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Encyclopedia of Signaling Molecules pp 1483–1488Cite as

Protein Tyrosine Kinase-6 (PTK6)

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Synonyms

Breast Tumor Kinase (Brk)

Historical Background

The intracellular protein tyrosine kinase, PTK6 (also known as the breast tumor kinase, Brk), has been implicated in the development and progression of a number of different tumor types. First identified in three separate studies in the early 1990s, it was initially found in a study to determine which tyrosine kinases were expressed in human melanocytes and then the full-length sequence was subsequently cloned from metastatic breast cancer using a screen to identify novel kinases that were expressed in tumors, but not normal breast tissue. Identification of the murine orthologue, Sik, in mouse intestinal cells was achieved by the generation of a library of kinase catalytic domains.

PTK6 is related to the Src family of protein kinases and belongs to a distinct class of enzymes which includes Frk and SRMS (reviewed in Brauer and Tyner 2010). Under normal physiological conditions, PTK6 expression is highly controlled and is usually...

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References

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Author information

Authors and Affiliations

  1. Brunel Institute for Cancer Genetics and Pharmacogenomics, Brunel University, West London, UK

    Amanda Harvey

Authors
  1. Amanda Harvey
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Corresponding author

Correspondence to Amanda Harvey .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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© 2012 Springer Science+Business Media, LLC

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Harvey, A. (2012). Protein Tyrosine Kinase-6 (PTK6). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0461-4_305

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