Encyclopedia of Signaling Molecules

2012 Edition
| Editors: Sangdun Choi

DARPP

  • Daniela V. Rosa
  • Luiz Alexandre V. Magno
  • Bruno R. Souza
  • Marco A. Romano-Silva
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-0461-4_557

Synonyms

Historical Background

Recent studies using behavioral analysis of animal models suggest that alterations in critical intracellular signaling pathways have an important role in the pathophysiology and treatment of complex neuropsychiatric disorders. The hypothesis is that, if the vast majority of psychiatric medications exert their primary therapeutic actions in the first week of treatment, the therapeutic effects involve transcriptional changes initiated and maintained by critical intracellular signaling pathways.

The dopaminergic neurotransmission system has been the focus of much research throughout the last few decades, including psychiatric and neurological...

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References

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Daniela V. Rosa
    • 1
  • Luiz Alexandre V. Magno
    • 1
  • Bruno R. Souza
    • 2
  • Marco A. Romano-Silva
    • 3
  1. 1.INCT de Medicina MolecularUniversidade Federal de Minas GeraisBelo HorizonteBrazil
  2. 2.Department of Cell & Systems Biology, Centre for the Analysis of Genome Evolution and FunctionUniversity of TorontoTorontoCanada
  3. 3.INCT de Medicina Molecular; Departamento de Saúde MentalUniversidade Federal de Minas GeraisBelo HorizonteBrazil