Encyclopedia of Signaling Molecules

2012 Edition
| Editors: Sangdun Choi


  • Hisao Masai
Reference work entry
DOI: https://doi.org/10.1007/978-1-4419-0461-4_186


Historical Background

dbf4 (dumbbell former 4) mutation was originally identified in the screening for budding yeast temperature-sensitive mutants which arrest with dumbbell-shaped phenotype at the nonpermissive temperature (Johnston and Thomas 1982). The terminal phenotypes of dbf4(ts) strain at a nonpermissive temperature were very similar to those of  cdc7(ts), encoding a serine-threonine kinase known to be essential for initiation of DNA replication. Later, dbf4 was rediscovered as a multi-copy suppressor of  cdc7(ts), suggesting physical and functional interactions between  Cdc7 and Dbf4 (Kitada et al. 1992). Following this finding, Dbf4 was shown to bind to  Cdc7...

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Genome Dynamics Project, Department of Genome MedicineTokyo Metropolitan Institute of Medical ScienceTokyoJapan