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Pea15

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Encyclopedia of Signaling Molecules

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References

  • Araujo H, Danziger N, Cordier J, Glowinski J, Chneiweiss H. Characterization of PEA-15, a major substrate for protein kinase C in astrocytes. J Biol Chem. 1993;268(8):5911–20.

    PubMed  CAS  Google Scholar 

  • Bartholomeusz C, Itamochi H, Nitta M, Saya H, Ginsberg MH, Ueno NT. Antitumor effect of E1A in ovarian cancer by cytoplasmic sequestration of activated ERK by PEA15. Oncogene. 2006;25(1):79–90.

    PubMed  CAS  Google Scholar 

  • Bartholomeusz C, Gonzalez-Angulo AM, Kazansky A, Krishnamurthy S, Liu P, Yuan LX, et al. PEA-15 inhibits tumorigenesis in an MDA-MB-468 triple-negative breast cancer xenograft model through increased cytoplasmic localization of activated extracellular signal-regulated kinase. Clin Cancer Res. 2010;16(6):1802–11.

    PubMed  CAS  Google Scholar 

  • Bera TK, Guzman RC, Miyamoto S, Panda DK, Sasaki M, Hanyu K, et al. Identification of a mammary transforming gene (MAT1) associated with mouse mammary carcinogenesis. ProcNatlAcadSciUSA. 1994;91(21):9789–93.

    CAS  Google Scholar 

  • Condorelli G, Vigliotta G, Iavarone C, Caruso M, Tocchetti CG, Andreozzi F, et al. PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus. EMBO J. 1998;17(14):3858–66.

    PubMed  CAS  Google Scholar 

  • Condorelli G, Vigliotta G, Cafieri A, Trencia A, Andalo P, Oriente F, et al. PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis. Oncogene. 1999;18(31):4409–15.

    PubMed  CAS  Google Scholar 

  • Estelles A, Yokoyama M, Nothias F, Vincent JD, Glowinski J, Vernier P, et al. The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs conserved on their full length in mouse and human. J Biol Chem. 1996;271(25):14800–6.

    PubMed  CAS  Google Scholar 

  • Fiory F, Formisano P, Perruolo G, Beguinot F. Frontiers: PED/PEA-15, a multifunctional protein controlling cell survival and glucose metabolism. Am J Physiol Endocrinol Metab. 2009;297(3):E592–601.

    PubMed  CAS  Google Scholar 

  • Formstecher E, Ramos JW, Fauquet M, Calderwood DA, Hsieh JC, Canton B, et al. PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase. Dev Cell. 2001;1(2):239–50.

    PubMed  CAS  Google Scholar 

  • Glading A, Koziol JA, Krueger J, Ginsberg MH. PEA-15 inhibits tumor cell invasion by binding to extracellular signal-regulated kinase 1/2. Cancer Res. 2007;67(4):1536–44.

    PubMed  CAS  Google Scholar 

  • Kitsberg D, Formstecher E, Fauquet M, Kubes M, Cordier J, Canton B, et al. Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis. J Neurosci. 1999;19(19):8244–51.

    PubMed  CAS  Google Scholar 

  • Pastorino S, Renganathan H, Caliva MJ, Filbert EL, Opoku-Ansah J, Sulzmaier FJ, et al. The death effector domain protein PEA-15 negatively regulates T-cell receptor signaling. FASEB J. 2010;24(8):2818–28.

    Google Scholar 

  • Ramos JW. Cancer research center hotline: PEA-15 phosphoprotein: a potential cancer drug target. Hawaii MedJ. 2005;64(3):77–80.

    Google Scholar 

  • Ramos JW. The regulation of extracellular signal-regulated kinase (ERK) in mammalian cells. Int J Biochem Cell Biol. 2008;40(12):2707–19.

    PubMed  CAS  Google Scholar 

  • Ramos JW, Kojima TK, Hughes PE, Fenczik CA, Ginsberg MH. The death effector domain of PEA-15 is involved in its regulation of integrin activation. J Biol Chem. 1998;273(51):33897–900.

    PubMed  CAS  Google Scholar 

  • Ramos JW, Townsend DA, Piarulli D, Kolata S, Light K, Hale G, et al. Deletion of PEA-15 in mice is associated with specific impairments of spatial learning abilities. BMC Neurosci. 2009;10:134.

    PubMed  Google Scholar 

  • Renault-Mihara F, Beuvon F, Iturrioz X, Canton B, De BS, Leonard N, et al. Phosphoprotein enriched in astrocytes-15 kDa expression inhibits astrocyte migration by a protein kinase C delta-dependent mechanism. Mol Biol Cell. 2006;17(12):5141–52.

    PubMed  CAS  Google Scholar 

  • Vaidyanathan H, Opoku-Ansah J, Pastorino S, Renganathan H, Matter ML, Ramos JW. ERK MAP kinase is targeted to RSK2 by the phosphoprotein PEA-15. Proc Natl Acad Sci USA. 2007;104(50):19837–42.

    PubMed  CAS  Google Scholar 

  • Valmiki MG, Ramos JW. Death effector domain-containing proteins. Cell Mol Life Sci. 2009;66(5):814–30.

    PubMed  CAS  Google Scholar 

  • Watanabe Y, Yamasaki F, Kajiwara Y, Saito T, Nishimoto T, Bartholomeusz C, et al. Expression of phosphoprotein enriched in astrocytes 15 kDa (PEA-15) in astrocytic tumors: a novel approach of correlating malignancy grade and prognosis. J Neurooncol. 2010;100(3):449–457.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. University of Hawai’i Cancer Center, University of Hawai’i at Manoa, 651 Ilalo Street, Honolulu, HI, 96813, USA

    Dr. Joanna E. Gawecka

  2. The Cancer Research Center of Hawaii, University of Hawaii, 651 Ilalo Street, Honolulu, HI, 96813, USA

    Dr. Joe W. Ramos

Authors
  1. Dr. Joanna E. Gawecka
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  2. Dr. Joe W. Ramos
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Corresponding author

Correspondence to Joanna E. Gawecka .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Gawecka, J.E., Ramos, J.W. (2012). Pea15. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0461-4_212

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