Phosphoprotein Enriched in Astrocytes 15 kDa (PEA-15), also known as PED-15, is a 15 kDa protein that is highly expressed in the nervous system with particularly high levels in astrocytes and neurons of the hippocampus. Chneiweiss and colleagues first characterized PEA-15 as a major substrate for Protein Kinase C (PKC) in astrocytes and later cloned the cDNA encoding the protein (Araujo et al. 1993; Estelles et al. 1996). Subsequently, a portion of the 3′ UTR of the PEA-15 mRNA, called MAT1, was identified as a mammary transforming gene associated with mouse mammary carcinogenesis (Bera et al. 1994). It remains unclear how this relates to the function of the full-length PEA-15 protein. The initial functional significance of PEA-15 was identified when it was shown to be a phosphoprotein...
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