Historical Background
Cyclic 3’5’ adenosine monophosphate (cAMP) is a key second messenger that is responsible for regulating many pivotal signaling processes in all mammalian cell types (Tasken and Aandahl 2004). It influences cell growth, differentiation, shape, and movement as well as processes such a cardiac contraction, metabolism, water retention, learning, and memory. Most intriguingly, however, cAMP can selectively regulate a variety of very different processes in any one particular cell type. Indeed, uncovering the molecular mechanisms that allow cAMP to selectively regulate disparate processes within a single cell has provided a major challenge. Only very recently has the means whereby cAMP signaling is compartmentalized in cells begun to be understood (Tasken and Aandahl 2004; Baillie et al. 2005; Willoughby and Cooper 2007). One key requirement is for spatially discrete signaling complexes to be assembled in...
References
Baillie GS, Scott JD, Houslay MD. Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract. FEBS Lett. 2005;579:3264–70.
Conti M, Beavo J. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Annu Rev Biochem. 2007;76:481–511.
Houslay MD. Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown. Trends Biochem Sci. 2010;35:91–100.
Houslay MD, Adams DR. PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization. Biochem J. 2003;370:1–18.
Houslay MD, Adams DR. Putting the lid on phosphodiesterase 4. Nat Biotechnol. 2010;28:38–40.
Houslay MD, Schafer P, Zhang KY. Keynote review: phosphodiesterase-4 as a therapeutic target. Drug Discov Today. 2005;10:1503–19.
Keravis T, Lugnier C. Cyclic nucleotide phosphodiesterases (PDE) and peptide motifs. Curr Pharm Des. 2010;16:1114–25.
Lugnier C. Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents. Pharmacol Ther. 2006;109:366–98.
Murdoch H, Vadrevu S, Prinz A, Dunlop A, Klussmann E, Bolger GB, Norman JC, Houslay MD. LIS1/cAMP phosphodiesterase-4 (PDE4) interaction and their role in cytoplasmic dynein function. J Cell Sci. 2011;124:2253–66.
Tasken K, Aandahl ME. Localized effects of cAMP mediated by distinct routes of protein kinase A. Physiol Rev. 2004;84:137–67.
Willoughby D, Cooper DM. Organization and Ca2+ regulation of adenylyl cyclases in cAMP microdomains. Physiol Rev. 2007;87:965–1010.
Zaccolo M. cAMP signal transduction in the heart: understanding spatial control for the development of novel therapeutic strategies. Br J Pharmacol. 2009;158:50–60.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer Science+Business Media, LLC
About this entry
Cite this entry
Houslay, M.D. (2012). PDE4. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0461-4_336
Download citation
DOI: https://doi.org/10.1007/978-1-4419-0461-4_336
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4419-0460-7
Online ISBN: 978-1-4419-0461-4
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences