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p38 MAPK Family of Signal Transduction Proteins

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Encyclopedia of Signaling Molecules

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References

  • Ben-Levy R, Hooper S, Wilson R, Paterson HF, Marshall CJ. Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2. Curr Biol. 1998;8:1049–57.

    PubMed  CAS  Google Scholar 

  • Cardier JE, Erickson-Miller CL. Fas (CD95)-and tumor necrosis factor mediated apoptosis in liver endothelial cells; role of caspase-3 and the p38 MAPK. Microvasc Res. 2002;63:10–8.

    PubMed  CAS  Google Scholar 

  • Conrad PW, Rust RT, Han J, Milkorn DE, Beitner-Johnson D. Selective activation of p38α and p38β by anoxia. Role in regulation of cyclin D1 by hypoxia in PC12 cells. J Biol Chem. 1999;274:23570–6.

    PubMed  CAS  Google Scholar 

  • Cuadrado A, Nebreda AR. Mechanism and functions of p38 MAPK signaling. Biochem J. 2010;429:403–17.

    PubMed  CAS  Google Scholar 

  • Engel K, Schultz H, Martin F, Kotlyarov A, Plath K, Hahn M, et al. Constitutive activation of mitogen-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif. J Biol Chem. 1995;270:27213–21.

    PubMed  CAS  Google Scholar 

  • Enslen H, Raingeaud J, Davis RJ. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. J Biol Chem. 1998;273:1741–8.

    PubMed  CAS  Google Scholar 

  • Gavin AC, Nebreda AR. A MAP kinase docking site is required for phosphorylation and activation of p90(rsk)/MAPKP kinase-1. Curr Biol. 1999;11:281–4.

    Google Scholar 

  • Haq R, Brenton JD, Takahashi M, Finan D, Finkelsztein A, Damaraju S, Rotapel R, Zanke B. Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence. Cancer Res. 2002;62:5076–82.

    PubMed  CAS  Google Scholar 

  • Hutter D, Chen P, Barnes J, Liu Y. Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulation. Biochemistry. 2000;352:155–63.

    CAS  Google Scholar 

  • Jiang Y, Gram H, Zhao M, New L, Gu J, Feng L, Padova F, Ulevitch R, Han J. Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38δ. J Biol Chem. 1997;333:30122–8.

    Google Scholar 

  • Keyse SM. Protein phosphatases and the regulation of mitogen-activated protein kinase signaling. Curr Opin Cell Biol. 2000;12:186–92.

    PubMed  CAS  Google Scholar 

  • Kim DH, Feinbaum R, Alloing G, Emerson FE, Garsin DA, Inoue H, Tanaka-Hino M, Hisamoto N, Matsumoto K, Tan V-W, Ausubel FM. A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Science. 2002;297:623–6.

    PubMed  CAS  Google Scholar 

  • Lechner C, Zahalka MA, Giot F-F, Moler NPH, Ullrich A. ERK6, a mitogen-activated protein kinase involved in G2C12 myoblast differentiation. Proc Natl Acad Sci USA. 1996;93:4355–9.

    PubMed  CAS  Google Scholar 

  • Lee JC, Kassis S, Kumar S, Badger A, Adams JL. p38-mitogen activated protein kinase inhibitors—mechanisms and therapeutic potentials. Pharmacol Ther. 1999;82:389–97.

    PubMed  CAS  Google Scholar 

  • Li Z, Jiang Y, Ulevitch RJ, Han J. The primary structure of p38gamma: a new member of p38 group of MAP kinases. Biochem Biophys Res Commun. 1996;228:334–40.

    PubMed  CAS  Google Scholar 

  • Muda M, Theodosiou A, Gillieron C, Smith A, Chabert C, Camps M, Boschert U, Rodrigues N, Davies K, Ashworth A, Arkinstall S. The mitogen-activated protein kinase phosphatase-3 N-terminal noncatalytic region is responsible for tight substrate binding and enzymatic specificity. J Biol Chem. 1998;273:9323–9.

    PubMed  CAS  Google Scholar 

  • Ono K, Han J. The p38 signal pathway activation and function. Cell Signal. 2000;12:1–13.

    PubMed  CAS  Google Scholar 

  • Papaconstantinou J, Hsieh C-C. Activation of senescence and aging characteristics by mitochondrially generated Ros: how are they linked? Cell Cycle. 2010;9:1–3.

    Google Scholar 

  • Park JM, Greten FR, Li ZW, Karin M. Macrophage apoptosis by anthrax lethal factor through p38 MAP kinase inhibition. Science. 2002;297:2048–51.

    PubMed  CAS  Google Scholar 

  • Peifer C, Abadleh M, Bischof J, Hauser D, Schattel V, Hirner H, Knippschild U, Laufer S. 3,4-diaryl-isoxazoles and –imidazoles as potent dual inhibitors of p38α mitogen activated protein kinase and casein kinase 1δ. J Med Chem. 2009;52:7618–730.

    PubMed  CAS  Google Scholar 

  • Saurin AT, Martin JL, Heads RJ, Foley C, Mockridge JW, Wright MJ, Wang Y, Marber MS. The role of differential activation of p38-mitogen-activated protein kinase in preconditioned ventricular myocytes. FASEB J. 2000;14:2237–46.

    PubMed  CAS  Google Scholar 

  • Suh Y. Age-specific changes in expression, activity, and activation of the c-Jun NH(2)-terminal kinase and p38 mitogen-activated protein kinases by methyl methanesulfonate in rats. Mech Age Dev. 2001;122:1797–811.

    CAS  Google Scholar 

  • Tanoue T, Ryota M, Adachi M, Nichida E. Identification of docking groove on ERK and p38 MAP kinases that regulate the specificity of docking interactions. EMBO J. 2001;20:466–79.

    PubMed  CAS  Google Scholar 

  • Wang YU, Huang S, Sah VP, Ross Jr J, Brown JH, Han J, Chien KR. Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. J Biol Chem. 1998;273:2161–8.

    PubMed  CAS  Google Scholar 

  • Yang SH, Whitemarsh AJ, Davis RJ, Sharrocks AD. Differential targeting of MAP kinases to the ETS-domain transcription factor E1k-1. EMBO J. 1998;17:1740–9.

    PubMed  CAS  Google Scholar 

  • Yang SH, Galanis A, Sharrocks AD. 1999 Targeting of p38 mitogen-activated protein kinase to MEF2 transcription factors. Mol Cell Biol. 1999;19:4028–38.

    PubMed  CAS  Google Scholar 

  • Zer C, Sachs G, Shin JM. Identification of genomic targets downstream of p38 mitogen-activated protein kinase pathway mediating tumor necrosis factor-α signaling. Physiol Genomics. 2007;31:343–51.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555-0643, USA

    Prof. John Papaconstantinou, Ching-Chyuan Hsieh & James H. DeFord

  2. Department of Human Biological Chemistry and Genetics, The University of Texas Medical Branch, Galveston, TX, 77555-0643, USA

    Prof. John Papaconstantinou

Authors
  1. Prof. John Papaconstantinou
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  2. Ching-Chyuan Hsieh
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  3. James H. DeFord
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Corresponding author

Correspondence to John Papaconstantinou .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Papaconstantinou, J., Hsieh, CC., DeFord, J.H. (2012). p38 MAPK Family of Signal Transduction Proteins. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0461-4_221

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