ASK (activator of S phase kinase)/huDbf4 (human); Chiffon (Drosophila); Dbf4 (dumbbell former 4)/DNA52 (Saccharomyces cerevisiae); Dbf4l1; Dfp1/Him1/Rad35 (Schizosaccharomyces pombe), Spo6 (a second Dbf4 homologue in S. pombe); Drf1/ASKL1 (a second activator of Cdc7 in human and Xenopus); nimO (Aspergillus)
dbf4 (dumbbell former 4) mutation was originally identified in the screening for budding yeast temperature-sensitive mutants which arrest with dumbbell-shaped phenotype at the nonpermissive temperature (Johnston and Thomas 1982). The terminal phenotypes of dbf4(ts) strain at a nonpermissive temperature were very similar to those of cdc7(ts), encoding a serine-threonine kinase known to be essential for initiation of DNA replication. Later, dbf4 was rediscovered as a multi-copy suppressor of cdc7(ts), suggesting physical and functional interactions between Cdc7 and Dbf4 (Kitada et al. 1992). Following this finding, Dbf4 was shown to bind to Cdc7...
- James SW, Bullock KA, Gygax SE, Kraynack BA, Matura RA, MacLeod JA, McNeal KK, Prasauckas KA, Scacheri PC, Shenefiel HL, Tobin HM, Wade SD. nimO, an Aspergillus gene related to budding yeast Dbf4, is required for DNA synthesis and mitotic checkpoint control. J Cell Sci. 1999;112(Pt 9):1313–24.PubMedGoogle Scholar
- Kitamura R, Fukatsu R, Kakusho N, Cho Y-S, Taniyama C, Yamazaki S, Toh G-T, Yanagi K, Arai N, Chang, H-J, Masai H. Molecular mechanism of activation of human Cdc7 kinase: Bipartite interaction with Dbf4/ASK stimulates ATP binding and substrate recognition. J Biol Chem. 2011;286:23031–43.PubMedCrossRefGoogle Scholar
- Takeda T, Ogino K, Matsui E, Cho MK, Kumagai H, Miyake T, Arai K, Masai H. A fission yeast gene, him1(+)/dfp1(+), encoding a regulatory subunit for Hsk1 kinase, plays essential roles in S-phase initiation as well as in S-phase checkpoint control and recovery from DNA damage. Mol Cell Biol. 1999;19(8):5535–47.PubMedGoogle Scholar
- Yamada M, Sato N, Taniyama C, Ohtani K, Arai K, Masai H. A 63-base pair DNA segment containing an Sp1 site but not a canonical E2F site can confer growth-dependent and E2F-mediated transcriptional stimulation of the human ASK gene encoding the regulatory subunit for human Cdc7-related kinase. J Biol Chem. 2002;277(31):27668–81.PubMedCrossRefGoogle Scholar