME (1995) Pseudomyxoma peritonei in women. A clinicopathologic analysis of 30 cases with emphasis on site of origin, prognosis, and relationship to ovarian mucinous tumors of low malignant potential. Hum Pathol 26:509–524PubMedCrossRefGoogle Scholar
  123. 123.
    Ronnett BM, Shmookler BM, Diener-West M, Sugarbaker PH, Kurman RJ (1997) Immunohistochemical evidence supporting the appendiceal origin of pseudomyxoma peritonei in women. Int J Gynecol Pathol 16:1–9PubMedCrossRefGoogle Scholar
  124. 124.
    Ronnett BM, Yemelyanova AV, Vang R, Gilks CB, Miller D, Gravitt PE, Kurman RJ (2008) Endocervical adenocarcinomas with ovarian metastases. Analysis of 29 cases with emphasis on minimally invasive cervical tumors and the ability of the metastases to simulate primary ovarian neoplasms. Am J Surg Pathol 32:1835–1853PubMedCrossRefGoogle Scholar
  125. 125.
    Ronnett BM, Zahn CM, Kurman RJ, Kass ME, Sugarbaker PH, Shmookler BM (1995) Disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis: a clinicopathologic analysis of 109 cases with emphasis on distinguishing pathologic features, site of origin, prognosis, and relationship to “pseudomyxoma peritonei”. Am J Surg Pathol 19:1390–1408PubMedCrossRefGoogle Scholar
  126. 126.
    Saphir O (1951) Signet-ring cell carcinoma. Mil Surg 109:360–369PubMedGoogle Scholar
  127. 127.
    Sasaki E, Tsunoda N, Hatanaka Y, Mori N, Iwata H, Yatabe Y (2007) Breast-specific expression of MGB1/mammaglobin: an examination of 480 tumors from various organs and clinicopathological analysis of MGB1-positive breast cancers. Mod Pathol 20:208–214PubMedCrossRefGoogle Scholar
  128. 128.
    Scully RE, Richardson GS (1961) Luteinization of the stroma of metastatic cancer involving the ovary and its endocrine significance. Cancer (Phila) 14:827–840CrossRefGoogle Scholar
  129. 129.
    Seidman JD, Elsayed AM, Sobin LH, Tavassoli FA (1993) Association of mucinous tumors of the ovary and appendix. A clinicopathologic study of 25 cases. Am J Surg Pathol 17:22–34PubMedCrossRefGoogle Scholar
  130. 130.
    Seidman JD, Kurman RJ, Ronnett BM (2003) Incidence in routine practice with a new approach to improve intraoperative diagnosis. Primary and metastatic mucinous adenocarcinomas in the ovaries. Am J Surg Pathol 27:985–993PubMedCrossRefGoogle Scholar
  131. 131.
    Smale L (1980) Metastatic breast adenocarcinoma to Brenner tumors. Gynecol Oncol 9:251–253PubMedCrossRefGoogle Scholar
  132. 132.
    Soslow RA, Rouse RV, Hendrickson MR, Silva EG, Longacre TA (1996) Transitional cell neoplasms of the ovary and urinary bladder: a comparative immunohistochemical analysis. Int J Gynecol Pathol 15:257–265PubMedCrossRefGoogle Scholar
  133. 133.
    Spencer JR, Eriksen B, Garnett JE (1993) Metastatic renal tumor presenting as ovarian clear cell carcinoma. Urology 41:582–584PubMedCrossRefGoogle Scholar
  134. 134.
    Stewart CJR, Brennan BA, Hammond IG et al (2005) Accuracy of frozen section in distinguishing primary ovarian neoplasia from tumors metastatic to the ovary. Int J Gynecol Pathol 24:356–362PubMedCrossRefGoogle Scholar
  135. 135.
    Strosberg J, Nasir A, Cragun J, Gardner N, Kvols L (2007) Metastatic carcinoid tumor to the ovary: a clinicopathologic analysis of seventeen cases. Gynecol Oncol 106:65–68PubMedCrossRefGoogle Scholar
  136. 136.
    Sty JR, Kun LE, Casper JT (1980) Bone scintigraphy in neuroblastoma with ovarian metastasis. Wis Med J 79:28–29Google Scholar
  137. 137.
    Szych C, Staebler A, Connolly DC, Wu R, Cho KR, Ronnett BM (1999) Molecular genetic evidence supporting the clonality and appendiceal origin of pseudomyxoma peritonei in women. Am J Pathol 154:1849–1855PubMedCrossRefGoogle Scholar
  138. 138.
    Tabata M, Ichinoe K, Sakuragi N, Shina Y, Yamaguchi T, Mabuchi Y (1987) Incidence of ovarian metastasis in patients with cancer of the uterine cervix. Gynecol Oncol 28:255–261PubMedCrossRefGoogle Scholar
  139. 139.
    Tang LH, Shia J, Soslow RA, Dhall D, Wong WD, O’Reilly E, Qin J, Paty P, Weiser MR, Guillem J, Temple L, Sobin LH, Klimstra DS (2008) Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix. Am J Surg Pathol 32:1429–1443PubMedCrossRefGoogle Scholar
  140. 140.
    Toki N, Tsukamoto N, Kaku T et al (1991) Microscopic ovarian metastasis of the uterine cervical cancer. Gynecol Oncol 41:46–51PubMedCrossRefGoogle Scholar
  141. 141.
    Tornos C, Soslow R, Chen S et al (2005) Expression of WT1, CA 125, and GCDFP-15 as useful markers in the differential diagnosis of primary ovarian carcinomas versus metastatic breast cancer to the ovary. Am J Surg Pathol 29:1482–1489PubMedCrossRefGoogle Scholar
  142. 142.
    Tso PL, Bringaze WL III, Dauterive AH, Correa P, Cohn I Jr (1987) Gastric carcinoma in the young. Cancer (Phila) 59:1362–1365CrossRefGoogle Scholar
  143. 143.
    Ulbright TM, Roth LM (1985) Metastatic and independent cancers of the endometrium and ovary: a clinicopathologic study of 34 cases. Hum Pathol 16:28–34PubMedCrossRefGoogle Scholar
  144. 144.
    Ulbright TM, Roth LM (1985) Secondary tumors of the ovary. In: Roth LM, Czernobilsky B (eds) Tumors and tumor-like conditions of the ovary, vol 6, Contemporary issues in surgical pathology. Churchill-Livingstone, New York, pp 129–152Google Scholar
  145. 145.
    Ulbright TM, Roth LM, Stehman FB (1984) Secondary ovarian neoplasia. A clinicopathologic study of 35 cases. Cancer (Phila) 53:1164–1174CrossRefGoogle Scholar
  146. 146.
    Vakiani E, Young RH, Carcangiu ML, Klimstra DS (2008) Acinar cell carcinoma of the pancreas metastatic to the ovary. A report of 4 cases. Am J Surg Pathol 32:1540–1545PubMedCrossRefGoogle Scholar
  147. 147.
    Vang R, Gown AM, Barry TS, Wheeler DT, Yemelyanova A, Seidman JD, Ronnett BM (2006) Cytokeratins 7 and 20 in primary and secondary mucinous tumors of the ovary: analysis of coordinate immunohistochemical expression profiles and staining distribution in 179 cases. Am J Surg Pathol 30:1130–1139PubMedCrossRefGoogle Scholar
  148. 148.
    Vang R, Gown AM, Wu LSF, Barry TS, Wheeler DT, Yemelyanova A, Seidman JD, Ronnett BM (2006) Immunohistochemical expression of CDX2 in primary ovarian mucinous tumors and metastatic mucinous carcinomas involving the ovary: comparison with CK20 and correlation with coordinate expression of CK7. Mod Pathol 19:1421–1428PubMedCrossRefGoogle Scholar
  149. 149.
    Vang R, Gown AM, Zhao C, Barry TS, Isacson C, Richardson MS, Ronnett BM (2007) Ovarian mucinous tumors associated with mature cystic teratomas. Morphologic and immunohistochemical analysis identifies a subset of potential teratomatous origin that shares features of lower gastrointestinal tract mucinous tumors more commonly encountered as secondary tumors in the ovary. Am J Surg Pathol 31:854–869PubMedCrossRefGoogle Scholar
  150. 150.
    Vara A, Madrigal B, Veiga M, Diaz A, Garcia J, Calvo J (1998) Bilateral ovarian metastases from renal clear cell carcinoma. Acta Oncol (Stockh) 37:379–380CrossRefGoogle Scholar
  151. 151.
    Veras E, Srodon M, Neijstrom ES, Ronnett BM (2009) Metastatic HPV-related cervical adenocarcinomas presenting with thromboembolic events (Trousseau syndrome): clinicopathologic characteristics of two cases. Int J Gynecol Pathol 28:134–139PubMedCrossRefGoogle Scholar
  152. 152.
    Webb MJ, Decker DG, Mussey E (1975) Factors influencing survival. Cancer metastatic to the ovary. Obstet Gynecol 45:391–396PubMedGoogle Scholar
  153. 153.
    Wheelock MC, Putong P (1959) Ovarian metastases from adenocarcinomas of colon and rectum. Obstet Gynecol 14:291–295PubMedGoogle Scholar
  154. 154.
    Wick MR, Lillemoe TJ, Copland GT, Swanson PE, Manivel JC, Kiang DT (1989) Gross cystic disease fluid protein-15 as a marker for breast cancer: immunohistochemical analysis of 690 human neoplasms and comparison with alpha-lactalbumin. Hum Pathol 20:281–287PubMedCrossRefGoogle Scholar
  155. 155.
    Woodruff JD, Murthy YS, Bhaskar TN, Bordbar F, Tseng S-S (1970) Metastatic ovarian tumors. Am J Obstet Gynecol 107:202–209PubMedGoogle Scholar
  156. 156.
    Yakushiji M, Tazaki T, Nishimura H, Kato T (1987) Krukenberg tumors of the ovary: a clinicopathologic analysis of 112 cases. Acta Obstet Gynaecol Jpn 39:479–485Google Scholar
  157. 157.
    Yemelyanova AV, Vang R, Judson K, Wu LSF, Ronnett BM (2008) Distinction of primary and metastatic mucinous tumors involving the ovary: analysis of size and laterality data by primary site with reevaluation of an algorithm for tumor classification. Am J Surg Pathol 32:128–138PubMedCrossRefGoogle Scholar
  158. 158.
    Yoshida A, Shigematsu T, Mori H, Yoshida H, Fukunishi R (1981) Non-invasive thymoma with widespread blood-borne metastasis. Virchows Arch (Path Anat) 390:121–126CrossRefGoogle Scholar
  159. 159.
    Young RH (1995) Urachal adenocarcinoma metastatic to the ovary simulating primary mucinous cystadenocarcinoma of the ovary: report of a case. Virchows Arch 426:529–532PubMedCrossRefGoogle Scholar
  160. 160.
    Young RH (2004) Pseudomyxoma peritonei and selected other aspects of the spread of appendiceal neoplasms. Semin Diagn Pathol 21:134–150PubMedCrossRefGoogle Scholar
  161. 161.
    Young RH (2006) From Krukenberg to today: The ever present problems posed by metastatic tumors in the ovary. Part I. Historical perspective, general principles, mucinous tumors including the Krukenberg tumor. Adv Anat Pathol 13:205–227PubMedCrossRefGoogle Scholar
  162. 162.
    Young RH (2007) From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II. Adv Anat Pathol 14:149–177PubMedCrossRefGoogle Scholar
  163. 163.
    Young RH, Carey RW, Robboy SJ (1981) Breast carcinoma masquerading as a primary ovarian neoplasm. Cancer (Phila) 48:210–212CrossRefGoogle Scholar
  164. 164.
    Young RH, Eichhorn JH, Dickersin GR, Scully RE (1992) Ovarian involvement by the intra-abdominal desmoplastic small round cell tumor with divergent differentiation. A report of three cases. Hum Pathol 23:454–464PubMedCrossRefGoogle Scholar
  165. 165.
    Young RH, Gersell DJ, Clement PB, Scully RE (1992) Hepatocellular carcinoma metastatic to the ovary: a report of three cases discovered during life with discussion of the differential diagnosis of hepatoid tumors of the ovary. Hum Pathol 23:574–580PubMedCrossRefGoogle Scholar
  166. 166.
    Young RH, Gersell DJ, Roth LM, Scully RE (1993) Ovarian metastases from cervical carcinomas other than pure adenocarcinomas: a report of 12 cases. Cancer (Phila) 71:407–418CrossRefGoogle Scholar
  167. 167.
    Young RH, Gilks CB, Scully RE (1991) Mucinous tumors of the appendix associated with mucinous tumors of the ovary and pseudomyxoma peritonei: a clinicopathological analysis of 22 cases supporting an origin in the appendix. Am J Surg Pathol 15:415–429PubMedCrossRefGoogle Scholar
  168. 168.
    Young RH, Hart WR (1989) Metastases from carcinomas of the pancreas simulating primary mucinous tumors of the ovary: a report of seven cases. Am J Surg Pathol 13:748–756PubMedCrossRefGoogle Scholar
  169. 169.
    Young RH, Hart WR (1992) Renal cell carcinoma metastatic to the ovary: a report of three cases emphasizing possible confusion with ovarian clear cell adenocarcinoma. Int J Gynecol Pathol 11:96–104PubMedCrossRefGoogle Scholar
  170. 170.
    Young RH, Hart WR (1998) Metastatic intestinal carcinomas simulating primary ovarian clear cell carcinoma and secretory endometrioid carcinoma. A clinicopathologic and immunohistochemical study of five cases. Am J Surg Pathol 22:805–815PubMedCrossRefGoogle Scholar
  171. 171.
    Young RH, Jackson A, Wells M (1994) Ovarian metastasis from thyroid carcinoma twelve years after partial thyroidectomy mimicking struma ovarii. Report of a case. Int J Gynecol Pathol 13:181–185PubMedCrossRefGoogle Scholar
  172. 172.
    Young RH, Kozakewich HPW, Scully RE (1993) Metastatic ovarian tumors in children: a report of 14 cases and review of the literature. Int J Gynecol Pathol 12:8–19PubMedCrossRefGoogle Scholar
  173. 173.
    Young RH, Prat J, Scully RE (1984) Endometrial stromal sarcomas of the ovary. A clinicopathologic analysis of 23 cases. Cancer (Phila) 53:1143–1155CrossRefGoogle Scholar
  174. 174.
    Young RH, Scully RE (1985) Ovarian metastases from cancer of the lung: problems in interpretation – a report of seven cases. Gynecol Oncol 21:337–350PubMedCrossRefGoogle Scholar
  175. 175.
    Young RH, Scully RE (1988) Mucinous tumors of the ovary associated with mucinous adenocarcinomas of the cervix. A clinicopathological analysis of 16 cases. Int J Gynecol Pathol 7:99–111PubMedCrossRefGoogle Scholar
  176. 176.
    Young RH, Scully RE (1988) Urothelial and ovarian carcinomas of identical cell types: problems in interpretation. A report of three cases and review of the literature. Int J Gynecol Pathol 7:197–211PubMedCrossRefGoogle Scholar
  177. 177.
    Young RH, Scully RE (1989) Alveolar rhabdomyosarcoma metastatic to the ovary. A report of two cases and discussion of the differential diagnosis of small cell malignant tumors of the ovary. Cancer (Phila) 64:899–904CrossRefGoogle Scholar
  178. 178.
    Young RH, Scully RE (1990) Ovarian metastases from carcinoma of the gallbladder and extrahepatic bile ducts simulating primary tumors of the ovary: a report of six cases. Int J Gynecol Pathol 9:60–72PubMedCrossRefGoogle Scholar
  179. 179.
    Young RH, Scully RE (1990) Sarcomas metastatic to the ovary. A report of 21 cases. Int J Gynecol Pathol 9:231–252PubMedCrossRefGoogle Scholar
  180. 180.
    Young RH, Scully RE (1991) Malignant melanoma metastatic to the ovary: a clinicopathologic analysis of 20 cases. Am J Surg Pathol 15:849–860PubMedCrossRefGoogle Scholar
  181. 181.
    Young RH, Scully RE (1991) Metastatic tumors in the ovary: a problem-oriented approach and review of the recent literature. Semin Diagn Pathol 8:250–276PubMedGoogle Scholar
  182. 182.
    Young RH, Scully RE (2001) Differential diagnosis of ovarian tumors based primarily on their patterns and cell types. Semin Diagn Pathol 18:161–235PubMedGoogle Scholar
  183. 183.
    Yu TJ, Iwasaki I, Horie H, Tamaru J, Takahashi A (1986) Endolymphatic stromal myosis of the uterus with metastasis to ovary and recurrence in vagina. Acta Pathol Jpn 36:301–308PubMedGoogle Scholar
  184. 184.
    Zaino RJ, Unger ER, Whitney C (1984) Synchronous carcinomas of the uterine corpus and ovary. Gynecol Oncol 19:329–335PubMedCrossRefGoogle Scholar
  185. 185.
    Zaloudek C, Miller TR, Stern JL (1995) Desmoplastic small cell tumor of the ovary: a unique polyphenotypic tumor with an unfavorable prognosis. Int J Gynecol Oncol 14:260–265Google Scholar
  186. 186.
    Zamecnik M, Voltr L, Stuk J, Chlumska A (2008) Krukenberg tumor with yolk sac tumor differentiation. Int J Gynecol Pathol 27:223–228PubMedGoogle Scholar
  187. 187.
    Zhang PJ, Gao HG, Pasha TL, Litzky L, LiVolsi V (2009) TTF-1 expression in ovarian and uterine epithelial neoplasia and its potential significance, an immunohistochemical assessment with multiple monoclonal antibodies and different secondary detection systems. Int J Gynecol Pathol 28:10–18PubMedCrossRefGoogle Scholar
  188. 188.
    Zukerberg LR, Young RH (1990) Chordoma metastatic to the ovary: report of a case. Arch Path Lab Med 114:208–210PubMedGoogle Scholar

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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of PathologyMassachusetts General Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Anatomic PathologyJames Homer Wright Pathology Laboratories, Massachusetts General Hospital, Harvard Medical SchoolBostonUSA

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